Molecular imaging of the alveolar echinococcosis in small animals

小动物肺泡包虫病的分子影像

• 批准号: 195043480
• 负责人: Dr. Stefan Wiehr
• 金额: --
• 依托单位: Interfakultäres Institut für Biochemie (IFIB)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/195043480?language=en
• 关键词: Molecular; imaging; alveolar; echinococcosis; small

Alveolar echinococcosis (AE) is a life-threatening disease caused by the larval stage (metacestode) of the tapeworm Echinococcus multilocularis and is limited to the northern hemisphere. The E. multilocularis metacestode has a tumor-like, multivascular structure and is able to infiltrate surrounding tissues especially organs such as the liver, kidneys and central nervous system. Pathological changes of the host occur after years or decades after the initial infection, which makes a clear diagnosis of the early infection difficult. However, early diagnosis of AE is crucially needed for efficient management and treatment of the disease. It is still challanging to detect parasites below 10 mm in diameter by non-invasive imaging methods, such as ultra sound, computed tomography and magnetic resonance imaging. Moreover, E. multilocularis cysts below 10 mm in diameter can also be undetectable in serum samples.Molecular imaging has a great potential in the field of infectious diseases to develop new diagnosis and therapy strategies. Basic biological mechanisms of parasites can be investigated by molecular imaging techniques, including the migration of the parasite in its host. New Biomarkers, such as radiolabeled antibodies or antibody fragments which are specific to E. multilocularis are evaluated for early diagnosis as well for monitoring the infection in an animal model. Small animal PET combined with MRI or optical imaging is used to test the specific biomarkers with new radiolabelling procedures and using different chelators and novel isotopes for the diagnosis of AE.

泡状棘球绦虫病(AE)是由多房棘球绦虫幼虫阶段(后鞭虫)引起的一种危及生命的疾病，仅限于北半球。多房棘球绦虫具有肿瘤样的多血管结构，能够渗透到周围组织，特别是肝脏、肾脏和中枢神经系统等器官。宿主的病理变化在初次感染数年或数十年后发生，这使得早期感染的明确诊断变得困难。然而，对于疾病的有效管理和治疗来说，早期诊断AE是至关重要的。用超声、计算机断层扫描和磁共振成像等非侵入性成像方法检测直径在10 mm以下的寄生虫仍是一项具有挑战性的工作。此外，在血清样本中也检测不到直径小于10 mm的多房棘球绦虫。分子成像在传染病领域发展新的诊断和治疗策略具有巨大的潜力。寄生虫的基本生物学机制可以通过分子成像技术来研究，包括寄生虫在宿主中的迁移。新的生物标志物，如针对多房棘球绦虫的放射性标记抗体或抗体片段，也被评估用于早期诊断以及在动物模型中监测感染。小动物PET结合核磁共振或光学成像，通过新的放射性标记程序，使用不同的螯合剂和新的同位素来检测特定的生物标记物，用于诊断AE。

项目成果

Fluorescence and Cerenkov luminescence imaging

• DOI: 10.1055/s-0037-1616471
• 发表时间: 2016
• 期刊: Nuklearmedizin
• 作者: Johannes Schwenck;Kerstin Fuchs;S. Eilenberger;Anna-Maria Rolle;S. C. Vega;Wolfgang M. Thaiss;Florian Maier

New pathogen-specific immunoPET/MR tracer for molecular imaging of a systemic bacterial infection

• DOI: 10.18632/oncotarget.7770
• 发表时间: 2016-03-08
• 期刊: ONCOTARGET
• 作者: Wiehr, Stefan;Warnke, Philipp;Autenrieth, Stella E.
• 通讯作者: Autenrieth, Stella E.

Preclinical and Translational PET/MR Imaging

临床前和转化 PET/MR 成像

• DOI: 10.2967/jnumed.113.129221
• 发表时间: 2014
• 期刊: The Journal of Nuclear Medicine
• 作者: S. Wiehr;M. R. Divine;S. Gatidis;G. T. Gullberg;F. C. Maier;A. M. Rolle;J. Schwenck;W. M. Thaiss;B. J. Pichler
• 通讯作者: B. J. Pichler

Evaluation of the Metabolic Activity of Echinococcus multilocularis in Rodents Using Positron Emission Tomography Tracers

• DOI: 10.1007/s11307-014-0815-3
• 发表时间: 2015-08-01
• 期刊: MOLECULAR IMAGING AND BIOLOGY
• 影响因子: 3.1
• 作者: Rolle, Anna-Maria;Soboslay, Peter T.;Wiehr, Stefan
• 通讯作者: Wiehr, Stefan

ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo

• DOI: 10.1073/pnas.1518836113
• 发表时间: 2016-02-23
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Rolle, Anna-Maria;Hasenberg, Mike;Wiehr, Stefan
• 通讯作者: Wiehr, Stefan