GOALI: SusChEM: A Collaboration on Catalysis between UCSB and Novartis

目标:SusChEM:UCSB 和诺华之间的催化合作

基本信息

  • 批准号:
    1566212
  • 负责人:
  • 金额:
    $ 45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-08-15 至 2019-07-31
  • 项目状态:
    已结题

项目摘要

The Chemical Catalysis Program in the Chemistry Division supports this Grant Opportunity for Academic Liaison with Industry (GOALI) award to Professor Bruce Lipshutz. Professor Lipshutz is a faculty member at the University of California, Santa Barbara (UCSB). The project is a collaboration between UCSB and Novartis, a pharmaceutical company. The research undertaken at UCSB focuses on developing new catalysts for valuable organic reactions, where the amount of precious metal, palladium, is only needed in parts per million, rather than the greater levels normally used in palladium-catalyzed reactions. These new reactions reduce the environmental footprint associated with industrial uses of palladium as the reactions are done in water, avoiding use of toxic, flammable, and costly organic solvents. The reagents and experiments under development are of general synthetic utility, and thus may have an impact in academic settings. Students in these research groups learn to couple industrial manufacturing with sustainable chemistry. New nanoparticles (NPs) are formed by treatment of inexpensive iron(III) trichloride (containing ca. 350 ppm palladium) and a phosphine ligand, with methyl Grignard at room temperature. The new iron nanoparticles (NPs) containing trace palladium metal (Pd) catalyze Suzuki-Miyaura cross-couplings reactions. Synthesis of the Novartis drug valsartan, which contains biaryl residue, is under development using this technology. These NPs are being investigated as catalysts for other important Pd-catalyzed reactions, such as Sonogashira couplings. The reactions are performed in water, thereby eliminating organic solvents as the reaction medium. The NPs can be recycled, effectively reducing not only the amount of Pd needed, but also the levels of residual metal found in the products. In addition, it has been found that these same iron nanoparticles, in the absence of ligand, are effective catalysts for the reduction of aromatic and heteroaromatic nitro groups in water. The reduction leads to the corresponding amine, which is a valuable transformation in the pharmaceutical industry. These new technologies are developed by graduate students, who receive their training both in synthetic organic chemistry and in green chemistry. The students involved in the project are develop the know how to minimize organic and metal waste in reaction development and scale-up.
化学系的化学催化项目支持布鲁斯·利普舒茨教授获得学术界与工业界联系(GOALI)奖。Lipshutz教授是加州大学圣巴巴拉分校(UCSB)的教员。 该项目是UCSB和诺华制药公司之间的合作。UCSB进行的研究重点是为有价值的有机反应开发新的催化剂,其中贵金属钯的量仅需百万分之一,而不是钯催化反应中通常使用的更高水平。这些新的反应减少了与钯的工业用途相关的环境足迹,因为反应在水中进行,避免使用有毒、易燃和昂贵的有机溶剂。正在开发的试剂和实验具有一般的合成效用,因此可能会在学术环境中产生影响。 这些研究小组的学生学习将工业制造与可持续化学结合起来。新的纳米颗粒(NP)是通过处理廉价的铁(III)氧化物(含有约100%)形成的。350 ppm钯)和膦配体与甲基Grignard在室温下反应。 新型含微量钯金属的铁纳米粒子催化Suzuki-Miyaura交叉偶联反应。诺华公司的药物缬沙坦(valsartan)含有联芳基残基,目前正在利用这一技术进行合成。这些纳米粒子正在研究作为其他重要的Pd催化反应,如Sonogashira耦合催化剂。反应在水中进行,从而消除了作为反应介质的有机溶剂。NP可以回收,不仅有效地减少了所需的Pd量,而且还减少了产品中残留金属的水平。此外,已经发现,这些相同的铁纳米颗粒在不存在配体的情况下是用于还原水中的芳香族和杂芳香族硝基的有效催化剂。 还原产生相应的胺,这在制药工业中是有价值的转化。这些新技术是由研究生开发的,他们接受了合成有机化学和绿色化学的培训。参与该项目的学生正在开发如何在反应开发和放大中最大限度地减少有机和金属废物的知识。

项目成果

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Bruce Lipshutz其他文献

Bruce Lipshutz的其他文献

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{{ truncateString('Bruce Lipshutz', 18)}}的其他基金

CAS: New Advances in Sustainable Catalysis
CAS:可持续催化的新进展
  • 批准号:
    2152566
  • 财政年份:
    2022
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
New Technologies in Organic Synthesis in Water
水中有机合成新技术
  • 批准号:
    1856406
  • 财政年份:
    2019
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
SusChEM: New Technologies Based on Organocopper Catalysis
SusChEM:基于有机铜催化的新技术
  • 批准号:
    1561158
  • 财政年份:
    2016
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
New Technologies Based on Organocopper Catalysis
基于有机铜催化的新技术
  • 批准号:
    0948479
  • 财政年份:
    2010
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
EAGER: Chemistry of Water-Intolerant Intermediates...in Water
EAGER:水中不耐水中间体的化学...
  • 批准号:
    0937658
  • 财政年份:
    2009
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Asymmetric Catalysis with Ligated Copper Hydride
连接氢化铜的不对称催化
  • 批准号:
    0550232
  • 财政年份:
    2006
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
New Technologies Based on Organocopper Chemistry
基于有机铜化学的新技术
  • 批准号:
    0213522
  • 财政年份:
    2002
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
New Synthetic Organometallic Chemistry
新金属有机合成化学
  • 批准号:
    9734813
  • 财政年份:
    1998
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
Support of Students Attending OMCOS 8, Santa Barbara, California, August 6-10, 1995
对参加 OMCOS 8(加利福尼亚州圣巴巴拉,1995 年 8 月 6 日至 10 日)的学生的支持
  • 批准号:
    9503303
  • 财政年份:
    1994
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
New Synthetic Methods Based on Group 4 Organometallic Intermediates
基于第4族有机金属中间体的新合成方法
  • 批准号:
    9303883
  • 财政年份:
    1993
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant

相似海外基金

Collaborative Research: SUSCHEM: Engineering Polymer-Nanocatalyst Membranes for Direct Capture of CO2 and Electrochemical Conversion to C2+ Liquid Fuel
合作研究:SUSCHEM:用于直接捕获 CO2 和电化学转化为 C2 液体燃料的工程聚合物纳米催化剂膜
  • 批准号:
    2324346
  • 财政年份:
    2023
  • 资助金额:
    $ 45万
  • 项目类别:
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Collaborative Research: SUSCHEM: Engineering Polymer-Nanocatalyst Membranes for Direct Capture of CO2 and Electrochemical Conversion to C2+ Liquid Fuel
合作研究:SUSCHEM:用于直接捕获 CO2 和电化学转化为 C2 液体燃料的工程聚合物纳米催化剂膜
  • 批准号:
    2324345
  • 财政年份:
    2023
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
SusChEM: Harnessing Stable Peroxides for Selective Nitrogen Atom and Fluoroalkyl Transfer
SusChEM:利用稳定的过氧化物进行选择性氮原子和氟烷基转移
  • 批准号:
    2200040
  • 财政年份:
    2022
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
CAREER: SusChEM: Iron Catalysts for the Reduction of Amides
职业:SusChEM:用于还原酰胺的铁催化剂
  • 批准号:
    2146728
  • 财政年份:
    2021
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
CAREER: SusChEM: Renewable Biocatalysts for Degradation of Persistent Organic Contaminants Using Synthetic Biology
职业:SusChEM:利用合成生物学降解持久性有机污染物的可再生生物催化剂
  • 批准号:
    2154345
  • 财政年份:
    2021
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
SusChEM: C-H Bond Electroactivation of Nonpolar Organic Substrates in Water: Enzyme-Mediated Reaction Pathways in Microemulsions
SusChEM:水中非极性有机底物的 C-H 键电活化:微乳液中酶介导的反应途径
  • 批准号:
    2035669
  • 财政年份:
    2021
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
CAREER: SusChEM: Copper-Catalyzed Aerobic Dehydrogenative C-C Bond Formation through sp3 C-H Bond Functionalization
职业:SusChEM:通过 sp3 C-H 键功能化铜催化有氧脱氢 C-C 键形成
  • 批准号:
    2028770
  • 财政年份:
    2020
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
SusChEM: Non-precious metal substitution into hydrogenation metal alloy catalysts deposited onto redox active supports for facile nitrate destruction in drinking water
SusChEM:用非贵金属替代沉积在氧化还原活性载体上的氢化金属合金催化剂,以轻松破坏饮用水中的硝酸盐
  • 批准号:
    1922504
  • 财政年份:
    2019
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
SusChEM: Collaborative Research: Identification of the critical length scales and chemistries responsible for the anti-fouling properties of heterogeneous surfaces
SusChEM:合作研究:确定负责异质表面防污性能的临界长度尺度和化学成分
  • 批准号:
    2023847
  • 财政年份:
    2019
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
SusChem Collaborative Research: Process Optimization of Novel Routes for the Production of bio-based Para-Xylene
SusChem 合作研究:生物基对二甲苯生产新路线的工艺优化
  • 批准号:
    2005905
  • 财政年份:
    2019
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
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