New Synthetic Methods Based on Group 4 Organometallic Intermediates

本课题的研究重点是有机锆的开发利用 试剂，由各种标准锆化反应产生 炔，用于与Cu（I）试剂的配体交换反应， 特别是更高级的氰基铜酸盐。 乙烯基二茂锆 由许多化合物产生， 锡烷和炔醚提供了用于多个 C-C键结构。 金属转移协议还将 扩展到钛和钛环丁烯的研究将是 启动。 核磁共振将用于探测聚合状态 一些有趣的铜酸盐 %%% 有了这个更新奖，合成有机计划是 支持布鲁斯H.利普舒茨 加州大学化学系 芭芭拉 Lipshutz教授将把他的工作重点放在开发 新的合成方法依赖于 由第4族组成的选择的有机金属中间体 金属与Cu（I）试剂。 这项研究将导致 容易制备用于C-C键形成的有效试剂。

The focus of this research is to exploit organozirconium reagents, resulting from standard zirconations of various alkynes, for ligand exchange reactions with Cu(I) reagents, particularly higher order cyanocuprates. Vinyl zirconocenes generated from a number of compounds including acetylenic stannanes and acetylenic ethers afford reagents for multiple C-C bond constructions. The transmetalation protocol will also be extended to Ti and a study of titanacyclobutenes will be initiated. NMR will be used to probe the aggregation states of a number of interesting cuprates. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Bruce H. Lipshutz of the Department of Chemistry at the University of California, Santa Barbara. Professor Lipshutz will focus his work on developing new syntetic methods that rely on the transmetalations of selected organometallic intermediates composed of Group 4 metals with Cu(I) reagents. The research will lead to the facile preparation of efficient reagents for C-C bond making.