Novel Tandem Reactions

新颖的串联反应

• 批准号: 0848467
• 负责人: Patrick Walsh
• 金额: $ 45万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848467&HistoricalAwards=false
• 关键词: Novel; Tandem; Reactions

This project will continue work on the development of methods for the formation of C-C bonds using organozinc reagents, as the formation of C-C bonds is of fundamental importance in organic synthesis. New and efficient methods will be studied for the direct conversion of aldehydes into enals, which are among the most important starting materials for organocatalytic reactions. Methods for the stereospecific synthesis of enantioenriched enamines will also be explored. Finally, new classes of enantioenriched cyclopropanes will be prepared through novel halocyclopropanations. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Patrick J. Walsh of the Department of Chemistry at the University of Pennsylvania. Professor Walsh's research efforts involve the development of novel and practical methods for the formation of C-C bonds. Such chemistry will allow multiple reactions to be performed without isolation or purification of intermediates, thus reducing the environmental impact of chemical synthesis. Successful development of these methods will positively impact organic synthesis in the pharmaceutical and agricultural industries.

该项目将继续致力于开发使用有氧蛋白试剂形成C-C键的方法，因为C-C键的形成在有机合成中至关重要。 将研究新的和有效的方法，以直接转化为醛，这是有机催化反应的最重要的起始材料之一。 还将探讨鉴定元素磁带的立体特异性合成方法。 最后，将通过新型的淡烯丙型植物来制备新的对照环丙烷的新类别。通过该奖项，有机和大分子化学计划正在支持宾夕法尼亚大学化学系的帕特里克·J·沃尔什教授的研究。 沃尔什教授的研究工作涉及开发用于形成C-C键的新颖和实用方法。 这种化学将允许在不分解或纯化中间体的情况下进行多种反应，从而减少化学合成的环境影响。 这些方法的成功开发将对药物和农业行业的有机综合产生积极影响。