(CAREER) Real-Time Detection, Monitoring and Characterization of Single Nanoparticle/Bioaerosol Using On-Chip Resonators

（职业）使用片上谐振器对单个纳米颗粒/生物气溶胶进行实时检测、监测和表征

• 批准号: 0954941
• 负责人: Lan Yang
• 金额: $ 40万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0954941&HistoricalAwards=false
• 关键词: CAREER; Real; Time; Detection; Monitoring

Objective: The research objective of this project is to explore and develop a new label free optical technique to achieve portable, inexpensive and high resolution devices capable of real time, in situ detection of particles to address issues faced by conventional particle counters/spectrometers. Specifically, we will investigate and exploit mode splitting in ultra high quality Whispering Gallery Mode optical resonators for ultrasensitive, realtime, insitu monitoring and characterization of nanoparticles with various chemical and physical properties at single particle resolution.Intellectual Merit: Real time, in situ single particle detection and characterization will lay the groundwork to investigate the dynamics and properties of individual nanoparticles and effectively utilize them to develop innovative products. However, most conventional macroscale methods only allow ensemble measurement of nanoparticles, revealing average behaviors of the nanoparticle systems. Our chip scale microscopic sensing device provides label free, single particle resolution, self referencing feature, and superior noise immunity for real time, in situ measurements at ambient conditions, which constitutes a significant advancement compared to existing schemes.Broader Impact: The interdisciplinary nature of this work encourages collaborations with groups in environmental engineering, biology and physics to explore new classes of spectroscopy for characterizing the interactions between particles, molecules, and ligands. The success of this project will have significant impacts on materials science, chemical analysis, energy, biomedicine, communication, instrumentation, and metrology for nanotechnology. The PI will develop education programs in which students at different levels can obtain broad knowledge and diverse technical skills in nanoscience and technology. She will leverage the existing outreach programs between Washington University and surrounding communities to foster and promote understanding of nanotechnology among the general public.

目的：本项目的研究目标是探索和开发一种新的无标记光学技术，以实现便携式、廉价和高分辨率的实时、原位检测颗粒的设备，以解决传统颗粒计数器/光谱仪所面临的问题。具体地说，我们将研究和利用超高质量语廊模式光学谐振器中的模式分裂，以在单粒子分辨率下对具有各种化学和物理性质的纳米粒子进行超灵敏、实时、在线监测和表征。智能优势：实时、原位单粒子检测和表征将为研究单个纳米粒子的动力学和性质并有效利用它们开发创新产品奠定基础。然而，大多数传统的宏观方法只允许对纳米颗粒进行整体测量，揭示了纳米颗粒系统的平均行为。我们的芯片规模显微传感设备提供无标签、单粒子分辨率、自参考功能和卓越的噪声免疫力，可在环境条件下进行实时、现场测量，这与现有方案相比是一个重大进步。广泛影响：这项工作的跨学科性质鼓励与环境工程、生物和物理小组合作，探索新的光谱学类别，以表征粒子、分子和配体之间的相互作用。该项目的成功将对纳米技术的材料科学、化学分析、能源、生物医学、通信、仪器和计量学产生重大影响。国际和平研究所将制定教育计划，让不同水平的学生在纳米科学和技术方面获得广泛的知识和不同的技术技能。她将利用华盛顿大学和周围社区之间现有的外联计划，促进和促进普通公众对纳米技术的理解。