DISSERTATION RESEARCH: Experimental evolution of the cessation of aging

论文研究：停止衰老的实验演化

• 批准号: 0910362
• 负责人: Michael Rose
• 金额: $ 1.43万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0910362&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Experimental; evolution; cessation

In organisms that age, adulthood can be divided into two periods: 'aging,' during which mortality rates increase rapidly, and 'late life,' during which mortality rates plateau. Little is known about the physiology of late life, and in particular about whether functional stabilization occurs during late life. The planned research will test whether functional capacities shift in response to changes in the timing of late life using laboratory fruit flies as a model system. Two sets of populations that differ significantly with respect to the age of onset of late life will be compared for mobility and resistance to stress during the transition from aging to late life. The discovery of the cessation of aging late in adult life has significant implications for government agencies that need to know how best to care for the elderly. Understanding the functional significance of late life will be important for projections of health and social costs associated with aging. Governmental decision-making that involves projecting future changes in life expectancy and disability needs to be based on valid scientific information concerning the functional effects of the cessation of aging. The project will support a female graduate student and fourteen undergraduate students who are mentored by the co-PI and will design and implement project in experimental evolution.

在衰老的生物体中，成年期可分为两个阶段：“衰老”时期，死亡率迅速增加；“晚年”，死亡率趋于稳定。人们对晚年的生理学知之甚少，特别是晚年是否会发生功能稳定。 计划中的研究将使用实验室果蝇作为模型系统，测试功能能力是否会随着晚年时间的变化而发生变化。 将比较两组在晚年开始年龄方面存在显着差异的人群在从老龄化到晚年过渡期间的活动能力和抗压力能力。 成年晚期停止衰老的发现对于需要了解如何最好地照顾老年人的政府机构具有重大意义。 了解晚年的功能意义对于预测与衰老相关的健康和社会成本非常重要。 涉及预测预期寿命和残疾的未来变化的政府决策需要基于有关停止衰老的功能影响的有效科学信息。该项目将支持一名女研究生和十四名本科生，她们由联合 PI 指导，设计和实施实验进化项目。