(IRES) International Research Experience for Students: Duke - Aarhus DNA NanoTech Collaboration

这项国际学生研究体验（IRES）活动将北卡罗来纳州的杜克大学和丹麦的奥胡斯大学的专家纳米研究小组联系起来，为来自两国的参与学生和初级研究人员提供为期三年的跨学科指导，学术教育和研究性学习计划。 主要研究者（PI），托马斯H. LaBean和来自杜克的同事将与由Kurt V. Gothelf领导的丹麦合作伙伴合作，在复杂的DNA纳米结构和DNA引导的化学之间的界面上管理一种平衡的、基于团队的研究培训方法。 这是建立在教育和研究合作计划的基础上的，该计划的特点是将领先的奥胡斯共轭化学与杜克团队结合起来，将不同的化合物偶联到化合物上。在复杂纳米结构的设计和实施方面的专业知识。 总的来说，研究工作承诺在分子工程与分子和纳米电子学，纳米化学，生物传感器，或其他生物医学领域的潜在应用显着成果。接触两个领先机构的富有成效的合作研究，并参与他们的导师？尖端研究 杜克-奥胡斯IRES模式涉及博士后导师和多样化的研究准备就绪的高中生以及美国研究生和本科生。私家侦探？在美国化学学会的支持下，参与SEED项目有助于识别合适的高中生。为了平衡和加强互动，该计划还聘请丹麦初级研究人员，由丹麦国家研究基金会独立支持。每个初级参与者都将被分配到旨在促进整个项目研究目标的项目。通过有计划的跨学科合作，他们将获得合成化学，DNA结构工程，蛋白质生物化学，材料科学和分子生物学技术的知识。丹麦IRES在分子工程方面的合作实现了培养全球科学家和工程师的计划目标，使美国和欧洲的专家能够联合收割机互补人才，并在共同感兴趣和能力强的领域分享研究和教育资源。 更广泛的影响包括美国初级研究人员和学生通过参与前沿研究，甚至最近的教科书也没有解决它，并通过接触两个杰出机构的集体研究生活，向国际领导人介绍纳米技术。 如果成功，结果将继续提高我们使用DNA自组装来组织纳米材料和编程复杂纳米化学的能力。学生？早期的职业经验预计将增加他们在未来建立国际合作的可能性。

This International Research Experience for Students (IRES) activity links expert nano research groups at Duke University in North Carolina and the University of Aarhus in Denmark for a three-year program of interdisciplinary mentoring, academic education, and research-based learning for participating students and junior researchers from both countries. Principal Investigator (PI), Thomas H. LaBean, and colleagues from Duke will work with Danish partners, led by Kurt V. Gothelf, to manage a balanced, team-based approach for research training at the interface between complex DNA nanostructures and DNA-guided chemistry. This builds on a program of cooperation in education and research that features the melding of leading Aarhus conjugation chemistry for coupling diverse compounds to oligonucleotieds with the Duke team?s expertise in design and implementation of complex nanostructures. Overall, research efforts promise significant outcomes in molecular engineering with potential applications in molecular and nano-electronics, nanochemistry, biosensors, or other biomedical areas.The educational value of the IRES rests with the students? exposure to the productive, cooperative research of the two leading institutions and involvement in their mentors? cutting-edge research. The Duke-Aarhus IRES model involves post-doctoral mentors and diverse, research-ready high school students as well as U.S. graduate and undergraduate students. The PI?s participation in Project SEED, supported by the American Chemical Society, assists with identification of appropriate high school students. For balance and heightened interaction, the program also engages junior Danish researchers, supported independently by the Danish National Research Foundation. Each of the junior participants will be assigned projects that are designed to contribute to program-wide research goals. Through planned cross-disciplinary teamwork, they will acquire knowledge of techniques in synthetic chemistry, DNA structural engineering, protein biochemistry, materials science, and molecular biology.This U.S.-Danish IRES collaboration in molecular engineering fulfills the program objective of developing global scientists and engineers by enabling experts in the United States and Europe to combine complementary talents and share research and education resources in an area of strong mutual interest and competence. Broader impacts include the introduction of U.S. junior researchers and students to international leaders in nanotechnology through involvement in cutting-edge research so new that even recent textbooks do not address it and through exposure to the collective research life of two outstanding institutions. If successful, results will continue to improve our ability to use DNA self-assembly to organize nanomaterials and to program sophisticated nanochemistry. The students? early career experiences are expected to increase the probability of their establishing international collaborations in the future.