CAREER: Molecular Motors and Protein Motion: From Mechanisms to Collective Effects

职业：分子马达和蛋白质运动：从机制到集体效应

• 批准号: 0847685
• 负责人: Meredith Betterton
• 金额: $ 42.5万
• 依托单位: University of Colorado at Boulder
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847685&HistoricalAwards=false
• 关键词: CAREER; Molecular; Motors; Protein; Motion

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). TECHNICAL SUMMARYThis CAREER award will support an integrated research and education program in the field of theoretical biophysics, with interdisciplinary support from the Division of Materials Research, the Division of Molecular and Cellular Biosystems, and the Division of Mathematical Sciences. The research component will address addresses the theory of directed and diffusive protein motion, active gels, and DNA target recognition, with emphasis on incorporating polymer elasticity effects into models of protein motion on DNA and crowding and collective effects in protein motion.The research will have applications in important biological problems such as gene expression, DNA copying, DNA repair, and cell division. It will contribute to the broader effort in the community studying molecular motors to understand diverse motor proteins, and to develop theoretical tools to predict the behavior of systems of interacting proteins. It will also contribute to understanding both the function of motor proteins in crowded cellular environments, and the role of nucleic-acid motors in macromolecular complexes. This work is strongly interdisciplinary, because the research bridges statistical physics, theoretical chemistry, and molecular biophysics.The education component aims to increase the connection between physics and biology in introductory physics courses at CU-Boulder. Integrating biologically relevant course materials will help students understand that physics is important in many fields, including biology and medicine. The second education aim is to integrate biophysics into the undergraduate physics curriculum at CU-Boulder by developing a biophysics course. The physics department does not currently teach a biophysics course, so this aim will enhance the education of students at CU-Boulder. The proposed education work will be carried out in collaboration with the Physics Education Research group at the University of Colorado to incorporate cutting-edge educational methods and assessment.NONTECHNICAL SUMMARYThis CAREER award will support an integrated research and education program in the field of theoretical biophysics, with interdisciplinary support from the Division of Materials Research, the Division of Molecular and Cellular Biosystems, and the Division of Mathematical Sciences. The research component of this award addresses novel problems in theoretical biophysics involving the directed and random motions of proteins and related biomolecular systems. The research will have applications in important biological problems such as gene expression, DNA copying, DNA repair, and cell division. It will contribute to the broader effort in the community studying molecular motors to understand diverse motor proteins, and to develop theoretical tools to predict the behavior of systems of interacting proteins. It will also contribute to understanding both the function of motor proteins in crowded cellular environments, and the role of nucleic-acid motors in macromolecular complexes. This work is strongly interdisciplinary, because the research bridges statistical physics, theoretical chemistry, and molecular biophysics.The education component aims to increase the connection between physics and biology in introductory physics courses at CU-Boulder. Integrating biologically relevant course materials will help students understand that physics is important in many fields, including biology and medicine. The second education aim is to integrate biophysics into the undergraduate physics curriculum at CU-Boulder by developing a biophysics course. The physics department does not currently teach a biophysics course, so this aim will enhance the education of students at CU-Boulder. The proposed education work will be carried out in collaboration with the Physics Education Research group at the University of Colorado to incorporate cutting-edge educational methods and assessment.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。技术摘要该职业奖将支持理论生物物理学领域的综合研究和教育计划，并得到材料研究部、分子和细胞生物系统部以及数学科学部的跨学科支持。 研究内容包括蛋白质定向运动和扩散运动理论、活性凝胶和DNA靶点识别理论，重点是将聚合物弹性效应纳入蛋白质运动模型，以及蛋白质运动中的拥挤和聚集效应。研究将在基因表达、DNA复制、DNA修复和细胞分裂等重要生物学问题中得到应用。 它将有助于在社区研究分子马达更广泛的努力，以了解不同的马达蛋白，并开发理论工具来预测相互作用的蛋白质系统的行为。它也将有助于理解在拥挤的细胞环境中马达蛋白的功能，以及核酸马达在大分子复合物中的作用。 这项工作是强烈的跨学科，因为研究桥梁统计物理学，理论化学和分子生物物理学。教育部分的目的是增加物理学和生物学之间的联系，在CU-Boulder的入门物理课程。整合生物学相关的课程材料将帮助学生理解物理学在许多领域都很重要，包括生物学和医学。 第二个教育目标是通过开发生物物理课程将生物物理学融入CU-Boulder的本科物理课程。 物理系目前不教生物物理学课程，因此这一目标将加强CU-Boulder学生的教育。拟议的教育工作将与科罗拉多大学的物理教育研究小组合作进行，以纳入尖端的教育方法和评估。非技术性总结该职业奖将支持理论生物物理学领域的综合研究和教育计划，并得到材料研究部，分子和细胞生物系统部，和数学科学部 该奖项的研究部分解决了理论生物物理学中的新问题，涉及蛋白质和相关生物分子系统的定向和随机运动。 这项研究将在重要的生物学问题中得到应用，如基因表达，DNA复制，DNA修复和细胞分裂。 它将有助于在社区研究分子马达更广泛的努力，以了解不同的马达蛋白，并开发理论工具来预测相互作用的蛋白质系统的行为。它也将有助于理解在拥挤的细胞环境中马达蛋白的功能，以及核酸马达在大分子复合物中的作用。 这项工作是强烈的跨学科，因为研究桥梁统计物理学，理论化学和分子生物物理学。教育部分的目的是增加物理学和生物学之间的联系，在CU-Boulder的入门物理课程。 整合生物学相关的课程材料将帮助学生理解物理学在许多领域都很重要，包括生物学和医学。 第二个教育目标是通过开发生物物理课程将生物物理学融入CU-Boulder的本科物理课程。 物理系目前不教生物物理学课程，因此这一目标将加强CU-Boulder学生的教育。 拟议的教育工作将与科罗拉多大学的物理教育研究小组合作进行，以纳入尖端的教育方法和评估。