Studies on the immune function of human slan-dendritic cells in psoriasis (N)

人slan树突状细胞在银屑病中免疫功能的研究（中）

• 批准号: 193242485
• 金额: --
• 依托单位: Universitäts-Hautklinik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/193242485?language=en
• 关键词: Studies; immune; function; human; slan

Psoriasis is a chronic immune mediated skin disease regulated by dendritic cells (DCs). Our studies reveal the functional and molecular specialization of slanDCs in psoriasis. With the next funding period we want to study details of the proinflammatory potential of slanDCs in vivo using the model of human psoriasis skin grafted to immunodeficient mice, the functional relevance of genes overexpressed in slanDCs in psoriasis, and finally, the frequency, the location, and the cellular partners of slanDCs in neutrophil rich pustular versus chronic plaque psoriasis.

银屑病是一种由树突状细胞(DC)调节的慢性免疫性皮肤病。我们的研究揭示了slanDC在银屑病中的功能和分子特化。随着下一个资助期的到来，我们希望使用人牛皮癣皮肤移植到免疫缺陷小鼠的模型来研究slanDC在体内的促炎潜能，银屑病中slanDC过度表达的基因的功能相关性，最后，在中性粒细胞丰富的脓疱性银屑病和慢性斑块型银屑病中slanDC的频率、位置和细胞伙伴。