New Synthetic Organometallic Chemistry

拟议的研究涉及开发新的合成方法，涉及在催化浓度下使用的有机铜中间体。反应将包括1)弗莱明的硅基铜化学，2)镧系元素和其他稀土助催化剂的使用，3)功能化Zn和Zr试剂与乙烯基和芳基三氟酸盐的烷基化，以及4)使用铜氢化配合物还原α， β不饱和羰基化合物的1,4。拉曼光谱和红外光谱以及电喷雾质谱法将用于确定溶液中的有机酸盐成分和结构。有了这个更新奖，有机和大分子化学项目为加州大学圣巴巴拉分校化学系Bruce Lipshutz博士的研究提供了持续的支持。本研究涉及在温和条件下制备高选择性有机化合物的合成方法的发展。这项工作将为有机合成和反应中间体的光谱鉴定方面的研究生和博士后提供有价值的培训。

The proposed research involves the development of new synthetic methods involving organocopper intermediates used at catalytic concentrations. Reactions will include 1) Fleming's silyl cuprate chemistry, 2)the use of lanthanide and other rare earth cocatalysts, 3) alkylations of functionalized Zn and Zr reagents with vinyl and aryl triflates, and 4)1,4-reductions of alpha,beta-unsaturated carbonyl compounds using copper hydride complexes. Raman and IR spectroscopy, and electrospray mass spectrometry, will be used to determine organocuprate compositions and structures in solution. With this renewal award, the Organic and Macromolecular Chemistry Program provides continuing support for the research of Dr. Bruce Lipshutz of the Department of Chemistry at the University of California at Santa Barbara. The research involves the developmentof synthetic methods for preparing organic compounds under mild conditions and with high selectivities. The work will provide valuable training to graduate students and post-doctoral fellows in organic synthesis and the spectroscopic identification of reaction intermediates.