MRI: Acquisition of a 600 MHz NMR Spectrometer for Research and Teaching Activities at California State University Northridge

MRI：购买 600 MHz NMR 波谱仪用于加州州立大学北岭分校的研究和教学活动

• 批准号: 1040134
• 负责人: Karin Crowhurst
• 金额: $ 77.24万
• 依托单位: The University Corporation, Northridge
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1040134&HistoricalAwards=false
• 关键词: MRI; Acquisition; 600; MHz; NMR

With this award from the Major Research Instrumentation (MRI) program Professor Karin Crowhurst and colleagues Eric Kelson, Paul Shin, Thomas Minehan and Yann Schrodi from California State University Northridge will acquire a 600 MHz nuclear magnetic resonance (NMR) spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as the investigation of protein dynamics and structure in the neurotrophin and RGS families of signaling proteins; to better understand the mechanisms of signal transmission and regulation; synthesis of C-aryl glycosides to use as nucleoside analogues and for sequence-specific DNA binding; preparation of ruthenium complexes that selectively catalyze inner-sphere hydride transfer to ketones; synthesis of trinuclear group 4 metal complexes to catalyze nitrogen activation/hydrogenation; and design and synthesis of enediyne-based aromatase modulators, a promising class of therapeutics for breast cancer treatment.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists and biochemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.

有了这项来自主要研究仪器（MRI）计划的奖项，来自加州州立大学北岭分校的Karin Crowhurst教授和同事Eric Kelson，Paul Shin，托马斯Minehan和Yann Schrodi将获得600 MHz核磁共振（NMR）光谱仪。该提案旨在加强各级的研究、培训和教育，特别是在研究领域，如神经营养素和RGS信号蛋白家族的蛋白质动力学和结构的调查;更好地了解信号传递和调节的机制;合成用作核苷类似物和序列特异性DNA结合的C-芳基糖苷;制备选择性催化内球氢化物转移到酮的钌络合物;合成三核第4族金属络合物以催化氮活化/氢化;以及基于烯二炔的芳香酶调节剂的设计和合成，核磁共振（NMR）光谱是化学家用于阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家和生物化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分。