(IRES) International Research Experience for Students: North Carolina State - Aarhus DNA NanoTech Collaboration

这项面向学生的国际研究体验(IRES)活动将北卡罗来纳州立大学和丹麦奥胡斯大学的专家纳米研究小组联系在一起，为两国参与的学生和初级研究人员提供跨学科指导、学术教育和基于研究的学习计划。首席研究员托马斯·H·拉宾及其美国同事将与库尔特·V·戈瑟夫领导的丹麦合作伙伴合作，在复杂的DNA纳米结构和DNA引导的化学之间的界面上管理一种平衡的、基于团队的研究培训方法。这是建立在教育和研究合作计划的基础上的，该计划将领先的奥胡斯共轭化学将不同化合物偶联成寡核苷酸与美国团队在复杂纳米结构设计和实施方面的专业知识融合在一起。总体而言，研究工作有望在分子工程方面取得重大成果，在分子和纳米电子学、纳米化学、生物传感器或其他生物医学领域具有潜在应用。IRES的教育价值在于学生接触到两个领先机构的富有成效的合作研究，并参与他们导师的前沿研究。美国-丹麦IRES模式包括博士后导师和多样化的、准备进行研究的高中生，以及美国研究生和本科生。在美国化学学会的支持下，国际学生联合会参与了SEED项目，帮助确定合适的高中生。为了平衡和加强互动，该项目还聘请了丹麦初级研究人员，由丹麦国家研究基金会独立支持。每个初级参与者都将被分配到旨在为整个项目的研究目标做出贡献的项目。通过计划的跨学科团队合作，他们将获得合成化学、DNA结构工程、蛋白质生物化学、材料科学和分子生物学方面的技术知识。这项美国-丹麦IRES分子工程活动通过使美国和欧洲的专家能够在共同感兴趣和能力很强的领域结合互补的人才并共享研究和教育资源，实现了培养全球科学家和工程师的计划目标。更广泛的影响包括通过参与尖端研究将美国初级研究人员和学生介绍给纳米技术的国际领导者。如果成功，结果将继续提高我们使用DNA自组装来组织纳米材料和编程复杂纳米化学的能力。学生的早期职业经历预计将增加他们未来建立国际合作的可能性。

This International Research Experience for Students (IRES) activity links expert nano research groups at North Carolina State University and the University of Aarhus in Denmark for a program of interdisciplinary mentoring, academic education, and research-based learning for participating students and junior researchers from both countries. Principal Investigator (PI), Thomas H. LaBean, and U.S. colleagues will work with Danish partners, led by Kurt V. Gothelf, to manage a balanced, team-based approach for research training at the interface between complex DNA nanostructures and DNA-guided chemistry. This builds on a program of cooperation in education and research that features the melding of leading Aarhus conjugation chemistry for coupling diverse compounds to oligonucleotieds with the U.S. team's expertise in design and implementation of complex nanostructures. Overall, research efforts promise significant outcomes in molecular engineering with potential applications in molecular and nano-electronics, nanochemistry, biosensors, or other biomedical areas.The educational value of the IRES rests with the students' exposure to the productive, cooperative research of the two leading institutions and involvement in their mentors' cutting-edge research. The U.S.-Danish IRES model involves post-doctoral mentors and diverse, research-ready high school students as well as U.S. graduate and undergraduate students. The PI's participation in Project SEED, supported by the American Chemical Society, assists with identification of appropriate high school students. For balance and heightened interaction, the program also engages junior Danish researchers, supported independently by the Danish National Research Foundation. Each of the junior participants will be assigned projects that are designed to contribute to program-wide research goals. Through planned cross-disciplinary teamwork, they will acquire knowledge of techniques in synthetic chemistry, DNA structural engineering, protein biochemistry, materials science, and molecular biology.This U.S.-Danish IRES activity in molecular engineering fulfills the program objective of developing global scientists and engineers by enabling experts in the United States and Europe to combine complementary talents and share research and education resources in an area of strong mutual interest and competence. Broader impacts include the introduction of U.S. junior researchers and students to international leaders in nanotechnology through involvement in cutting-edge research. If successful, results will continue to improve our ability to use DNA self-assembly to organize nanomaterials and to program sophisticated nanochemistry. The students' early career experiences are expected to increase the probability of their establishing international collaborations in the future.