MEMS-based Polarization-Sensitive and Doppler Optical Coherence Tomography for In Vivo Diagnosis and Imaging-Guided Surgery

ECCS-1002209：基于MEMS的偏振敏感和多普勒光学相干层析成像用于体内诊断和成像引导手术本研究的目的是开发一种配备微型成像探头的无损光学成像系统，可用于关节镜下对各种关节疾病和损伤的诊断和干预。该方法是通过将独特的高填充系数两轴MEMS反射镜设计与不需要与MEMS芯片进行引线键合的新型封装技术相结合，实现成像探头的小型化。智能优势：所提出的光学成像系统基于傅立叶域光学相干层析成像，具有偏振敏感和多普勒速度测量能力。将实时测量半月板的血流速度。因此，该系统不仅可以对关节组织(如关节软骨、半月板等)进行活体三维成像，而且还可以同时实现高成像速度、高空间分辨率和高对比度。广泛影响：通过简单地修改包装，所提出的微型成像探针的成功可以立即应用于各种癌症的早期诊断，包括胃肠道、膀胱癌和前列腺癌。超小探头封装技术还可以实现基于MEMS镜片的血管内成像，用于诊断和干预心脏病。拟议的成像探头携带方便，价格低廉，使更多的人能够获得医疗保健，并拥有更健康的生活。这种低成本的探头可以制成一次性探头，从而将疾病传播的风险降至最低。计划开展活动，增加工科招生，促进少数民族学生参加工科，并扩大到当地初中生和高中生。科学发现和技术进步将通过在线、会议和期刊出版物传播。

ECCS-1002209: MEMS-based Polarization-Sensitive and Doppler Optical Coherence Tomography for In Vivo Diagnosis and Imaging-Guided SurgeryThe objective this research is to develop a nondestructive optical imaging system equipped with a miniature imaging probe that can be used for arthroscopic diagnosis and intervention of various articular joint diseases and injuries. The approach is to miniaturize the imaging probe by integrating a unique high-fill-factor two-axis MEMS mirror design with a novel packaging technique that requires no wire bonding to MEMS chips. Intellectual Merits: The proposed optical imaging system is based on Fourier domain optical coherence tomography with polarization-sensitive and Doppler velocity measurement capabilities. Blood flow rate of menisci will be measured in real time. Thereby the proposed system can not only perform in vivo three-dimensional imaging of articular tissues (e.g. articular cartilage, meniscus, etc), but it can also simultaneously achieve high imaging speed, high spatial resolution and high contrast.Broader Impacts: The success of the proposed miniature imaging probes can be immediately applied to early diagnosis of various cancers including gastrointestinal, bladder and prostate cancers by simply modifying the packaging. The ultra-small probe packaging technique may also enable MEMS mirror-based intravascular imaging for diagnosing and intervening heart diseases. The proposed imaging probes are portable and inexpensive, allowing more people to access medical care and have healthier life. The low-cost probes can be made disposable, which minimizes the risk of disease transmission. Activities are planned to increase engineering enrollment, promote minority students to attend engineering, and outreach to local middle-school and high-school students. The scientific discoveries and technical advancements will be disseminated via online, conference and journal publications.