Synthesis of Chiral Building Blocks
手性构件的合成
基本信息
- 批准号:0315913
- 负责人:
- 金额:$ 45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-07-01 至 2006-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The first objective of this research is to optimize and expand the scope of the asymmetric vinylation of aldehydes to furnish secondary allylic alcohols with high enantioselectivity. The second objective is to use the resulting chiral allylic alcohols in the synthesis of densely functionalized chiral building blocks. Using a single reaction vessel, tandem reactions resulting in the formation of multiple C-C bonds and stereocenters will be explored. Elaboration of the allylic alcohols to a variety of useful chiral building blocks including allylic amines, allylic cyclopropanes and allylic epoxides will be examined and the research will develop methods for the preparation of alpha- and beta- amino acids. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Patrick J. Walsh of the Department of Chemistry at the University of Pennsylvania. Dr. Walsh will focus his work on the development of methodologies for the creation of chiral building blocks containing functional groups useful for directing reactivity. Specifically, chiral allylic alcohols will be targeted. The project could have important broader impact on organic synthesis, in particular in the pharmaceutical and agricultural industries. The work provides an excellent venue for the training of both undergraduate and graduate students and Professor Walsh has developed excellent international collaborations with Mexican scientists.
本研究的第一个目标是优化和扩大醛的不对称乙烯化反应,以获得高对映选择性的仲烯丙醇。 第二个目标是使用所得的手性烯丙醇在合成致密官能化的手性结构单元。 使用一个单一的反应容器,串联反应导致多个C-C键和立体中心的形成将进行探索。 将研究烯丙基醇与各种有用的手性结构单元的酯化反应,包括烯丙基胺、烯丙基环丙烷和烯丙基环氧化物,研究将开发制备α-和β-氨基酸的方法。有了这个奖项,有机和高分子化学计划正在支持宾夕法尼亚大学化学系的帕特里克J.沃尔什博士的研究。 沃尔什博士的工作重点将是开发用于创建手性结构单元的方法,这些结构单元含有可用于指导反应性的官能团。 具体而言,手性烯丙醇将成为目标。该项目可能对有机合成产生重要的广泛影响,特别是在制药和农业工业中。 这项工作为本科生和研究生的培训提供了一个很好的场所,沃尔什教授与墨西哥科学家建立了良好的国际合作。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Patrick Walsh其他文献
Modeling Normal and Malignant Hematopoiesis Using Human Pluripotent Stem Cells
使用人类多能干细胞模拟正常和恶性造血
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Patrick Walsh - 通讯作者:
Patrick Walsh
V4-03 TECHNIQUE AND OUTCOMES OF BLADDER NECK INTUSSUSCEPTION DURING ROBOTIC-ASSISTED RADICAL PROSTATECTOMY: A PARALLEL COMPARATIVE TRIAL
- DOI:
10.1016/j.juro.2015.02.715 - 发表时间:
2015-04-01 - 期刊:
- 影响因子:
- 作者:
Aaron Laviana;Hung-Jui Tan;Siwei Xiong;Ryan Chuang;Eric Treat;Patrick Walsh;Jim Hu - 通讯作者:
Jim Hu
A new method for analyzing the effects of joints and stratigraphy on spring locations: a case study from the Sacramento Mountains, south central New Mexico, USA
- DOI:
10.1007/s10040-008-0320-3 - 发表时间:
2008-07-04 - 期刊:
- 影响因子:2.300
- 作者:
Patrick Walsh - 通讯作者:
Patrick Walsh
Internationalization of U.S. Doctorate Education
美国博士教育的国际化
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
J. Bound;S. Turner;Patrick Walsh - 通讯作者:
Patrick Walsh
Differentiation of Human Natural Killer Cells From Pluripotent Stem Cells In a Feeder Free System Amenable to Clinical Translation
在适合临床转化的无饲养系统中从多能干细胞中分化人类自然杀伤细胞
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
D. Knorr;Z. Ni;Melinda K. Hexum;Amanda Gussiaas;Minho Hong;Patrick Walsh;D. Kaufman - 通讯作者:
D. Kaufman
Patrick Walsh的其他文献
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{{ truncateString('Patrick Walsh', 18)}}的其他基金
REU Site: Novel Techniques and Applications in Catalysis Research Development and Molecular Dynamics
REU 网站:催化研究发展和分子动力学的新技术和应用
- 批准号:
2244061 - 财政年份:2023
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
Applications of Chalcogen-based Oxidation State Alternating Organocatalysts
硫族氧化态交替有机催化剂的应用
- 批准号:
2154593 - 财政年份:2022
- 资助金额:
$ 45万 - 项目类别:
Continuing Grant
Deprotonative carbonylation cross-couplings
去质子羰基化交叉偶联
- 批准号:
1902509 - 财政年份:2019
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
REU Site: Novel Techniques and Applications in Catalysis Research Development and Molecular Dynamics
REU 网站:催化研究发展和分子动力学的新技术和应用
- 批准号:
1851640 - 财政年份:2019
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
Changing the Paradigm: Chelation Control with Silyloxy and Halo Carbonyl Compounds
改变范式:用甲硅烷氧基和卤代羰基化合物进行螯合控制
- 批准号:
1152488 - 财政年份:2012
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
International Collaboration in Chemistry: Polymer Supported Lanthanide-BINOLate-Based Catalysts
国际化学合作:聚合物支持的镧系元素-联醇盐基催化剂
- 批准号:
1026553 - 财政年份:2010
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
Acquisition of a High-Throughput DNA Sequencer: A Critical Component of the University of Miami Marine Genomics Initiative
获取高通量 DNA 测序仪:迈阿密大学海洋基因组计划的关键组成部分
- 批准号:
0215667 - 财政年份:2002
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
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