EAGER: Chemistry of Water-Intolerant Intermediates...in Water

EAGER：水中不耐水中间体的化学...

• 批准号: 0937658
• 负责人: Bruce Lipshutz
• 金额: $ 20万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0937658&HistoricalAwards=false
• 关键词: EAGER; Chemistry; Water; Intolerant; Intermediates...in

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project will initiate work on the development of methods for two unprecedented reactions: (1) in situ Grignard formation and use in cross-coupling reactions in water, and (2) formation of unstabilized ylides for Wittig-like olefinations, also in water. These will take advantage of micellar catalysis, where the reactive species to be generated either on the surface of the metal, or within a micelle, are protected from their aqueous surroundings by the hydrophobic interior of these nanoparticles. For these studies, many variables will need to be screened, including the nature of the amphiphile that is to supply a dry reaction medium, in water.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Bruce H. Lipshutz of the Department of Chemistry at the University of California, Santa Barbara. Professor Bruce Lipshutz's research efforts revolve around the development of new synthetic methods for the formation of C-C, C-H, C-O, and C-N bonds. Such chemistry will contribute to environmentally benign methods for chemical synthesis, as these new processes will be developed in the absence of organic solvents. Successful development of the methodology will have an impact on synthesis in the pharmaceutical, fine chemicals, and agricultural industries.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。该项目将启动两种前所未有的反应方法的开发工作：(1)原位格氏形成并用于水中的交叉偶联反应；(2)形成不稳定的类维蒂格烯烃，也在水中。这将利用胶束催化的优势，其中在金属表面或胶束内产生的反应物质被这些纳米颗粒的疏水内部保护，不受水环境的影响。对于这些研究，需要筛选许多变量，包括在水中提供干燥反应介质的两亲性物质的性质。通过这个奖项，有机和大分子化学项目支持加州大学圣巴巴拉分校化学系Bruce H. Lipshutz教授的研究。Bruce Lipshutz教授的研究工作围绕着开发新的合成方法来形成C-C、C-H、C-O和C-N键。这种化学将有助于无害环境的化学合成方法，因为这些新工艺将在没有有机溶剂的情况下开发。该方法的成功发展将对制药、精细化学品和农业工业的合成产生影响。