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Modeling the Locomotion of the African Trypanosome

模拟非洲锥虫的运动

基本信息

批准号：
193560768
负责人：
Professor Dr. Holger Stark
金额：
--
依托单位：
Institut für Theoretische Physik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/193560768?language=en
关键词：
Modeling Locomotion African Trypanosome

项目摘要

Nature provides microorganisms with a wealth of ingenious solutions thatenable them to move through a fluid environment without using inertia.The strategies developed have relevance not only in biology, but alsoin medical and technological applications. The microorganism African trypanosome swims with the help of a beating filament, known as flagellum, that is firmly attached to the elongated cell body.There has recently been strong experimental evidence that the fluid flowinitiated by swimming is intimately linked with the ability of the trypanosome to evade the immune system. Since the trypanosome is the cause of sleeping sickness in humans, there is immense interest in investigating all details of the organism's lifecycle. In the preceding two years of this project, we have developed a model for the African trypanosome including a combination of straight and helical attachment of the actuating flagellum. With the model trypanosome we are able to simulate realistic swimming patterns and locomotion in narrow microchannels by treating the fluid environment with the help of the mesoscopic method of multi-particle collision dynamics. In the remaining third year we plan tostudy the behavior of the trypanosome under different experimental situations.In particular, we will look at locomotion in a model viscoelastic environment whichserves as a first approach for blood vessels filled with blood cells. Finally, we also aim at a first study of the collective motion of trypanosomes.

大自然为微生物提供了丰富的巧妙解决方案，使它们能够在不使用惯性的情况下在流体环境中移动。所开发的策略不仅与生物学相关，而且与医学和技术应用相关。微生物非洲锥虫借助一根跳动的丝（称为鞭毛）游泳，鞭毛牢固地附着在细长的细胞体上。最近有强有力的实验证据表明，游泳引发的液体流动与锥虫逃避免疫系统的能力密切相关。由于锥虫是导致人类昏睡病的原因，因此人们对研究该生物体生命周期的所有细节产生了极大的兴趣。在该项目的前两年中，我们开发了非洲锥虫模型，包括驱动鞭毛的直线和螺旋附件的组合。借助锥虫模型，我们能够借助多粒子碰撞动力学介观方法处理流体环境，从而模拟狭窄微通道中真实的游泳模式和运动。在剩下的第三年里，我们计划研究锥虫在不同实验情况下的行为。特别是，我们将研究粘弹性环境模型中的运动，这是填充血细胞的血管的第一种方法。最后，我们的目标还在于首次研究锥虫的集体运动。