CAREER: Biochemical Reaction Mechanisms by Real-Time, Hyperpolarization Enhanced Nuclear Magnetic Resonance

职业:通过实时超极化增强核磁共振研究生化反应机制

基本信息

  • 批准号:
    0846402
  • 负责人:
  • 金额:
    $ 55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-02-01 至 2015-01-31
  • 项目状态:
    已结题

项目摘要

In this award, Dr. Hilty from Texas A&M University will utilize the recently developed, commercially available Hypersense polarizer to create enhanced nuclear spin polarization through dynamic nuclear polarization from contact with organic radicals. Integration of stopped-flow methods will allow him to study dynamics in enzymatic processes and protein folding. Dr. Hilty's educational plan involves development of new demonstrations for the physical chemistry lecture course, and his participation in the "Chemistry Road Show" to reach out to high school students in rural areas of Texas. Dr. Hilty plans to develop science kits that can be delivered to the schools via postal service if neither he nor his students can pay a personal visit. The study of dynamic processes, that is, processes captured on the same time scale as they occur, is a challenging problem in chemistry when performed with molecular level resolution. Nuclear magnetic resonance (NMR) spectroscopy, the sister technique to magnetic resonance imaging (MRI), is a powerful and wide-spread tool in chemistry to investigate molecular structure. Unfortunately, it does not lend itself very well to the study of dynamic processes, as these often involve intermediate species in small concentrations that NMR is not sufficiently sensitive to detect. So-called dynamic nuclear polarization (DNP) is a clever technique that was devised in the 1950's to make NMR more sensitive - its downside is that it must be performed at very low temperatures, that is -456 F! At these temperatures, all molecules are frozen and dynamic processes come to a standstill. Since the DNP advantage disappears in a matter of seconds, the samples must be warmed up very rapidly so that dynamics can be studied. Dr. Hilty from Texas A&M University has developed an apparatus that allows him to do exactly that - with it, he plans to investigate enzymatic reactions and the folding of proteins. These processes occur in our bodies every single day, and their dysfunction is responsible for many diseases such as Alzheimer's. College students must enroll in physical chemistry courses to be able to understand and do research such as Dr. Hilty's. The material is challenging with a strong mathematical component that makes it hard for students to establish connections with real-world phenomena. Dr. Hilty will improve the physical chemistry curriculum by developing demonstrations to be shared with other instructors to help students see these connections, ultimately resulting in better student learning and enthusiasm for the field. In order to engage students in this fascinating field earlier in their career, he partners with Texas A & M's "Chemistry Road Show" that is taken to high schools in rural areas of TX. Dr. Hilty will enrich the show that is currently based on chemistry demonstrations by developing hands-on activities.
在这个奖项中,来自德克萨斯A M大学的Hilty博士将利用最近开发的商用Hypersense偏振器,通过与有机自由基接触的动态核极化来创建增强的核自旋极化。停止流动方法的整合将使他能够研究酶促过程和蛋白质折叠的动力学。Hilty博士的教育计划包括为物理化学讲座课程开发新的演示,以及他参加“化学路演”,以接触德克萨斯州农村地区的高中生。Hilty博士计划开发科学工具包,如果他和他的学生都不能亲自访问,可以通过邮政服务送到学校。动态过程的研究,也就是说,在相同的时间尺度上捕获的过程,因为它们发生,是一个具有挑战性的问题,在化学与分子水平的分辨率进行。核磁共振(NMR)光谱是磁共振成像(MRI)的姊妹技术,是化学中研究分子结构的强大而广泛的工具。不幸的是,它并不适合自己很好的动态过程的研究,因为这些往往涉及在小浓度的中间物种,核磁共振是不够敏感的检测。所谓的动态核极化(DNP)是一种聪明的技术,是在20世纪50年代设计的,以使NMR更灵敏-其缺点是它必须在非常低的温度下进行,即-456 F!在这样的温度下,所有分子都被冻结,动态过程停止。由于DNP优势在几秒钟内消失,样品必须非常迅速地升温,以便研究动态。来自德克萨斯A M大学的Hilty博士开发了一种仪器,使他能够做到这一点-他计划用它来研究酶反应和蛋白质的折叠。这些过程每天都发生在我们的身体中,它们的功能障碍是导致许多疾病的原因,如阿尔茨海默氏症。大学生必须参加物理化学课程,才能理解和做像希尔蒂博士这样的研究。该材料具有很强的数学成分,使学生很难与现实世界的现象建立联系。Hilty博士将通过开发演示来改进物理化学课程,与其他教师分享,以帮助学生看到这些联系,最终使学生更好地学习和对该领域的热情。为了让学生在职业生涯的早期就参与到这个迷人的领域中,他与德克萨斯A M的“化学路演”合作,该路演被带到德克萨斯州农村地区的高中。Hilty博士将通过开发实践活动来丰富目前基于化学演示的节目。

项目成果

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Christian Hilty其他文献

Calculations of neon nuclear-spin optical rotation, Verdet and hyperfine constants with configuration-interaction many-body perturbation theory
  • DOI:
    10.1140/epjd/e2019-90431-7
  • 发表时间:
    2019-07-25
  • 期刊:
  • 影响因子:
    1.500
  • 作者:
    Igor Savukov;Dmytro Filin;Yue Zhu;Rafael Castro;Christian Hilty
  • 通讯作者:
    Christian Hilty
Large Faraday rotation in pyrolysis synthesized carbon dots
  • DOI:
    10.1016/j.carbon.2024.119895
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Zefan Zhang;Igor Savukov;Christian Hilty
  • 通讯作者:
    Christian Hilty
Controlling membrane permeability with bacterial porins: application to encapsulated enzymes.
用细菌孔蛋白控制膜通透性:应用于封装酶。

Christian Hilty的其他文献

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{{ truncateString('Christian Hilty', 18)}}的其他基金

Collaborative Research: Nuclear Spin Optical Rotation of Hyperpolarized Liquids and Solids
合作研究:超极化液体和固体的核自旋旋光
  • 批准号:
    2108822
  • 财政年份:
    2021
  • 资助金额:
    $ 55万
  • 项目类别:
    Standard Grant
Characterization of Macromolecular Dynamics Using Para-hydrogen Induced Polarization of Nuclear Spins
利用仲氢诱导核自旋极化表征大分子动力学
  • 批准号:
    1900406
  • 财政年份:
    2019
  • 资助金额:
    $ 55万
  • 项目类别:
    Standard Grant
Characterization of Solvent-Macromolecule Interactions using Dissolution Dynamic Nuclear Polarization
使用溶解动态核极化表征溶剂-大分子相互作用
  • 批准号:
    1362691
  • 财政年份:
    2014
  • 资助金额:
    $ 55万
  • 项目类别:
    Standard Grant
Collaborative Research: DNP-Enhanced Nuclear-Spin Optical-Rotation Spectroscopy
合作研究:DNP 增强核自旋旋光光谱
  • 批准号:
    1404548
  • 财政年份:
    2014
  • 资助金额:
    $ 55万
  • 项目类别:
    Standard Grant

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