Materials World Network: Dynamic Materials with Triggerable Adhesion Motifs

材料世界网络：具有可触发粘附图案的动态材料

• 批准号: 0909002
• 负责人: Andres Garcia
• 金额: $ 30万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2013-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0909002&HistoricalAwards=false
• 关键词: Materials; World; Network; Dynamic; Triggerable

This Materials World Network award by the Biomaterials program and the Office of Special Program in the Division of Materials Research to Georgia Institute of Technology supports an international collaboration for research and education between Georgia Tech (USA) and the Max-Planck Institut fur Polymerforschung (Germany). The objective of this project is to engineer phototriggerable materials to dynamically present and/or release bioadhesive motifs via the use of UV-labile caged bioadhesive ligands, which are expected to provide precise control over cell-material interactions both in vitro and in vivo. The project is to develop two biomaterial platforms (surfaces, hydrogels) with triggerable adhesive arginine-glycine-aspartic acid (RGD) tripeptide ligands in order to investigate the effects of spatiotemporal adhesion in cell processes. A major and unique strength of the proposed work is the ongoing international collaboration integrating photocaged chemistry and biomaterials engineering. The overall objective will be accomplished by completing the following specific aims: a) synthesize surfaces presenting caged RGD peptides that are activated or inactivated via exposure to UV light to spatiotemporally modulate cell adhesion; b) analyze the role of temporal ligand presentation on cell proliferation and differentiation on bioadhesive surfaces; c) engineer hydrogels presenting caged RGD peptides that exhibit spatiotemporal control of in vivo cell adhesion. These phototriggerable materials are expected to have wide-spread applications in basic-science studies of cell function as well as dynamic, tunable implants for tissue repair and regeneration. The proposed research will generate a general biomaterial strategy for precise spatiotemporal control of biological functionalities. These innovative biomaterials will then be used to provide new insights on cell-biomaterial interactions in vitro and in vivo. Furthermore, the focus on engineering triggerable hydrogels provides a pathway for translation into many biotechnological and biomedical applications. Because of these strengths, the proposed research will be highly transformative. Finally, this project will also strengthen the ongoing collaboration by enabling significant interactions and expanding research activities. The research will result in the advanced training of undergraduate and graduate researchers, including an underrepresented minority student from Georgia Tech, with unique analytical skills based on a multi-disciplinary, integrative perspective.

这项由乔治亚理工学院生物材料项目和材料研究部特别项目办公室颁发的材料世界网络奖，支持乔治亚理工学院（美国）和马克斯普朗克高分子研究所（德国）之间的国际研究和教育合作。该项目的目标是设计光触发材料，通过使用紫外线不稳定的笼状生物粘合剂配体来动态呈现和/或释放生物粘合剂基序，这有望在体外和体内对细胞-材料相互作用提供精确控制。该项目旨在开发两种具有可触发黏附精氨酸-甘氨酸-天冬氨酸（RGD）三肽配体的生物材料平台（表面、水凝胶），以研究细胞过程中时空黏附的影响。所提出的工作的一个主要和独特的优势是正在进行的整合光笼化学和生物材料工程的国际合作。总体目标将通过完成以下具体目标来实现：a)合成呈现通过暴露在紫外线下激活或灭活的笼状RGD肽的表面，以时空调节细胞粘附；B)分析时间配体呈现对生物粘附表面细胞增殖和分化的作用；c)工程水凝胶呈现笼化RGD肽，表现出对体内细胞粘附的时空控制。这些光触发材料有望广泛应用于细胞功能的基础科学研究，以及用于组织修复和再生的动态、可调谐植入物。提出的研究将产生一种通用的生物材料策略，用于精确的生物功能时空控制。然后，这些创新的生物材料将用于在体外和体内提供细胞-生物材料相互作用的新见解。此外，对工程可触发水凝胶的关注为转化为许多生物技术和生物医学应用提供了途径。由于这些优势，拟议的研究将具有高度的变革性。最后，该项目还将通过实现重要的互动和扩大研究活动来加强正在进行的合作。这项研究将为本科生和研究生研究人员提供高级培训，其中包括来自佐治亚理工学院的少数族裔学生，他们具有基于多学科综合视角的独特分析技能。