EAGER: Designer nanostructures in protection of cells under harsh environment

EAGER：设计纳米结构在恶劣环境下保护细胞

• 批准号: 1007495
• 负责人: Sudipta Seal
• 金额: $ 6万
• 依托单位: The University of Central Florida Board of Trustees
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1007495&HistoricalAwards=false
• 关键词: EAGER; Designer; nanostructures; protection; cells

This research focuses on the science behind developing nano rare earth particles and their role in the protection of cells under radiation environments. Potential payoffs include (1) engineering of nanoparticle surfaces for biomedical applications, (2) understanding and simulating the interaction of nanoparticles under harsh radiation atmospheres and (3) the use of nanoparticles in the prevention of radiation induced damage. The work tests the hypothesis that cerium oxide nanoparticles (CNPs) protect gastrointestinal mucosa from radiation therapy (RT) without protecting the tumor. This will be a major breakthrough in cancer treatment if it is successful. Project scope includes the synthesis and characterization of bare and polymer coated CNPs, numerical modeling of the nanoparticle-cell relationship to study the prevention of radiation damage by nanoceria, and determining the effect of CNPs on irradiated gastrointestinal mucosa and tumor in vitro. Broader impacts of the work are focused on biomedical applications and potential applications of nanotechnology to cancer treatment. The research will be integrated into various courses taught at the University. Both undergraduate and graduate students will be trained in this project.

这项研究的重点是开发纳米稀土颗粒背后的科学及其在辐射环境下保护细胞中的作用。潜在的回报包括（1）用于生物医学应用的纳米颗粒表面工程，（2）理解和模拟恶劣辐射环境下纳米颗粒的相互作用，以及（3）使用纳米颗粒预防辐射引起的损伤。 这项工作检验了氧化铈纳米粒子（CNP）可以保护胃肠粘膜免受放射治疗（RT）的影响而不保护肿瘤的假设。 如果成功的话，这将是癌症治疗的重大突破。 项目范围包括裸露和聚合物涂覆的 CNP 的合成和表征、纳米颗粒与细胞关系的数值模拟以研究纳米陶瓷预防辐射损伤的作用，以及确定 CNP 对受辐射胃肠道粘膜和肿瘤的体外影响。 这项工作的更广泛影响集中在生物医学应用以及纳米技术在癌症治疗中的潜在应用。 该研究将被纳入大学教授的各种课程中。本科生和研究生都将在该项目中接受培训。