CAREER: Developing an Understanding of Asymmetric Induction:The Use of Inorganic Titanium Bissulfonamido Based Complexesin Asymmetric Catalysis

这个无机、生物无机和有机金属化学项目的教师早期职业发展（Career）奖支持圣地亚哥州立大学化学系Patrick J. Walsh博士对钛催化剂不对称诱导机制的研究。本文将制备几种新的手性双（磺胺）钛配合物，并对其催化烷基与醛的不对称加成的有效性进行了测试。他们希望对反应中的中间体进行建模，从而为活性位点的重要特征和设计更有效的催化剂提供指导。除了让本科生参与这项研究外，沃尔什博士还将开展一项广泛的推广计划，以丰富圣地亚哥-墨西哥北部地区的化学教育。选择性合成具有特定对称性的化合物，即右旋或左旋化合物，是一个重要的化学目标。这种类型的方法对制药工业和许多生物学研究至关重要。在这项研究中，选择性合成发生的方式将得到更详细的了解。本科生将参与这个问题导向的研究。此外，将与提华纳理工学院合作，为美国和墨西哥学生开展科学推广项目。

This Faculty Early Career Development (CAREER) award in the Inorganic, Bioinorganic, and Organometallic Chemistry program supports research by Dr. Patrick J. Walsh, Chemistry Department, San Diego State University, on the mechanism of asymmetric induction by titanium catalysts. Several new chiral titanium bis(sulfonamido) complexes will be prepared and tested for their effectiveness in the catalytic asymmetric addition of alkyl groups to aldehydes. They are expected to model the intermediates in this reaction and so to provide guidance about important features of the active site and about design of more effective catalysts. In addition to involving undergraduate students in this research, Dr. Walsh will conduct an extensive outreach program to enrich chemistry education in the San Diego-northern Mexico region. Selective synthesis of compounds with a specific symmetry, that is, of either a right- or left-handed form, is an important chemical goal. Methods of this type are critical to the pharmaceutical industry and to many biological studies. In this research, a more detailed knowledge of the way in which selective synthesis occurs will be achieved. Undergraduates will be involved in this problem-directed research. In addition, outreach programs in science in collaboration with the Instituto Tecnologico de Tijuana for US and Mexican students will be undertaken.