New Synthetic Methods Based on Group 4 Organometallic Intermediates

这项研究的重点是利用各种炔烃的标准锆化反应生成的有机锆试剂与铜(I)试剂，特别是高阶氰铜酸盐进行配体交换反应。由许多化合物生成的乙烯基锆烯，包括乙酰锡烷和乙酰醚，为多种C-C键结构提供了试剂。转金属化协议也将扩展到钛，并将启动对钛环丁烯的研究。核磁共振将被用来探测一些有趣的铜酸盐的聚集状态。%有了这一续期奖，合成有机计划将支持加州大学圣巴巴拉分校化学系的Bruce H.LipShuz博士的研究。利普舒茨教授将专注于开发新的合成方法，这些方法依赖于由铜(I)试剂组成的第4族金属组成的选定有机金属中间体的转金属化。这一研究将有助于制备高效的C-C成键试剂。

The focus of this research is to exploit organozirconium reagents, resulting from standard zirconations of various alkynes, for ligand exchange reactions with Cu(I) reagents, particularly higher order cyanocuprates. Vinyl zirconocenes generated from a number of compounds including acetylenic stannanes and acetylenic ethers afford reagents for multiple C-C bond constructions. The transmetalation protocol will also be extended to Ti and a study of titanacyclobutenes will be initiated. NMR will be used to probe the aggregation states of a number of interesting cuprates. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Bruce H. Lipshutz of the Department of Chemistry at the University of California, Santa Barbara. Professor Lipshutz will focus his work on developing new syntetic methods that rely on the transmetalations of selected organometallic intermediates composed of Group 4 metals with Cu(I) reagents. The research will lead to the facile preparation of efficient reagents for C-C bond making.