Accelerated Degradation of Active Nanosystems by Biomolecular Motors
生物分子马达加速活性纳米系统的降解
基本信息
- 批准号:0926790
- 负责人:
- 金额:$ 33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-01 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The research objective of this award is to develop an understanding of the degradation pathways of active nanosystems. At the macroscale, a car engine will rust when inactive, but wear out when running. Similarly, active nanosystems which incorporate mechanical motion degrade faster when activated. This project will utilize molecular shuttles, nanoscale transport systems powered by the motor protein kinesin, as a model system. Microfabricated guiding structures will be used to exert defined, cyclic loads on the moving shuttles, and optical microscopy will be employed to observe the breaking of the central part of the shuttle. Investigating degradation within these active nanostructures explores new ground, since the molecular shuttle system is too large to be readily described in atomic-level terms of force-activated dissociation of single bonds, but too small to apply macroscopic concepts of wear and fatigue. Thus a mesoscale view of these systems on the nanoscale is required and will be developed through a combination of experiment,simulation, and theory. The result of this research will be an improved understanding of wear and fatigue at the nanoscale. This understanding is on one hand critical for the design of durable devices which can function for their intended lifetime without failure. On the other hand, degradation products may be released from the system, similar to the ?brake dust? created from brake pads in a car. To assess the potential environmental and toxicological impact of active nanosystems it is therefore important to understand how the nanosystem evolves over its lifetime and ultimately fails. While this research is only a first step towards understanding these complex processes, it will ? if successful ? create a template for the evaluation of other active nanosystems and provide a basic scientific framework to understand these degradation processes.
该奖项的研究目标是发展对活性纳米系统降解途径的理解。从宏观上看,汽车发动机在不活动时会生锈,但在运行时就会磨损。同样,包含机械运动的活性纳米系统在被激活时降解得更快。这个项目将利用分子穿梭,纳米级运输系统由马达蛋白驱动,作为一个模型系统。微制造的导向结构将对移动的航天飞机施加确定的循环载荷,光学显微镜将观察航天飞机中心部分的断裂。研究这些活性纳米结构中的降解是一个新的领域,因为分子穿梭系统太大,无法用单键力激活解离的原子水平来描述,但又太小,无法应用磨损和疲劳的宏观概念。因此,需要在纳米尺度上对这些系统进行中尺度观察,并将通过实验、模拟和理论的结合来发展。这项研究的结果将是在纳米尺度上提高对磨损和疲劳的理解。这种理解一方面对于设计能够在其预期寿命内正常工作的耐用设备至关重要。另一方面,降解产物可能从系统中释放出来,类似于?刹车灰尘?由汽车刹车片制成。因此,为了评估活性纳米系统的潜在环境和毒理学影响,了解纳米系统如何在其生命周期内进化并最终失效是很重要的。虽然这项研究只是了解这些复杂过程的第一步,但它会吗?如果成功了?创建一个评估其他活性纳米系统的模板,并提供一个基本的科学框架来理解这些降解过程。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Henry Hess其他文献
Microtubules function as mechanosensor to regulate intracellular transport
微管充当机械传感器来调节细胞内运输
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Syeda Rubaiya Nasrin;Christian Ganser;Seiji Nishikawa;Arif Md Rashedul Kabir;Kazuki Sada;Takefumi Yamashita;Mitsunori Ikeguchi;Takayuki Uchihashi;Henry Hess;Akira Kakugo;Akira Kakugo - 通讯作者:
Akira Kakugo
Cytoskeletal motor-driven active self-assembly in in vitro systems.
体外系统中细胞骨架电机驱动的主动自组装。
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:3.4
- 作者:
A. Lam;V. Vandelinder;A. Kabir;Henry Hess;G. Bachand;A. Kakugo - 通讯作者:
A. Kakugo
Velocity-dependence of Cargo Loading onto Molecular Shuttles Demonstrates the Glue-like Character of Biotin/Streptavidin
- DOI:
10.1016/j.bpj.2008.12.1588 - 发表时间:
2009-02-01 - 期刊:
- 影响因子:
- 作者:
Ashutosh Agarwal;Henry Hess - 通讯作者:
Henry Hess
わたしたちに音楽がある理由 (源 健宏、pp. 128-142)
我们拥有音乐的原因(Takehiro Minamoto,第 128-142 页)
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Syeda Rubaiya Nasrin;Christian Ganser;Seiji Nishikawa;Kazuki Sada;Takayuki Uchihashi;Henry Hess;Akira Kakugo;根ケ山光一・今川恭子・香田啓貴・関 義正・藤井進也・蒲谷槙介・石島このみ・服部裕子・高田 明・麦谷綾子・市川 熹・源 健宏・岸本 健・福山寛志・横井浩史・横井和恵・矢吹佳子・志村洋子・市川 恵・丸山 慎・伊原小百合・二俣 泉・小井塚ななえ・石川眞佐江・小川容子・本多佐保美 - 通讯作者:
根ケ山光一・今川恭子・香田啓貴・関 義正・藤井進也・蒲谷槙介・石島このみ・服部裕子・高田 明・麦谷綾子・市川 熹・源 健宏・岸本 健・福山寛志・横井浩史・横井和恵・矢吹佳子・志村洋子・市川 恵・丸山 慎・伊原小百合・二俣 泉・小井塚ななえ・石川眞佐江・小川容子・本多佐保美
High-Resolution Observation of the Effect of Deformation Microtubule on Single Kinesin Motility
变形微管对单个驱动蛋白运动影响的高分辨率观察
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Syeda Rubaiya Nasrin;Christian Ganser;Seiji Nishikawa;Kazuki Sada;Takayuki Uchihashi;Henry Hess;Akira Kakugo - 通讯作者:
Akira Kakugo
Henry Hess的其他文献
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{{ truncateString('Henry Hess', 18)}}的其他基金
EAGER: Towards a Homeostatic Nanobio-Hybrid Mechanical System
EAGER:迈向稳态纳米生物混合机械系统
- 批准号:
2230116 - 财政年份:2022
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
Creating Dynamic and Adaptive Force-Producing Nanostructures
创建动态和自适应力产生纳米结构
- 批准号:
1807514 - 财政年份:2018
- 资助金额:
$ 33万 - 项目类别:
Continuing Grant
Molecular-scale Breaking due to Repeated Loading in Molecular Shuttles
分子穿梭重复加载导致分子尺度断裂
- 批准号:
1662329 - 财政年份:2017
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
CAREER: Creating Materials via Active Self-Assembly Driven by Biomolecular Motors
职业:通过生物分子马达驱动的主动自组装创造材料
- 批准号:
1015486 - 财政年份:2009
- 资助金额:
$ 33万 - 项目类别:
Continuing Grant
CAREER: Creating Materials via Active Self-Assembly Driven by Biomolecular Motors
职业:通过生物分子马达驱动的主动自组装创造材料
- 批准号:
0645023 - 财政年份:2007
- 资助金额:
$ 33万 - 项目类别:
Continuing Grant
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