I-CORPS: Scalable Production of Polymeric Nanoparticles Encapsulating Hydrophobic Compounds
I-CORPS:封装疏水性化合物的聚合物纳米颗粒的可规模化生产
基本信息
- 批准号:1566113
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-11-01 至 2017-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The goal of this NSF I-Corps activity is to systematically study technology transition and establish the commercial viability of the technology of scalable production of polymeric nanoparticles encapsulating hydrophobic compounds. One of the greatest advantages of polymeric nanoparticles is that they can carry hydrophobic compounds at much higher concentrations than the solubility of these compounds in aqueous solutions and yet, the encapsulation keeps the compounds from being exposed to physiological conditions until they reach their targets. However, it is challenging to generate large-scale polymeric nanoparticles with well-controlled physical, chemical, and pharmaceutical properties for biomedical applications. The product being proposed is a continuous, scalable process for generating polymeric nanoparticles by integrating flash nanoprecipitation with drying processes. The resulting nanoparticles can have high drug loading, high drug encapsulation efficiency, and narrw particle size distribution.The team will reach the goal of this I-Corps study through assessing product possibilities, potential markets, economics and business models. If successful, the technology of commercial scale production of polymeric nanoparticles with controlled properties will initiate a paradigm shift in the biopharmaceutical industry with realized potential for health benefits for society at large. Low dose and dose frequency, and reduced side effects of the hydrophobic compounds can be achieved by increasing drug bioavailability. Drug compounds demonstrated to have in vitro or ex vivo therapeutic efficacy but undeliverable or difficult to administer can be formulated and available for clinical applications of treating complex diseases. Reproducibly generating nanoparticles with controlled propertied can serve as a platform to study drug pharmacokinetics,functionality, and efficacy.
该NSF I-Corps活动的目标是系统地研究技术过渡,并建立封装疏水化合物的聚合物纳米颗粒的可规模化生产技术的商业可行性。 聚合物纳米颗粒的最大优点之一是,它们可以以比这些化合物在水溶液中的溶解度高得多的浓度携带疏水性化合物,然而,包封使化合物免于暴露于生理条件,直到它们到达它们的目标。然而,它是具有挑战性的,以产生大规模的聚合物纳米粒子具有良好的控制的物理,化学和药物性质的生物医学应用。所提出的产品是一种连续的、可扩展的方法,用于通过将快速纳米沉淀与干燥过程相结合来生成聚合物纳米颗粒。该研究团队将通过评估产品的可能性、潜在市场、经济和商业模式来实现I-Corps研究的目标。如果成功,具有受控性质的聚合物纳米颗粒的商业规模生产技术将引发生物制药行业的范式转变,并为整个社会带来健康益处。疏水性化合物的低剂量和给药频率以及降低的副作用可以通过增加药物生物利用度来实现。被证明具有体外或离体治疗功效但不可递送或难以施用的药物化合物可被配制并可用于治疗复杂疾病的临床应用。具有可控性质的可重复产生的纳米颗粒可以作为研究药物药代动力学、功能和功效的平台。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ying Liu其他文献
Polymerization-Driven Self-Wrinkling on a Frozen Hydrogel Surface toward Ultra-Stretchable Polypyrrole-Based Supercapacitors
冷冻水凝胶表面聚合驱动的自皱,用于超可拉伸聚吡咯基超级电容器
- DOI:
10.1021/acsami.2c13829 - 发表时间:
2022 - 期刊:
- 影响因子:9.5
- 作者:
Yufeng Wang;Ying Liu;Zhengtao Wang;Dai Hai Nguyen;Chao Zhang;Tianxi Liu - 通讯作者:
Tianxi Liu
Loop-Mediated Isothermal Amplification (LAMP): Potential Point-of-Care Testing for Vulvovaginal Candidiasis
环介导等温扩增 (LAMP):外阴阴道念珠菌病的潜在护理点测试
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Meng Li;Xiangyu Jin;Qingyun Jiang;Hongbo Wei;Anni Deng;Zeyin Mao;Ying Wang;Zhen Zeng;Yifan Wu;Shuai Liu;Juhyun Kim;Xiaoqian Wang;Ying Liu;Jun Liu;Wenqi Lv;Leyang Huang;Q. Liao;Guoliang Huang;Lei Zhang - 通讯作者:
Lei Zhang
p2 of RSV interacts with OsSGS3 and is a silencing suppressor
RSV 的 p2 与 OsSGS3 相互作用,是一种沉默抑制子
- DOI:
- 发表时间:
- 期刊:
- 影响因子:4.9
- 作者:
Jianguo Jia;Jianguo Wu;Zhao Han;Zhenguo Du;Liuyang Hu;Taiyun Wei;Qiying Lin;Ying Liu;Lianhui Xie;Zujian Wu;Donglai Xiao;Zhengjie Yuan - 通讯作者:
Zhengjie Yuan
Innovation-oriented HRM, TMT reflexivity and organizational change in China: the moderated mediation effect of CEO leader mindfulness
中国创新导向的人力资源管理、TMT反身性与组织变革:CEO领导者正念的调节中介效应
- DOI:
10.1080/13602381.2022.2139058 - 发表时间:
2022-11 - 期刊:
- 影响因子:2.9
- 作者:
Lulu Zhou;Ying Liu;Tianshan Xue;Xiu Zhang - 通讯作者:
Xiu Zhang
Postharvest UV‐C treatment of peach fruit: Changes in transcriptome profile focusing on genes involved in softening and senescence
桃果实采后 UV-C 处理:转录组谱的变化集中于参与软化和衰老的基因
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:2.5
- 作者:
Juan Kan;Yao Hui;Xianpei Lin;Ying Liu;Changhai Jin - 通讯作者:
Changhai Jin
Ying Liu的其他文献
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{{ truncateString('Ying Liu', 18)}}的其他基金
EAGER: Resolving the issue of pairing symmetry in Sr2RuO4
EAGER:解决 Sr2RuO4 中的配对对称性问题
- 批准号:
2312899 - 财政年份:2023
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
ERI: Generative Adversarial Networks for Video Coding
ERI:用于视频编码的生成对抗网络
- 批准号:
2138635 - 财政年份:2022
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
CAREER: Understanding Nanoprecipitation - Scalable Production of Polymeric Nanoparticles Encapsulating Hydrophobic Compounds
职业:了解纳米沉淀 - 封装疏水性化合物的聚合物纳米颗粒的规模化生产
- 批准号:
1350731 - 财政年份:2014
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Toroidal-spiral particles (TSPs) for co-delivery of multiple compounds of different sizes
用于共同递送多种不同尺寸化合物的环形螺旋颗粒 (TSP)
- 批准号:
1404884 - 财政年份:2014
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
EAGER: Preliminary Study on Novel self-assembled Toroidal-Spiral MicroParticles (TSMPs) for sustained release of therapeutic proteins and peptides: theory and experiments
EAGER:用于持续释放治疗性蛋白质和肽的新型自组装环形螺旋微粒(TSMP)的初步研究:理论和实验
- 批准号:
1039531 - 财政年份:2010
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Materials World Network: Novel Physical Phenomena in Unusual Mesoscopic Superconductors
材料世界网络:异常介观超导体中的新物理现象
- 批准号:
0908700 - 财政年份:2009
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
US-France Cooperative Research: Search for Edge Currents and Domain Walls in SrRu0
美法合作研究:寻找SrRu0中的边缘电流和畴壁
- 批准号:
0340779 - 财政年份:2004
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Experimental Studies of Nanoscopic Superconductors: Half-flux Quantum, Metallic State of Cooper Pairs, and the Berry's Phase
纳米超导体的实验研究:半通量量子、库珀对金属态和贝里相
- 批准号:
0202534 - 财政年份:2002
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant
Determination of the Exact Symmetry of the Pairing State in Sr2RuO4
Sr2RuO4 中配对态精确对称性的测定
- 批准号:
9974327 - 财政年份:1999
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant
CAREER: Mesoscopic Physics of Disordered Superconductors: An Arena for Research and Education
职业:无序超导体的介观物理:研究和教育的舞台
- 批准号:
9702661 - 财政年份:1997
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant
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