Design of New Helical Metal Ligand Systems for Asymmetric Catalysis

9418360 Walsh这项授予圣地亚哥州立大学的启动基金将支持Patrick Walsh教授的研究。研究的目的是开发新的手性金属配合物及其作为有机合成催化剂的应用。具体而言，将制备基于磺胺取代手性二胺的配体，当与IV族金属结合时形成四面体螺旋配合物。这些强酸性配合物将作为Diels-Alder反应、Claisen重排和醛缩反应中碳-碳键形成活性的催化剂进行测试。对不对称催化和分子识别的研究将导致手性路易斯酸催化的进展。新的配体配合物具有多用途，在有机合成中具有广泛的应用前景。

9418360 Walsh This starter grant award to San Diego State University will support the research of Professor Patrick Walsh. The goal of the research is the development of new chiral metal complexes and their application as catalysts for organic synthesis. Specifically, ligands based on sulfonamide-substituted chiral diamines will be prepared which will form tetrahedral helical complexes when combined with Group IV metals. These strongly acidic complexes will be tested as catalyts for carbon-carbon bond formation activity in the Diels-Alder reaction, the Claisen rearrangement and aldol condensations. This study of asymmetric catalysis and molecular recognition will lead to advances in chiral Lewis acid catalysis. The new ligand complexes will be versatile and will be of general use in organic synthesis.