Investigations of the Size Effects on the Relaxation Rates of Polymer Coated Magnetic Nanoparticles for Hyperthermia

热疗用聚合物包覆磁性纳米颗粒弛豫率的尺寸效应研究

• 批准号: 0907167
• 负责人: Olin Mefford
• 金额: $ 29万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0907167&HistoricalAwards=false
• 关键词: Investigations; Size; Effects; Relaxation; Rates

ID: MPS/DMR/BMAT(7623) 0907167 PI: Mefford, Olin T. ORG: Clemson UniversityTitle: Investigations of the Size Effects on the Relaxation Rates of Polymer Coated Magnetic Nanoparticles for HyperthermiaINTELLECTUAL MERIT: The PI proposes to investigate the factors affecting magnetic hyperthermia in nano-scale polymer-coated magnetic oxide particles. Magnetic particles acquire thermal energy from applied electromagnetic radiation and if the particles can be targeted into cancerous cells these cells can be killed by heating them to moderate temperatures ( 40 °C) without harming the surrounding tissue. The rate of response of the particle-coating complex to an alternating electromagnetic (EM) field is related to its relaxation time, and the materials issues that govern this behavior are not fully understood. A major objective of the proposed research is the acquisition of a fundamental understanding of the relaxation mechanisms. The sizes of the magnetic core and polymeric stabilizing layer can both greatly influence the response of these materials to EM radiation. However, it is not well understood how the ratio of these two dimensions affects the thermal response to different magnetic fields and field frequencies. The PI proposes to develop model systems of coated and non-coated magnetic nanoparticles, measure how the sizes and size distributions of the core particles and the polymer/particle complexes affect the relaxation rates of the suspensions, measure the heating rates of different nanoparticle systems in solvent systems similar to those found in the human body and tailor the sizes of the magnetic core and the polymer brushes to optimize heating at specific heating frequencies and fields.BROADER IMPACTS: The topic of the proposal is of current interest, and there will be abundant opportunities for dissemination of results in conferences and in publications. The work provides a foundation for pharmaceutical companies to develop new nanoparticle-based therapies and imaging agents. A successful outcome will impact not only hyperthermia research but also magnetism, polymer chemistry, and colloid chemistry. This project is at the intersection of physics, chemistry, and biology and thus provides a platform for interdisciplinary training of students. In addition to the graduate students on the project, it will provide opportunities for two undergraduate research students. The development of good writing and oral presentation skills is critical for the development of future scientists and engineers. One of the goals of the project is to provide opportunities for the students to present their work at national and international meetings. The PI will participate in the J. E. Sirrine Summer Program that exposes South Carolina high-school students to materials science research. It is expected that his group will mentor two of these students. One of the goals of this work is to develop teaching tools for Clemson representatives to travel across the Southeast to educate high school students on research in bionanomaterials.

ID：MPS/DMR/BMAT（7623）0907167 PI：Mefford，Olin T. ORG：克莱姆森大学聚合物涂层磁性纳米粒子用于高热的弛豫速率的尺寸效应的研究智力优势：PI建议研究影响纳米级聚合物涂层磁性氧化物粒子中的磁热疗的因素。磁性粒子从施加的电磁辐射中获得热能，如果粒子可以靶向癌细胞，则可以通过将其加热到中等温度（40 °C）来杀死这些细胞，而不会伤害周围组织。粒子涂层复合物对交变电磁场的响应速率与其弛豫时间有关，而控制这种行为的材料问题尚未完全了解。拟议的研究的一个主要目标是收购的松弛机制的基本理解。磁芯和聚合物稳定层的尺寸都可以极大地影响这些材料对EM辐射的响应。然而，这两个维度的比率如何影响对不同磁场和场频率的热响应还没有很好地理解。PI建议开发涂层和非涂层磁性纳米颗粒的模型系统，测量核心颗粒和聚合物/颗粒复合物的尺寸和尺寸分布如何影响悬浮液的弛豫速率，测量不同纳米颗粒系统在溶剂系统中的加热速率，类似于在人体中发现的那些，并定制磁芯和聚合物刷的尺寸，以优化在更广泛的重要性：建议的主题是当前感兴趣的，并且将有大量的机会在会议和出版物中传播结果。 这项工作为制药公司开发新的基于纳米颗粒的疗法和成像剂提供了基础。 一个成功的结果将不仅影响热疗研究，而且磁性，聚合物化学和胶体化学。 该项目是在物理，化学和生物学的交叉点，从而为学生的跨学科培训提供了一个平台。 除了该项目的研究生外，还将为两名本科研究生提供机会。 良好的写作和口头表达能力的发展对未来科学家和工程师的发展至关重要。该项目的目标之一是为学生提供在国家和国际会议上介绍其工作的机会。 PI将参加J.E.让南卡罗来纳州的高中生接触材料科学研究的暑期项目。预计他的小组将指导其中两名学生。这项工作的目标之一是为克莱姆森的代表开发教学工具，让他们穿越东南部，教育高中生进行生物纳米材料的研究。