(IRES) International Research Experience for Students: North Carolina State - Aarhus DNA NanoTech Collaboration

这项面向学生的国际研究体验（IRES）活动将北卡罗来纳州立大学和丹麦奥胡斯大学的专家纳米研究小组联系起来，为两国参与的学生和初级研究人员提供跨学科指导、学术教育和研究性学习项目。首席研究员Thomas H. LaBean和美国同事将与由Kurt V. Gothelf领导的丹麦伙伴合作，在复杂DNA纳米结构和DNA引导化学之间的界面上管理一种平衡的、基于团队的研究训练方法。这是建立在教育和研究合作项目的基础上的，该项目的特点是将领先的奥胡斯偶联化学技术与美国团队在复杂纳米结构的设计和实施方面的专业知识结合起来，将各种化合物偶联到寡核核苷酸上。总的来说，研究工作承诺在分子工程方面取得重大成果，并在分子和纳米电子学、纳米化学、生物传感器或其他生物医学领域具有潜在的应用。IRES的教育价值在于学生能够接触到两所领先机构的富有成效的合作研究，并参与到他们导师的前沿研究中。美国和丹麦的IRES模式涉及博士后导师和多样化的、准备进行研究的高中生以及美国研究生和本科生。PI参与了由美国化学会支持的SEED项目，帮助识别合适的高中学生。为了平衡和加强互动，该项目还聘请了由丹麦国家研究基金会独立支持的初级丹麦研究人员。每个初级参与者都将被分配项目，这些项目旨在为整个项目的研究目标做出贡献。通过有计划的跨学科团队合作，他们将获得合成化学、DNA结构工程、蛋白质生物化学、材料科学和分子生物学等方面的技术知识。美国和丹麦在分子工程方面的IRES活动实现了培养全球科学家和工程师的计划目标，使美国和欧洲的专家能够结合互补的人才，并在共同感兴趣和有能力的领域分享研究和教育资源。更广泛的影响包括通过参与尖端研究，将美国初级研究人员和学生介绍给纳米技术领域的国际领导者。如果成功，结果将继续提高我们使用DNA自组装来组织纳米材料和编程复杂纳米化学的能力。学生们早期的职业经历有望增加他们未来建立国际合作的可能性。

This International Research Experience for Students (IRES) activity links expert nano research groups at North Carolina State University and the University of Aarhus in Denmark for a program of interdisciplinary mentoring, academic education, and research-based learning for participating students and junior researchers from both countries. Principal Investigator (PI), Thomas H. LaBean, and U.S. colleagues will work with Danish partners, led by Kurt V. Gothelf, to manage a balanced, team-based approach for research training at the interface between complex DNA nanostructures and DNA-guided chemistry. This builds on a program of cooperation in education and research that features the melding of leading Aarhus conjugation chemistry for coupling diverse compounds to oligonucleotieds with the U.S. team's expertise in design and implementation of complex nanostructures. Overall, research efforts promise significant outcomes in molecular engineering with potential applications in molecular and nano-electronics, nanochemistry, biosensors, or other biomedical areas.The educational value of the IRES rests with the students' exposure to the productive, cooperative research of the two leading institutions and involvement in their mentors' cutting-edge research. The U.S.-Danish IRES model involves post-doctoral mentors and diverse, research-ready high school students as well as U.S. graduate and undergraduate students. The PI's participation in Project SEED, supported by the American Chemical Society, assists with identification of appropriate high school students. For balance and heightened interaction, the program also engages junior Danish researchers, supported independently by the Danish National Research Foundation. Each of the junior participants will be assigned projects that are designed to contribute to program-wide research goals. Through planned cross-disciplinary teamwork, they will acquire knowledge of techniques in synthetic chemistry, DNA structural engineering, protein biochemistry, materials science, and molecular biology.This U.S.-Danish IRES activity in molecular engineering fulfills the program objective of developing global scientists and engineers by enabling experts in the United States and Europe to combine complementary talents and share research and education resources in an area of strong mutual interest and competence. Broader impacts include the introduction of U.S. junior researchers and students to international leaders in nanotechnology through involvement in cutting-edge research. If successful, results will continue to improve our ability to use DNA self-assembly to organize nanomaterials and to program sophisticated nanochemistry. The students' early career experiences are expected to increase the probability of their establishing international collaborations in the future.