New Synthetic Methods Based on Group 4 Organometallic Intermediates

本研究的重点是利用各种炔的标准锆反应产生的有机锆试剂，与Cu(I)试剂进行配体交换反应，特别是高阶氰酸盐。乙烯基锆石是由许多化合物生成的，包括乙基锡烷和乙基醚，为构建多个C-C键提供了试剂。转化方案也将扩展到钛，并将开始对钛环丁烯的研究。核磁共振将被用来探测一些有趣的铜酸盐的聚集状态。有了这个更新奖，合成有机项目将支持加州大学圣巴巴拉分校化学系布鲁斯·h·利普舒茨博士的研究。Lipshutz教授将专注于开发新的合成方法，该方法依赖于由4族金属组成的选定有机金属中间体与Cu(I)试剂的金属转化。该研究将有助于制备高效的碳-碳键制备试剂。

The focus of this research is to exploit organozirconium reagents, resulting from standard zirconations of various alkynes, for ligand exchange reactions with Cu(I) reagents, particularly higher order cyanocuprates. Vinyl zirconocenes generated from a number of compounds including acetylenic stannanes and acetylenic ethers afford reagents for multiple C-C bond constructions. The transmetalation protocol will also be extended to Ti and a study of titanacyclobutenes will be initiated. NMR will be used to probe the aggregation states of a number of interesting cuprates. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Bruce H. Lipshutz of the Department of Chemistry at the University of California, Santa Barbara. Professor Lipshutz will focus his work on developing new syntetic methods that rely on the transmetalations of selected organometallic intermediates composed of Group 4 metals with Cu(I) reagents. The research will lead to the facile preparation of efficient reagents for C-C bond making.