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New Technologies Based on Organocopper Chemistry

基于有机铜化学的新技术

基本信息

批准号：
0213522
负责人：
Bruce Lipshutz
金额：
$ 44.3万
依托单位：
University of California-Santa Barbara
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2002
资助国家：
美国
起止时间：
2002-07-01 至 2005-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0213522&HistoricalAwards=false
关键词：
New Technologies Based Organocopper Chemistry

项目摘要

The main theme of this work is the use of copper (I) complexes to catalyze a variety of asymmetric organic reactions. Most of the proposed chemistry involves the catalytic use of asymmetrically ligated copper hydride or alkyl complexes. The copper hydrides will be used for asymmetric hydrosilylation of ketones and a 1,4-reducation-transmetallation protocol for converting alpha, beta unsaturated ketones into Z-boron enolates. The copper alkyl complexes will be used primarily for asymmetric 1,2 additions to aldehydes and to effect alkylative kinetic resolution of racemic epoxides.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Bruce H. Lipshutz of the Department of Chemistry at the University of California at Santa Barbara. Dr. Lipshutz will work on the development of copper complexes capable of catalyzing a number of chemical reactions. Most of these copper catalyzed carbon-hydrogen and carbon-carbon bond forming reactions produce molecules which are chiral (have two nonsuperimposable mirror images) and make only one of the two possible forms (a single enantiomer). Development of this family of reactions is one of the most important problems facing the pharmaceutical industry today. These transformations which are catalytic in copper may be amenable to large scale production of fine chemicals and pharmaceuticals. Students trained during the course of this work will gain skills needed by the pharmaceutical and speciality chemicals industries which now produce a number of single enantiomer compounds.

本工作的主要主题是使用铜（I）配合物催化各种不对称有机反应。大多数提议的化学涉及不对称连接的氢化铜或烷基络合物的催化使用。该铜催化剂将用于酮的不对称氢化硅烷化和用于将α，β不饱和酮转化为Z-硼烯醇化物的1，4-还原-transmethalide方案。铜烷基络合物将主要用于醛的不对称1，2加成和外消旋环氧化物的烷基化动力学拆分。有了这个奖项，有机和大分子化学计划将支持博士布鲁斯H。位于圣巴巴拉的加州大学化学系的Lipshutz说。 Lipshutz博士将致力于开发能够催化许多化学反应的铜络合物。大多数这些铜催化的碳-氢和碳-碳键形成反应产生手性分子（具有两个不可重叠的镜像），并且仅产生两种可能形式之一（单一对映异构体）。这类反应的发展是当今制药工业面临的最重要的问题之一。这些在铜中具有催化作用的转化可用于精细化学品和药物的大规模生产。在这项工作的过程中培训的学生将获得制药和特种化学品行业所需的技能，现在生产一些单一的对映体化合物。