Molecular basis underlying type III effector evolution: discovering the recognition specificity of the diversified HopZ1 alleles in Pseudomonas syringae

III型效应子进化的分子基础:发现丁香假单胞菌中多样化的HopZ1等位基因的识别特异性

基本信息

  • 批准号:
    0847870
  • 负责人:
  • 金额:
    $ 52.96万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-07-01 至 2012-12-31
  • 项目状态:
    已结题

项目摘要

"This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)."Pathogens and hosts are engaged in an endless and deadly warfare. Type III secretion system (T3SS) and secreted effectors (T3SEs) are essential virulence factors of gram negative bacterial pathogens, some of which are responsible for the most devastating diseases of plants and animals. During the arms race with bacterial pathogens, plants have evolved resistance (R) genes to detect specific pathogen T3SEs and induce defense responses. However, this immunity can be efficiently defeated by the pathogen through effector sequence variation. This project seeks to offer important insights into the mechanisms underlying the highly dynamic co-evolutionary arms races between key virulence factors in pathogens and the corresponding host defense strategies. The research will focus on HopZ1, a widely distributed T3SE family of the model plant pathogen Pseudomonas syringae. While the ancestor-like HopZ1 allele triggers plant defense response, sequence diversification has allowed evolved alleles to evade host detection while retaining virulence functions. The investigators will employ genetic screens and biochemical analyses to compare the host protein interaction spectrums of HopZ1 allelic variants and identify important plant players involved in the arms race in an effort to understand sequence diversification-enabled effector evolution. Novel knowledge obtained from this research will contribute to the development of sustainable means to control bacterial diseases and improve food safety. This project will have broad impacts on education, outreach and scientific research. It will offer comprehensive training and educational activities for undergraduates, graduate and postdoctoral researchers, especially for underrepresented minority groups and first-generation college students. Novel knowledge generated from this project will be disseminated in a timely manner to the scientific community in the forms of journal articles, conference proceedings and website postings, and also to a broad audience through teaching activities of the investigator to undergraduate and graduate students.
“该奖项是根据2009年美国复苏和再投资法案(公法111-5)资助的。“病原体和宿主正在进行一场无休止的致命战争。III型分泌系统(T3 SS)和分泌型效应子(T3 SEs)是革兰氏阴性细菌病原体的重要毒力因子,其中一些是导致动植物最具毁灭性疾病的致病因子。 在与细菌病原体的军备竞赛中,植物已经进化出抗性(R)基因来检测特定的病原体T3 SE并诱导防御反应。 然而,这种免疫力可以通过效应子序列变异被病原体有效地击败。 该项目旨在为病原体中关键毒力因子与相应宿主防御策略之间高度动态的协同进化军备竞赛机制提供重要见解。 这项研究将集中在HopZ 1,一个广泛分布的T3 SE家族的模式植物病原体假单胞菌。 虽然祖先一样的HopZ 1等位基因触发植物防御反应,序列多样化允许进化的等位基因逃避宿主检测,同时保留毒力功能。 研究人员将采用遗传筛选和生化分析来比较HopZ 1等位基因变体的宿主蛋白质相互作用谱,并确定参与军备竞赛的重要植物参与者,以了解序列多样化使能的效应子进化。 从这项研究中获得的新知识将有助于开发可持续的方法来控制细菌性疾病和提高食品安全。 该项目将对教育、外联和科学研究产生广泛影响。 它将为本科生、研究生和博士后研究人员,特别是代表性不足的少数群体和第一代大学生提供全面的培训和教育活动。 该项目产生的新知识将以期刊文章、会议记录和网站帖子的形式及时传播给科学界,并通过研究人员对本科生和研究生的教学活动传播给广大受众。

项目成果

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Wenbo Ma其他文献

Catalytic transformation of glycerol to 1-propanol by combining zirconium phosphate and supported Ru catalysts
磷酸锆与负载Ru催化剂组合催化甘油转化为1-丙醇
  • DOI:
    10.1039/c6ra02682f
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    Mengpan Wang;Hanmin Yang;Yinzheng Xie;Xiaohui Wu;Chen Chen;Wenbo Ma;Qifeng Dong;Zhenshan Hou
  • 通讯作者:
    Zhenshan Hou
Enhanced anti-tumor immunity generated by Rituximab-coated tumor cell vaccine.
利妥昔单抗包被的肿瘤细胞疫苗产生增强的抗肿瘤免疫力。
  • DOI:
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
    Huili Wang;Dongmei Wang;Mengqiang Li;Chunxiao Zhou;Wenbo Ma;Xiaosan Su;Rongzhi Liu;Shu
  • 通讯作者:
    Shu
Cancer stem cells sustaining the growth of mouse melanoma are not rare.
维持小鼠黑色素瘤生长的癌症干细胞并不罕见。
  • DOI:
    10.1016/j.canlet.2009.10.021
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
    Yong Zhong;Kaopeng Guan;Chunxiao Zhou;Wenbo Ma;Dongmei Wang;Youhui Zhang;Shu
  • 通讯作者:
    Shu
Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation
Epsin2,通过 α-突触核蛋白/FABP7 增殖治疗多系统萎缩的新靶点
  • DOI:
    10.1101/2022.06.16.496509
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    An Cheng;I. Kawahata;Yifei Wang;Wenbin Jia;Tomoki Sekimori;Yi Chen;N. Stefanova;D. Finkelstein;Wenbo Ma;Min Chen;T. Sasaki;K. Fukunaga
  • 通讯作者:
    K. Fukunaga
Ruthenium(II)‐Catalyzed Selective C(emsp/emsup2/sup)−H Acyloxylation of 2‐Aroyl‐Pyridine Derivatives with Sodium Carboxylate
钌(Ⅱ)催化的 2 -芳酰基吡啶衍生物与羧酸钠的选择性 C(2)-H 酰氧基化反应
  • DOI:
    10.1002/adsc.202301005
  • 发表时间:
    2024-02-19
  • 期刊:
  • 影响因子:
    4.000
  • 作者:
    Wenbo Ma;Tao Zheng;Linghui Gu
  • 通讯作者:
    Linghui Gu

Wenbo Ma的其他文献

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{{ truncateString('Wenbo Ma', 18)}}的其他基金

Mechanisms of siRNA mediated broad-spectrum resistance to eukaryotic pathogens
siRNA介导的对真核病原体广谱抗性的机制
  • 批准号:
    BB/W00691X/1
  • 财政年份:
    2022
  • 资助金额:
    $ 52.96万
  • 项目类别:
    Research Grant
The mechanism of trans-kingdom sRNA trafficking in plant-pathogen interactions
植物-病原体相互作用中跨界sRNA运输的机制
  • 批准号:
    EP/X022846/1
  • 财政年份:
    2022
  • 资助金额:
    $ 52.96万
  • 项目类别:
    Fellowship
Characterization of a conserved structural and functional module in Phytophthora effectors
疫霉效应子中保守结构和功能模块的表征
  • 批准号:
    BB/W016788/1
  • 财政年份:
    2022
  • 资助金额:
    $ 52.96万
  • 项目类别:
    Research Grant
Targeting a conserved structural module in Phytophthora effectors for disease resistance
针对疫霉效应子中的保守结构模块进行抗病
  • 批准号:
    1758889
  • 财政年份:
    2018
  • 资助金额:
    $ 52.96万
  • 项目类别:
    Continuing Grant

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阐明血清素能迷幻药抗抑郁作用的神经和分子基础
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