EAGER: Synthesizing Signal Processing Functions with Biochemical Reactions

EAGER：利用生化反应综合信号处理功能

• 批准号: 0946601
• 负责人: Keshab Parhi
• 金额: $ 20万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0946601&HistoricalAwards=false
• 关键词: EAGER; Synthesizing; Signal; Processing; Functions

This proposal addresses the synthesis of computations and signal processing operations in a novel context: protein-protein biochemistry where the inputs and outputs are quantities of different types of proteins. The project will demonstrate that biochemistry can implement simple and powerful digital signal processing (DSP) operations. Constructs like and decision feedback equalizers will be implemented: given input quantities of proteins, the system performs a decision to deliver a drug or not, adaptively and autonomously. Also band-pass filtering will be implemented: the quantity of output protein is a highly-tuned function of the frequency of the changes in the quantities of input proteins. Other DSP functions such as FFTs will be implemented. The design of such DSP functions will be investigated in an abstract framework, as a proof of concept. (At this time, the research will not attempt to address the experimental application of these ideas in vitro or in vivo). Techniques for analyzing the dynamics of biological systems are well established. However, synthesizing computation with such mechanisms requires new techniques ? and an entirely new mindset. Success in this endeavor will open numerous opportunities in fields such as biochemical sensing and drug delivery. An important goal of the project is to communicate the goals and the impetus for interdisciplinary research to a wide audience. A new graduate-level course will be developed, titled "Circuits, Computation, and Biology" offered jointly through the ECE Department and the new Biomedical Informatics and Computational Biology Program at the University of Minnesota.

这一建议在一个新的背景下解决了计算和信号处理操作的综合：蛋白质-蛋白质生物化学，其中输入和输出是不同类型的蛋白质的数量。该项目将展示生物化学可以实现简单而强大的数字信号处理(DSP)操作。将实施像和决策反馈均衡器这样的结构：给定蛋白质的输入量，系统自适应地和自主地执行是否输送药物的决定。还将实施带通滤波：输出蛋白质的数量是输入蛋白质数量变化频率的高度调谐函数。还将实现FFT等其他数字信号处理功能。作为概念证明，将在抽象框架中研究此类DSP功能的设计。(目前，这项研究不会试图解决这些想法在体外或体内的实验应用)。分析生物系统动力学的技术已经建立得很好了。然而，用这样的机制来综合计算需要新的技术？和一种全新的心态。这一努力的成功将在生化传感和药物输送等领域提供大量机会。该项目的一个重要目标是向广大受众传达跨学科研究的目标和动力。将通过欧洲经委会系和明尼苏达大学新的生物医学信息学和计算生物学项目联合开设一门新的研究生级别的课程，名为“电路、计算和生物学”。