MRI: Acquisition of a Time-Resolved Fluorescence Instrument for Chemistry Research and Education

MRI：购买用于化学研究和教育的时间分辨荧光仪器

• 批准号: 0922904
• 负责人: Patrick Hare
• 金额: $ 6.42万
• 依托单位: NORTHERN KENTUCKY UNIVERSITY RESEARCH FOUNDATION (DO NOT USE)
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0922904&HistoricalAwards=false
• 关键词: MRI; Acquisition; Time; Resolved; Fluorescence

With this award from the Major Research Instrumentation (MRI) program, Professor Patrick M. Hare and his colleagues Stefan Paula and Keith A. Walters will upgrade a fluorometer to a picosecond time-resolved, variable excitation wavelength instrument that will enhance both the research and education programs at Northern Kentucky University. Three areas of research will be benefit from the new capability: 1) Organometallic Supramolecular Chemistry of Fullerene-Transition Metal Systems; 2) Spectroscopic Characterization of Novel Inhibitors of the Sarco/endoplasmic Reticulum ATPase (SERCA); and 3) Photophysics of Endocrine Disrupting Compounds. Emission lifetime fluorescence spectrophotometers measure the time decay of the light emitted from a sample that has been promoted to an excited state by a light source. This provides insight on the mechanisms of energy transfer and loss in chemical and biological systems. It can reveal information on how substrates interact with enzymes or new materials can be used in solar cells, among other possible applications. The instrument will be used in research and laboratory classes by undergraduate students.

有了这个奖项从主要研究仪器（MRI）计划，教授帕特里克M。Hare和他的同事Stefan Paula和基思A.沃尔特斯将把荧光计升级为皮秒时间分辨、可变激发波长的仪器，这将加强北方肯塔基州大学的研究和教育项目。 三个研究领域将受益于新的能力：1）富勒烯-过渡金属体系的有机物超分子化学; 2）Sarco/内质网ATP酶（SERCA）新型抑制剂的光谱表征;和3）内分泌干扰化合物的光物理学。 发射寿命荧光光度计测量从样品发射的光的时间衰减，所述样品已经被光源提升到激发态。 这提供了对化学和生物系统中能量转移和损失机制的见解。 它可以揭示底物如何与酶相互作用的信息，或者可以用于太阳能电池的新材料，以及其他可能的应用。 该仪器将用于本科生的研究和实验室课程。