EAGER: Chemistry of Water-Intolerant Intermediates...in Water

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。该项目将开始开发两种前所未有的反应的方法：(1)原位格氏反应并用于水中的交叉偶联反应，以及(2)在水中形成Wittig类烯化反应的不稳定叶立德。这将利用胶束催化，在金属表面或胶束内产生的反应物种通过这些纳米颗粒的疏水内部保护，使其免受水环境的影响。对于这些研究，需要筛选许多变量，包括在水中提供干燥反应介质的两亲分子的性质。有了这个奖项，有机和高分子化学计划支持加州大学圣巴巴拉分校化学系的布鲁斯·H·利普舒茨教授的研究。布鲁斯·利普舒茨教授的研究工作围绕着开发新的合成方法来形成C-C、C-H、C-O和C-N键。这种化学将有助于环境友好的化学合成方法，因为这些新工艺将在没有有机溶剂的情况下开发。该方法的成功开发将对制药、精细化学品和农业行业的合成产生影响。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project will initiate work on the development of methods for two unprecedented reactions: (1) in situ Grignard formation and use in cross-coupling reactions in water, and (2) formation of unstabilized ylides for Wittig-like olefinations, also in water. These will take advantage of micellar catalysis, where the reactive species to be generated either on the surface of the metal, or within a micelle, are protected from their aqueous surroundings by the hydrophobic interior of these nanoparticles. For these studies, many variables will need to be screened, including the nature of the amphiphile that is to supply a dry reaction medium, in water.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Bruce H. Lipshutz of the Department of Chemistry at the University of California, Santa Barbara. Professor Bruce Lipshutz's research efforts revolve around the development of new synthetic methods for the formation of C-C, C-H, C-O, and C-N bonds. Such chemistry will contribute to environmentally benign methods for chemical synthesis, as these new processes will be developed in the absence of organic solvents. Successful development of the methodology will have an impact on synthesis in the pharmaceutical, fine chemicals, and agricultural industries.