Investigations of the Size Effects on the Relaxation Rates of Polymer Coated Magnetic Nanoparticles for Hyperthermia

ID: MPS/DMR/BMAT(7623) 0907167 PI: Mefford, Olin T. ORG: Clemson university标题：尺寸对高温下聚合物包覆磁性纳米颗粒弛豫率的影响研究学术价值：PI建议研究影响纳米级聚合物包覆磁性氧化物颗粒磁热疗的因素。磁性颗粒从施加的电磁辐射中获得热能，如果这些颗粒可以靶向癌细胞，则可以通过将这些细胞加热到中等温度（40°C）而不伤害周围组织来杀死它们。粒子-涂层复合物对交变电磁场的响应速率与其弛豫时间有关，而控制这种行为的材料问题尚不完全清楚。拟议研究的一个主要目标是获得对松弛机制的基本理解。磁芯和聚合物稳定层的尺寸对材料对电磁辐射的响应有很大影响。然而，这两个维度的比值如何影响不同磁场和场频率下的热响应还不是很清楚。PI建议开发包覆和非包覆磁性纳米颗粒的模型系统，测量核心颗粒和聚合物/颗粒复合物的大小和大小分布如何影响悬浮液的弛豫速率，测量不同纳米颗粒系统在与人体相似的溶剂系统中的加热速率，并定制磁芯和聚合物刷的大小，以优化特定加热频率和场下的加热。更广泛的影响：提案的主题是当前感兴趣的，将有大量机会在会议和出版物中传播结果。这项工作为制药公司开发新的基于纳米粒子的疗法和显像剂提供了基础。一个成功的结果不仅会影响热疗研究，而且会影响磁学、聚合物化学和胶体化学。该项目是物理、化学和生物的交叉学科，为学生提供了一个跨学科训练的平台。除了该项目的研究生外，它还将为两名本科生提供研究机会。良好的写作和口头表达能力的发展对未来科学家和工程师的发展至关重要。该项目的目标之一是为学生提供在国内和国际会议上展示他们的作品的机会。PI将参加j.e. Sirrine暑期项目，该项目旨在让南卡罗来纳州的高中生接触材料科学研究。预计他的小组将指导其中两名学生。这项工作的目标之一是为克莱姆森大学的代表开发教学工具，以便他们穿越东南部，向高中生传授生物纳米材料的研究。

ID: MPS/DMR/BMAT(7623) 0907167 PI: Mefford, Olin T. ORG: Clemson UniversityTitle: Investigations of the Size Effects on the Relaxation Rates of Polymer Coated Magnetic Nanoparticles for HyperthermiaINTELLECTUAL MERIT: The PI proposes to investigate the factors affecting magnetic hyperthermia in nano-scale polymer-coated magnetic oxide particles. Magnetic particles acquire thermal energy from applied electromagnetic radiation and if the particles can be targeted into cancerous cells these cells can be killed by heating them to moderate temperatures ( 40 °C) without harming the surrounding tissue. The rate of response of the particle-coating complex to an alternating electromagnetic (EM) field is related to its relaxation time, and the materials issues that govern this behavior are not fully understood. A major objective of the proposed research is the acquisition of a fundamental understanding of the relaxation mechanisms. The sizes of the magnetic core and polymeric stabilizing layer can both greatly influence the response of these materials to EM radiation. However, it is not well understood how the ratio of these two dimensions affects the thermal response to different magnetic fields and field frequencies. The PI proposes to develop model systems of coated and non-coated magnetic nanoparticles, measure how the sizes and size distributions of the core particles and the polymer/particle complexes affect the relaxation rates of the suspensions, measure the heating rates of different nanoparticle systems in solvent systems similar to those found in the human body and tailor the sizes of the magnetic core and the polymer brushes to optimize heating at specific heating frequencies and fields.BROADER IMPACTS: The topic of the proposal is of current interest, and there will be abundant opportunities for dissemination of results in conferences and in publications. The work provides a foundation for pharmaceutical companies to develop new nanoparticle-based therapies and imaging agents. A successful outcome will impact not only hyperthermia research but also magnetism, polymer chemistry, and colloid chemistry. This project is at the intersection of physics, chemistry, and biology and thus provides a platform for interdisciplinary training of students. In addition to the graduate students on the project, it will provide opportunities for two undergraduate research students. The development of good writing and oral presentation skills is critical for the development of future scientists and engineers. One of the goals of the project is to provide opportunities for the students to present their work at national and international meetings. The PI will participate in the J. E. Sirrine Summer Program that exposes South Carolina high-school students to materials science research. It is expected that his group will mentor two of these students. One of the goals of this work is to develop teaching tools for Clemson representatives to travel across the Southeast to educate high school students on research in bionanomaterials.