CPS: Small: Collaborative Research: Tumor and Organs at Risk Motion: An Opportunity for Better DMLC IMRT Delivery Systems

本研究的目的是在假设肿瘤和健康器官运动的情况下，开发用于调强放射治疗的治疗规划的算法和软件。目前在放射治疗中解决肿瘤运动的方法是将其视为一个问题，而不是一个治疗机会。然而，在肿瘤和健康器官运动期间，肿瘤可能会更好地暴露于治疗中，从而允许对肿瘤(靶点)进行规定剂量的治疗，同时减少健康器官暴露于辐射。方法是将肿瘤和健康的器官运动视为改善治疗结果的机会，而不是需要克服的障碍。智力价值：这项建议的主要智力价值是为运动优化的强度调制放射疗法开发治疗计划和交付算法，这种疗法利用不同的器官运动来提供超过静态情况的剂量分布。这项工作将表明，与目前最先进的运动管理协议相比，所提出的运动优化的调强放疗治疗计划范例提供了更好的剂量分布。更广泛的影响：该项目的成功完成将标志着调强放射治疗的临床应用迈出了重要的一步，并将有助于提高许多癌症患者的生活质量。这些成果可以整合到现有的设备中，并可用于培训学生和从业人员。剂量累积可视化软件可用于医学生放射治疗计划的培训。

The objective of this research is to develop algorithms and software for treatment planning in intensity modulated radiation therapy under assumption of tumor and healthy organs motion. The current approach to addressing tumor motion in radiation therapy is to treat it as a problem and not as a therapeutic opportunity. However, it is possible that during tumor and healthy organs motion the tumor is better exposed for treatment, allowing for the prescribed dose treatment of the tumor (target) while reducing the exposure of healthy organs to radiation. The approach is to treat tumor and healthy organs motion as an opportunity to improve the treatment outcome, rather than as an obstacle that needs to be overcome. Intellectual Merit: The leading intellectual merit of this proposal is to develop treatment planning and delivery algorithms for motion-optimized intensity modulated radiation therapy that exploit differential organ motion to provide a dose distribution that surpasses the static case. This work will show that the proposed motion-optimized IMRT treatment planning paradigm provides superior dose distributions when compared to current state-of-the art motion management protocols. Broader Impact: Successful completion of the project will mark a major step for clinical applications of intensity modulated radiation therapy and will help to improve the quality of life of many cancer patients. The results could be integrated within existing devices and could be used for training of students and practitioners. The visualization software for dose accumulation could be used to train medical students in radiation therapy treatment planning.