Large-scale integrated microfluidic circuits based on intrinsically active polymers

该项目的总体目标是质疑可扩展大规模集成电路的基本原理，并基于新的理解，推导出能够满足可扩展性和后续功能多样化要求的微流体电路概念。这应该通过自上而下和自下而上相结合的办法来实现。一方面，应定义理想系统所需的系统特性，另一方面，将研究基于固有活性聚合物的平台的功能技术能力。将两种方法的结果相匹配将允许推导出一个可实现的概念。两个芯片的概念将解决：（a）集成电路与固定通道结构和（B）电路与可重构电路结构。为了建立基于本征活性聚合物的可扩展大规模集成电路概念的主要特征，必须完成相当广泛的子任务。在该研究项目的前期工作中，开发了有源组件的材料基础，流体回路的可扩展制造技术的主要特征，可行的系统和芯片架构以及组件的概念。另外，可以调节光电热控制器，以便能够控制微流体芯片。此外，还开发了基于临床化学的血液参数诊断研究的化学检测反应，适用于使用IC进行。这些检测反应用作微流体回路的任务的示例性制定。在剩余的6个月资助期内，用于血液参数诊断研究的化学检测反应将转化为回路程序，并将研究必要的单元操作和基本回路。关于可重构平台，将执行包括系统和芯片架构以及分别支持无源连接结构或通道结构的自由配置的技术构造开发的任务。所请求的供资期的目的是成功完成总体目标的剩余任务。该项目先前取得的进展适合作为今后有关大规模集成电路具体方面工作的基础。进一步的任务部分取决于电路的类型。虽然具有固定通道结构的电路的第一个重点将是大规模电路的方法，但可重新配置的IC将从解决组件的有源结构，基本和大规模电路的概念以及IC现场编程的主要特征开始。对于这两种类型的电路，主要的兴趣点将是基于计算机的电路设计和应用研究的基础上，血液化学的基础。

The projects overall target is to question the fundamentals of scalable large-scale integrated circuits and, based on the new understanding, to derive a concept for microfluidic circuits that will be able to fulfill the requirements for scalability and subsequent functional diversification. This should be achieved through a combined top-down and bottom-up approach. On the one hand, the required system characteristics of an ideal system shall be defined, on the other hand, functional-technological capabilities of a platform based on intrinsically active polymers will be investigated. Matching the findings of both methods will allow to deduce a realizable concept. Two chip concepts will be addressed: (a) integrated circuits with fixed channel structures and (b) circuits with reconfigurable circuit structures. In order to establish the main features of the concept of scalable large-scale integrated circuits based on intrinsically active polymers, a fairly broad spectrum of subtasks has to be accomplished. In previous works of the research project, the material base of the active components, the main features of a scalable manufacturing technology for the fluidic circuits, feasible system and chip architectures as well as concepts for components were developed. Additionally, the opto-electro-thermic controller could be adjusted so as to be able to control microfluidic chips. Furthermore, chemical detection reactions for diagnostic investigations of blood parameters based on clinical chemistry suitable to be performed with ICs were developed. These detection reactions serve as exemplary formulation of tasks for the microfluidic circuits. During the remaining 6 month of the granted funding period, the chemical detection reactions for diagnostic investigations of blood parameters will be transformed into circuit programs and the necessary unit operations and basic circuits will be investigated. Regarding the reconfigurable platforms, tasks including system and chip architecture as well as technological-constructional developments supporting a free configuration of passive connecting structures or channel structures respectively will be performed. Aim of the requested funding period is to complete the remaining tasks of the overall goal successfully. The previously achieved status of the project is suitable to serve as foundation for future works regarding specific aspects of large-scale integrated circuits. Further tasks partly depend on the type of the circuit. Whereas a first focus of circuits with fixed channel structures will be on approaches for large-scale circuits, reconfigurable ICs will start with addressing active structures of components , concepts for basic and large-scale circuits as well as main features of IC field programming. For both types of circuits, main points of interest will be the fundamentals of a computer-based circuit design and application studies on the basis of blood chemistry.