New Synthetic Organometallic Chemistry

拟议的研究涉及开发新的合成方法 涉及在催化浓度下使用的有机铜中间体。 反应将包括1）弗莱明的甲硅烷基铜酸盐化学，2）使用 镧系元素和其它稀土助催化剂，3）烷基化 具有乙烯基和芳基的官能化Zn和Zr试剂 三氟甲磺酸酯，和4）α，β-不饱和的1，4-还原 使用氢化铜络合物的羰基化合物。拉曼和 红外光谱和电喷雾质谱，将是 用于测定有机铜酸盐的组成和结构 在溶液中。 有了这个更新奖，有机和高分子 化学计划提供持续的支持， 医学系的布鲁斯·利普舒茨博士的研究 在圣巴巴拉的加州大学学习化学。 这项研究涉及合成方法的发展这项研究涉及合成方法的发展 用于在温和条件下制备有机化合物， 具有高选择性。 这项工作将提供宝贵的 对研究生和博士后研究员的培训， 的有机合成和光谱鉴定 反应中间体

The proposed research involves the development of new synthetic methods involving organocopper intermediates used at catalytic concentrations. Reactions will include 1) Fleming's silyl cuprate chemistry, 2)the use of lanthanide and other rare earth cocatalysts, 3) alkylations of functionalized Zn and Zr reagents with vinyl and aryl triflates, and 4)1,4-reductions of alpha,beta-unsaturated carbonyl compounds using copper hydride complexes. Raman and IR spectroscopy, and electrospray mass spectrometry, will be used to determine organocuprate compositions and structures in solution. With this renewal award, the Organic and Macromolecular Chemistry Program provides continuing support for the research of Dr. Bruce Lipshutz of the Department of Chemistry at the University of California at Santa Barbara. The research involves the developmentof synthetic methods for preparing organic compounds under mild conditions and with high selectivities. The work will provide valuable training to graduate students and post-doctoral fellows in organic synthesis and the spectroscopic identification of reaction intermediates.