G-protein Regulation of Phenylalanine Synthesis

苯丙氨酸合成的 G 蛋白调节

• 批准号: 0848113
• 负责人: Katherine Warpeha
• 金额: $ 33.77万
• 依托单位: University of Illinois at Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848113&HistoricalAwards=false
• 关键词: protein; Regulation; Phenylalanine; Synthesis

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Scientific Merit: Seedlings have little or no protection against non-biotic stresses present in the environment (i.e. heat, ultraviolet sunlight [UV], salt, etc). The initial components of the sensing mechanisms that control tolerance to specific stresses remain unknown. It is therefore important to develop an understanding of how signal transduction systems within the seedling are activated by environmental stresses. The project will study the signal transduction system(s) that operates to produce the amino acid phenylalanine. Phenylalanine in turn serves as the precursor to many compounds that have a role in protecting plants against environmental stress. This signal transduction system appears to act in concert with several plant hormones known to have a role in how plants respond to environmental stress. The research will be conducted using Arabidopsis, a model plant organism, wherein each step of the signaling pathway that leads to the synthesis of the amino acid phenylalanine can be studied in detail. Broader Impact. Dissecting and understanding a simple stress-induced signaling pathway allows for the participation of undergraduate students as researchers and as authors on publications. Understanding this basic "stress cassette" in a young plant will allow researchers to evaluate many stresses with respect to their signaling pathways, their relationship to known stress-reported plant hormones and the specific compounds they direct the plant to produce. This is an important broader impact as much of crop loss worldwide arises from stresses incurred within the first two weeks after seeds are planted. The available arable land, both urban and rural, is decreasing, and the levels of environmental stressors are greater than ever before. Understanding how stresses are perceived is relevant for crop breeding, crop productivity, range management and the propagation of healthier foodstuffs.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。科学价值：幼苗对环境中存在的非生物胁迫（即热，紫外线阳光[UV]，盐等）几乎没有保护作用。控制对特定应力的耐受性的传感机制的初始组件仍然未知。因此，重要的是要了解如何在幼苗内的信号转导系统被激活的环境压力。该项目将研究产生氨基酸苯丙氨酸的信号转导系统。苯丙氨酸反过来又是许多化合物的前体，这些化合物在保护植物免受环境胁迫方面发挥作用。这种信号转导系统似乎与几种已知在植物如何应对环境胁迫中起作用的植物激素协同作用。该研究将使用模式植物拟南芥进行，其中可以详细研究导致氨基酸苯丙氨酸合成的信号通路的每个步骤。 更广泛的影响。解剖和理解一个简单的压力诱导的信号通路允许参与的本科生作为研究人员和作者的出版物。了解这种基本的“压力盒”在一个年轻的植物将允许研究人员评估许多压力方面的信号通路，它们的关系，已知的压力报告的植物激素和特定的化合物，他们指导植物生产。 这是一个重要的更广泛的影响，因为全世界大部分作物损失都是由于种子播种后头两周内发生的压力造成的。城市和农村的可耕地正在减少，环境压力比以往任何时候都大。了解如何感知压力与作物育种、作物生产力、牧场管理和更健康食品的传播有关。