Nanoporous Silicon Optical Waveguide Cavities for Real-Time Biological Sensing

用于实时生物传感的纳米多孔硅光波导腔

• 批准号: 0932673
• 负责人: Thomas Murphy
• 金额: $ 31.68万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0932673&HistoricalAwards=false
• 关键词: Nanoporous; Silicon; Optical; Waveguide; Cavities

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).0932673MurphyThis NSF award by the Biosensing /CBET program supports work by Professor Murphy at University of Maryland College Park to develop a label-free biosensor that uses optical waveguides and resonant cavities comprised of nanoporous silicon. Nanoporous silicon is a unique material with several features that make it attractive for biological sensors, including a very high surface area to volume ratio, simple and inexpensive fabrication techniques, and suitability for integration with silicon electronics. The proposed sensor is designed to measure small changes in the refractive index of porous silicon waveguides that occur when biological molecules attach to the internal surfaces. In addition to the promise of improved sensitivity, this approach could be faster and less expensive than conventional techniques that require fluorescent labels. As a target application, they will explore the possibility of detecting prions, the protein molecules responsible for transmissible spongiform encephalopathies.Beyond these intellectual goals, the project will also provide summer research opportunities for undergraduate students, mentoring for high-school students, and will promote multidisciplinary collaboration between chemists, biologists and optical engineers.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。0932673墨菲该NSF奖由生物传感/CBET计划支持墨菲教授在马里兰州大学帕克分校的工作，以开发一种无标记的生物传感器，使用光波导和纳米多孔硅组成的谐振腔。 纳米多孔硅是一种独特的材料，具有几个特征，使其对生物传感器具有吸引力，包括非常高的表面积与体积比，简单而廉价的制造技术，以及适合与硅电子集成。 所提出的传感器被设计用于测量当生物分子附着到内表面时发生的多孔硅波导的折射率的微小变化。 除了提高灵敏度的承诺，这种方法可能比需要荧光标记的传统技术更快，更便宜。 作为一个目标应用，他们将探索检测朊病毒的可能性，朊病毒是导致传染性海绵状脑病的蛋白质分子。除了这些智力目标，该项目还将为本科生提供暑期研究机会，为高中生提供指导，并将促进化学家，生物学家和光学工程师之间的多学科合作。