MRI: Acquisition of a 600 MHz NMR Spectrometer for Research and Teaching Activities at California State University Northridge

通过这项来自主要研究仪器（MRI）项目的奖励，来自加州州立大学北岭分校的Karin Crowhurst教授及其同事Eric Kelson、Paul Shin、Thomas Minehan和Yann Schrodi将获得一台600 MHz核磁共振（NMR）光谱仪。该提案旨在加强各级的研究培训和教育，特别是在研究领域，如神经营养蛋白和信号蛋白的RGS家族的蛋白质动力学和结构的调查；更好地了解信号传递和调控机制；用于核苷类似物和序列特异性DNA结合的c -芳基糖苷的合成；选择性催化球内氢化物向酮转移的钌配合物的制备三核4族金属配合物催化氮活化/加氢的合成设计和合成以烯二炔为基础的芳香化酶调节剂，这是一种很有前途的乳腺癌治疗药物。核磁共振（NMR）波谱是化学家用来研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家和生物化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机/无机化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分。

With this award from the Major Research Instrumentation (MRI) program Professor Karin Crowhurst and colleagues Eric Kelson, Paul Shin, Thomas Minehan and Yann Schrodi from California State University Northridge will acquire a 600 MHz nuclear magnetic resonance (NMR) spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as the investigation of protein dynamics and structure in the neurotrophin and RGS families of signaling proteins; to better understand the mechanisms of signal transmission and regulation; synthesis of C-aryl glycosides to use as nucleoside analogues and for sequence-specific DNA binding; preparation of ruthenium complexes that selectively catalyze inner-sphere hydride transfer to ketones; synthesis of trinuclear group 4 metal complexes to catalyze nitrogen activation/hydrogenation; and design and synthesis of enediyne-based aromatase modulators, a promising class of therapeutics for breast cancer treatment.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists and biochemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.