International Collaboration in Chemistry: Polymer Supported Lanthanide-BINOLate-Based Catalysts

国际化学合作：聚合物支持的镧系元素-联醇盐基催化剂

• 批准号: 1026553
• 负责人: Patrick Walsh
• 金额: $ 45万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1026553&HistoricalAwards=false
• 关键词: International; Collaboration; Chemistry; Polymer; Supported

In this International Collaboration in Chemistry (ICC) project funded by the Office of International Science and Engineering and the Chemical Catalysis Program of the Chemistry Division, Patrick J. Walsh and Eric J. Schelter, University of Pennsylvania, and Miquel A. Pericàs, Institute of Chemical Research of Catalonia (ICIQ), will link enantioselective lanthanide-based catalysts to solid supports, and enable their facile handling and recycling. Heterobimetallic lanthanide(BINOlate) complexes will be tethered to solid supports through diamine-containing polymers that will tightly bind to their lithium ions, resulting in solid state catalysts which can be used in asymmetric reactions with equal or better performance than their parent compounds. The supported catalysts will also be investigated in batch and flow reactors. Graduate and postdoctoral researchers will participate in exchanges between the Walsh and Schelter labs (U.S.) and the Pericàs group (Spain). These students will learn new techniques that are currently unavailable in their home institutions. If successful, this work is expected to have far reaching implications in organic chemistry, polymer chemistry, and industrial and medicinal synthesis. This novel approach to design may lead to new solid catalysts that are able to perform key enantioselective transformations and then be easily separated from the reaction products (recovered) and reused in multiple applications. The development of flow systems is especially attractive as it provides evidence for the value-added nature of the assembled team in achieving practical, user-ready systems. The MICINN will provide support funds for the Spanish investigators while the NSF will support the U.S. team's efforts.

在这个由国际科学与工程办公室和化学部化学催化计划资助的国际化学合作(ICC)项目中，宾夕法尼亚大学的帕特里克·沃尔什和埃里克·J·舍尔特，以及加泰罗尼亚化学研究所的米克尔·A·佩里卡·S将把对映体选择性的稀土催化剂连接到固体载体上，并使其易于操作和回收。双金属稀土(BINOate)配合物将通过含二胺的聚合物与其锂离子紧密结合在固体载体上，从而产生可用于不对称反应的固态催化剂，其性能与其母体化合物相同或更好。负载型催化剂还将在间歇和流动反应器中进行研究。研究生和博士后研究人员将参加沃尔什和谢尔特实验室(美国)之间的交流。佩里卡·S组合(西班牙)。这些学生将学习目前在本国机构无法获得的新技术。如果成功，这项工作有望在有机化学、聚合物化学以及工业和药物合成方面产生深远的影响。这种新颖的设计方法可能导致新的固体催化剂，这些催化剂能够进行关键的对映选择性转化，然后很容易从反应产物中分离出来(回收)，并在多种应用中重复使用。Flow系统的开发特别有吸引力，因为它证明了组装的团队在实现实用的、用户就绪的系统方面的增值性质。MICINN将为西班牙调查人员提供支持资金，而NSF将支持美国团队的努力。