Novel coupling reactions

新颖的偶联反应

• 批准号: 1464744
• 负责人: Patrick Walsh
• 金额: $ 64万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464744&HistoricalAwards=false
• 关键词: Novel; coupling; reactions

In this project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Patrick J. Walsh at the University of Pennsylvania is developing new reactions that form bonds between two carbon atoms and between a carbon atom and a sulfur atom. Bonds between these elements are found in pharmaceutical compounds, agricultural products, and polymers, and therefore, the proposed research has the potential to impact their corresponding scientific and technological areas. The overarching goal is to develop new catalysts and catalytic processes that are both synthetically useful and practical. Professor Walsh is also studying the reaction mechanisms (i.e., how the reactions work) and the factors that control the chemistry of the catalytic reactions, which will help to optimize the outcomes of the catalysis and to add to our fundamental knowledge base about chemistry. Prof. Walsh is specifically addressing the following catalytic transformations: 1) The arylation of sulfenate anions and the enantioselective synthesis of diarylsulfoxides, which are found in a number of commercialized medications, 2) the development of methods to prepare sulfoximines, including in enantioenriched form, and 3) the introduction of a new class of organocatalysts, sulfenate anions, which have potential applications in a number of C-C bond forming reactions. The broader impacts of this research are in the following areas: 1) The new concepts and synthetic methods introduced herein are expected to have a positive impact on society as they may find application in the preparation of intermediates, medications, agricultural products, or materials in academics or industry, 2) Undergraduate students are gaining experience in chemical research, 3) The PI lectures for high school students about this NSF-supported research 4) The PI disseminates the findings of these investigations by publication and seminars at universities and conferences, and 5) The PI continues an international scientific collaboration outreach program with Mexican scientists.

在化学部化学催化计划资助的该项目中，宾夕法尼亚大学的帕特里克·J·沃尔什教授正在开发新的反应，这些反应在两个碳原子之间形成键，在碳原子和硫原子之间形成键。 这些元素之间的键在药品化合物，农产品和聚合物中发现，因此，拟议的研究有可能影响其相应的科学和技术领域。 总体目标是开发新的催化剂和催化过程，这些过程在合成方面有用且实用。 沃尔什教授还正在研究反应机制（即反应的工作原理）和控制催化反应化学的因素，这将有助于优化催化的结果并增加我们对化学的基本知识基础。沃尔什（Walsh）教授正专门解决以下催化转化：1）硫酸阴离子的芳基化和对映选择性的二元硫氧化物的合成，这些合成在许多商业化的药物中被发现，2）在甲氧胺中制备硫酸含量的硫酸含量，以及新的持续形式的硫酸含量，以及3）的新方法，以及新的硫酸含量，以及3）的含有新的持续形式，3）供应量的持续性。在许多C-C键形成反应中。 这项研究的更广泛影响在以下领域：1）预计本文介绍的新概念和合成方法将对社会产生积极影响，因为他们可能会在准备中间体，药物，农产品或材料中的应用中找到应用，或在学者或行业中的材料，2）在化学研究中获得研究，3）在化学研究中获得4）。通过大学和会议的出版物和研讨会，传播了这些调查的发现，5）PI继续与墨西哥科学家进行了国际科学合作宣传计划。