EAGER: Preliminary Study on Novel self-assembled Toroidal-Spiral MicroParticles (TSMPs) for sustained release of therapeutic proteins and peptides: theory and experiments
EAGER:用于持续释放治疗性蛋白质和肽的新型自组装环形螺旋微粒(TSMP)的初步研究:理论和实验
基本信息
- 批准号:1039531
- 负责人:
- 金额:$ 6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-01 至 2012-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The research objective of the proposal is to test the hypothesis that self-assembly by interaction of viscous sedimentation, diffusion, and cross-linking kinetics can produce a new category of polymeric micro-particles with a toroidal-spiral internal structure that offers advantages for sustained drug release. More specifically, during the particle formation, therapeutic proteins and peptides are simultaneously encapsulated into the toroidal-spiral channels. In contrast with prevailing protein delivery methods, toroidal-spiral micro-particles(TSMPs) can be formed and loaded with proteins entirely within the aqueous phase, under benign conditions (room temperature, low shear and low interfacial tensions) that preserve delicate macromolecular conformations and thereby maximize bioactivity and bioavailability. To validate this novel idea, and thereby mitigate conceptual risk for the longer project, we request support for one-year of research to provide more preliminary results for a regular proposal in future. Within the one-year period proposed here, two key aspects will be addressed: (1) protein self-loading into the toroidal-spiral particles, and (2) scaling down toroidal-spiral particles from the millimeter scale (currently achievable) to micron dimensions. On the basis of preliminary experimental and theoretical work, we expect success in both endeavors. The research plan below includes contingency plans in case the initial approach does not work as anticipated. Intellectual Merit. Integrating laboratory investigation with versatile computer simulations, this proposal addresses the fundamental fluid mechanics and mass transfer that enable a new category of polymeric drug-delivery particles for local sustained release of therapeutic proteins and peptides. TSMPs will be generated by light-triggered flash polymerization of intricately wound liquid structures. These liquid structures form by hydrodynamic forces when a water-miscible, polymeric drop sediments at low Reynolds number through an aqueous solution. The initial impact of the polymeric droplets into the aqueous pool (forming bell shapes of vortex rings) for arbitrary viscosity ratio and non-Newtonian rheology represents a largely unexplored regime in fluid mechanics, to which both quantitative visualization experiments and computer modeling will be applied. The anticipated findings will greatly enhance our quantitative understanding of new self-assembly processes, thereby providing a quantum leap in producing microparticles with novel structures. Broader Impacts. This project provides a technological platform that can potentially be translated into medical treatments for many complex diseases. Research will impact the ChE curriculum through a new graduate microfluidics course, two modules for the undergraduate Transport Phenomena sequence and a sequence of undergraduate research projects. A dedicated website (www.microfluidtech.org) will publish a suite of Java-based educational modules designed for college and pre-college students, also to be described in an educational journal article. The highly visual nature of the experiments and theoretical results, as well as the societal relevance of the biomedical applications, represent a natural draw for students being recruited into chemical engineering through ongoing departmental relationships with Chicago land high schools. This project leverages ongoing outreach, recruitment and retention efforts by Liu and Nitsche among women and underrepresented minority students.
该提案的研究目的是检验以下假设:通过粘性沉降、扩散和交联动力学的相互作用进行的自组装可以产生具有环形螺旋内部结构的新型聚合物微粒,该内部结构为药物持续释放提供优势。更具体地,在颗粒形成期间,治疗性蛋白质和肽同时包封到环形螺旋通道中。与流行的蛋白质递送方法相比,环形螺旋微颗粒(TSMP)可以在良性条件(室温、低剪切和低界面张力)下完全在水相中形成并装载蛋白质,所述条件保持精细的大分子构象,从而使生物活性和生物利用度最大化。为了验证这一新颖的想法,从而减轻长期项目的概念风险,我们请求支持为期一年的研究,为未来的定期提案提供更多的初步结果。在这里提出的一年时间内,将解决两个关键方面:(1)蛋白质自加载到环形螺旋颗粒中,以及(2)将环形螺旋颗粒从毫米级(目前可实现)缩小到微米级。在初步的实验和理论工作的基础上,我们期望在这两方面的努力取得成功。下面的研究计划包括应急计划,以防最初的方法不按预期工作。 智力优势。将实验室研究与通用的计算机模拟相结合,该提案解决了基本的流体力学和传质问题,使一类新的聚合物药物递送颗粒能够局部持续释放治疗性蛋白质和肽。TSMP将通过复杂缠绕的液体结构的光触发闪光聚合产生。当水混溶性聚合物液滴在低雷诺数下通过水溶液沉积时,这些液体结构通过水动力形成。对于任意粘度比和非牛顿流变学,聚合物液滴进入水池(形成钟形涡环)的初始影响代表了流体力学中很大程度上未探索的制度,将应用定量可视化实验和计算机建模。预期的发现将大大提高我们对新的自组装过程的定量理解,从而为生产具有新结构的微粒提供了一个量子飞跃。 更广泛的影响。该项目提供了一个技术平台,可以转化为许多复杂疾病的医学治疗。研究将通过一个新的研究生微流体课程,两个模块的本科运输现象序列和本科研究项目的序列影响化学工程课程。一个专门的网站(www.microfluidtech.org)将发布一套为大学和大学预科学生设计的基于Java的教育模块,这些模块也将在教育期刊文章中描述。实验和理论结果的高度可视化性质,以及生物医学应用的社会相关性,代表了通过与芝加哥土地高中正在进行的部门关系被招募到化学工程的学生的自然吸引力。该项目利用了Liu和Nitsche在妇女和代表性不足的少数民族学生中正在进行的外联、招聘和保留工作。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ying Liu其他文献
Polymerization-Driven Self-Wrinkling on a Frozen Hydrogel Surface toward Ultra-Stretchable Polypyrrole-Based Supercapacitors
冷冻水凝胶表面聚合驱动的自皱,用于超可拉伸聚吡咯基超级电容器
- DOI:
10.1021/acsami.2c13829 - 发表时间:
2022 - 期刊:
- 影响因子:9.5
- 作者:
Yufeng Wang;Ying Liu;Zhengtao Wang;Dai Hai Nguyen;Chao Zhang;Tianxi Liu - 通讯作者:
Tianxi Liu
Loop-Mediated Isothermal Amplification (LAMP): Potential Point-of-Care Testing for Vulvovaginal Candidiasis
环介导等温扩增 (LAMP):外阴阴道念珠菌病的潜在护理点测试
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Meng Li;Xiangyu Jin;Qingyun Jiang;Hongbo Wei;Anni Deng;Zeyin Mao;Ying Wang;Zhen Zeng;Yifan Wu;Shuai Liu;Juhyun Kim;Xiaoqian Wang;Ying Liu;Jun Liu;Wenqi Lv;Leyang Huang;Q. Liao;Guoliang Huang;Lei Zhang - 通讯作者:
Lei Zhang
p2 of RSV interacts with OsSGS3 and is a silencing suppressor
RSV 的 p2 与 OsSGS3 相互作用,是一种沉默抑制子
- DOI:
- 发表时间:
- 期刊:
- 影响因子:4.9
- 作者:
Jianguo Jia;Jianguo Wu;Zhao Han;Zhenguo Du;Liuyang Hu;Taiyun Wei;Qiying Lin;Ying Liu;Lianhui Xie;Zujian Wu;Donglai Xiao;Zhengjie Yuan - 通讯作者:
Zhengjie Yuan
Innovation-oriented HRM, TMT reflexivity and organizational change in China: the moderated mediation effect of CEO leader mindfulness
中国创新导向的人力资源管理、TMT反身性与组织变革:CEO领导者正念的调节中介效应
- DOI:
10.1080/13602381.2022.2139058 - 发表时间:
2022-11 - 期刊:
- 影响因子:2.9
- 作者:
Lulu Zhou;Ying Liu;Tianshan Xue;Xiu Zhang - 通讯作者:
Xiu Zhang
Postharvest UV‐C treatment of peach fruit: Changes in transcriptome profile focusing on genes involved in softening and senescence
桃果实采后 UV-C 处理:转录组谱的变化集中于参与软化和衰老的基因
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:2.5
- 作者:
Juan Kan;Yao Hui;Xianpei Lin;Ying Liu;Changhai Jin - 通讯作者:
Changhai Jin
Ying Liu的其他文献
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{{ truncateString('Ying Liu', 18)}}的其他基金
EAGER: Resolving the issue of pairing symmetry in Sr2RuO4
EAGER:解决 Sr2RuO4 中的配对对称性问题
- 批准号:
2312899 - 财政年份:2023
- 资助金额:
$ 6万 - 项目类别:
Standard Grant
ERI: Generative Adversarial Networks for Video Coding
ERI:用于视频编码的生成对抗网络
- 批准号:
2138635 - 财政年份:2022
- 资助金额:
$ 6万 - 项目类别:
Standard Grant
I-CORPS: Scalable Production of Polymeric Nanoparticles Encapsulating Hydrophobic Compounds
I-CORPS:封装疏水性化合物的聚合物纳米颗粒的可规模化生产
- 批准号:
1566113 - 财政年份:2015
- 资助金额:
$ 6万 - 项目类别:
Standard Grant
CAREER: Understanding Nanoprecipitation - Scalable Production of Polymeric Nanoparticles Encapsulating Hydrophobic Compounds
职业:了解纳米沉淀 - 封装疏水性化合物的聚合物纳米颗粒的规模化生产
- 批准号:
1350731 - 财政年份:2014
- 资助金额:
$ 6万 - 项目类别:
Standard Grant
Toroidal-spiral particles (TSPs) for co-delivery of multiple compounds of different sizes
用于共同递送多种不同尺寸化合物的环形螺旋颗粒 (TSP)
- 批准号:
1404884 - 财政年份:2014
- 资助金额:
$ 6万 - 项目类别:
Standard Grant
Materials World Network: Novel Physical Phenomena in Unusual Mesoscopic Superconductors
材料世界网络:异常介观超导体中的新物理现象
- 批准号:
0908700 - 财政年份:2009
- 资助金额:
$ 6万 - 项目类别:
Standard Grant
US-France Cooperative Research: Search for Edge Currents and Domain Walls in SrRu0
美法合作研究:寻找SrRu0中的边缘电流和畴壁
- 批准号:
0340779 - 财政年份:2004
- 资助金额:
$ 6万 - 项目类别:
Standard Grant
Experimental Studies of Nanoscopic Superconductors: Half-flux Quantum, Metallic State of Cooper Pairs, and the Berry's Phase
纳米超导体的实验研究:半通量量子、库珀对金属态和贝里相
- 批准号:
0202534 - 财政年份:2002
- 资助金额:
$ 6万 - 项目类别:
Continuing Grant
Determination of the Exact Symmetry of the Pairing State in Sr2RuO4
Sr2RuO4 中配对态精确对称性的测定
- 批准号:
9974327 - 财政年份:1999
- 资助金额:
$ 6万 - 项目类别:
Continuing Grant
CAREER: Mesoscopic Physics of Disordered Superconductors: An Arena for Research and Education
职业:无序超导体的介观物理:研究和教育的舞台
- 批准号:
9702661 - 财政年份:1997
- 资助金额:
$ 6万 - 项目类别:
Continuing Grant
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