MRI: Acquisition of a 600 MHz NMR console
MRI:购买 600 MHz NMR 控制台
基本信息
- 批准号:1229204
- 负责人:
- 金额:$ 17.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2013-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This Major Research Instrumentation award funds the acquisition of a radio-frequency console for a 600 MHz NMR spectrometer which will be operated at the high-field NMR facility of the University at Buffalo (UB), The State University of New York (SUNY). The new console will enable researchers to acquire NMR data of unprecedented quality with high sensitivity and accuracy. Moreover, it will become possible to detect NMR spectra of different types of atomic nuclei simultaneously. The newly developed operating software installed on the console will greatly simplify routine data acquisition and opens new opportunities to implement outstandingly complex NMR experiments. As a result, the new console will enable cutting-edge research in the areas of NMR-based (i) methodology development, (ii) structural biology, (iii) metabolic profiling to diagnose diseases, (iv) studies of organic structures of high interest for nanotechnology, (v) studies of reactive intermediates of enzymatic reactions, (v) investigation of novel types of materials such as solution-derived graphenes and bottle-brush copolymers, (vi) detection of intermediates in organic syntheses and characterization of complex alkaloids related to drug development, and (vii) elucidation of novel reactions to chemically modify proteins in vitro and in vivo. The UB NMR facility is accessible to other academic institutions in the greater Buffalo area, such as the Roswell Park Cancer Research Institute and colleges such as SUNY-Fredonia. Hence, the new console will greatly strengthen the scientific infrastructure of Western New York. Furthermore, undergraduate and graduate students as well as post-doctoral researchers will receive excellent training in applying modern NMR spectroscopy to solve challenging scientific problems of the 21st century. Undergraduate research is aggressively promoted through NSF funded Research Experience for Undergraduates (REU) sites and UB's Collegiate Science and Technology Entry Program (CSTEP) funded by the State of New York State to provide services and resources to talented underrepresented minority students. Research results obtained by using the new console will be disseminated through peer reviewed publications, conference presentations such as posters and talks, and internet based portals, such as the NSF supported NMR 2.0 site (http://www.nmr2.buffalo.edu).
该主要研究仪器奖资助了600 MHz NMR光谱仪的射频控制台的收购,该光谱仪将在布法罗大学(UB)的高场NMR设施中运行,纽约州立大学(SUNY)。新的控制台将使研究人员能够以高灵敏度和准确度获得前所未有的质量NMR数据。此外,同时检测不同类型原子核的NMR光谱将成为可能。安装在控制台上的新开发的操作软件将大大简化常规数据采集,并为实施非常复杂的NMR实验提供新的机会。因此,新的控制台将使基于NMR的前沿研究领域(i)方法学开发,(ii)结构生物学,(iii)诊断疾病的代谢分析,(iv)对纳米技术高度感兴趣的有机结构的研究,(v)酶反应活性中间体的研究,(v)研究新型材料,如溶液衍生的石墨烯和瓶刷共聚物,(vi)检测有机合成中的中间体和表征与药物开发相关的复杂生物碱,和(vii)阐明体外和体内化学修饰蛋白质的新反应。UB NMR设施可供大布法罗地区的其他学术机构使用,如罗斯韦尔公园癌症研究所和纽约州立大学弗雷多尼亚分校等学院。因此,新的控制台将大大加强西纽约的科学基础设施。此外,本科生和研究生以及博士后研究人员将在应用现代核磁共振光谱学解决21世纪世纪具有挑战性的科学问题方面接受出色的培训。通过NSF资助的本科生研究经验(REU)网站和由纽约州资助的UB大学科学和技术入学计划(CSTEP),为有才华的少数民族学生提供服务和资源。通过使用新控制台获得的研究结果将通过同行评审的出版物、会议演示(如海报和演讲)以及基于互联网的门户网站(如NSF支持的NMR 2.0网站(http://www.example.com))进行传播。www.nmr2.buffalo.edu
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas Szyperski其他文献
Evolutionary coupling saturation mutagenesis: Coevolution-guided identification of distant sites influencing Bacillus naganoensis pullulanase activity
进化耦合饱和诱变:共同进化引导识别影响长野芽孢杆菌支链淀粉酶活性的远距离位点
- DOI:
10.1002/1873-3468.13652 - 发表时间:
2020 - 期刊:
- 影响因子:3.5
- 作者:
Xinye Wang;Xiaoran Jing;Yi Deng;Yao Nie;Fei Xu;Yan Xu;Yi-Lei Zhao;John F. Hunt;Gaetano T. Montelione;Thomas Szyperski - 通讯作者:
Thomas Szyperski
13C-NMR, MS and metabolic flux balancing in biotechnology research
- DOI:
10.1017/s0033583598003412 - 发表时间:
1998-02 - 期刊:
- 影响因子:6.1
- 作者:
Thomas Szyperski - 通讯作者:
Thomas Szyperski
NMR with 13C, 15N-doubly-labeled DNA: The shape Antennapedia homeodomain complex with a 14-mer DNA duplex
- DOI:
10.1023/a:1008280117211 - 发表时间:
1998-07-01 - 期刊:
- 影响因子:1.900
- 作者:
César Fernández;Thomas Szyperski;Akira Ono;Hideo Iwai;Shin-ichi Tate;Masatsune Kainosho;Kurt Wüthrich - 通讯作者:
Kurt Wüthrich
Letter to the Editor: 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using Reduced Dimensionality NMR
- DOI:
10.1023/a:1014904502424 - 发表时间:
2002-03-01 - 期刊:
- 影响因子:1.900
- 作者:
Blair R. Szymczyna;Antonio Pineda-Lucena;Jeffrey L. Mills;Thomas Szyperski;Cheryl H. Arrowsmith - 通讯作者:
Cheryl H. Arrowsmith
1H, 13C, and 15N chemical shift assignments of neuronal calcium sensor-1, a multi-functional calcium-binding protein
- DOI:
10.1007/s10858-006-9020-2 - 发表时间:
2006-06-28 - 期刊:
- 影响因子:1.900
- 作者:
Sulakshana Mukherjee;Dasari Muralidhar;Hanudatta S. Atreya;Thomas Szyperski;Andreas Jeromin;Yogendra Sharma;Kandala V. R. Chary - 通讯作者:
Kandala V. R. Chary
Thomas Szyperski的其他文献
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{{ truncateString('Thomas Szyperski', 18)}}的其他基金
Collaborative Research: Energy Landscapes of Designed Cold Unfolding Proteins
合作研究:设计的冷展开蛋白质的能量景观
- 批准号:
2319818 - 财政年份:2023
- 资助金额:
$ 17.55万 - 项目类别:
Standard Grant
Engineering of cold denaturing proteins
冷变性蛋白质的工程
- 批准号:
1615570 - 财政年份:2016
- 资助金额:
$ 17.55万 - 项目类别:
Standard Grant
Methodology for Rapid and Precise Measurement of NMR Parameters: Development and Application to Study Protein Structure and Folding
快速、精确测量 NMR 参数的方法:研究蛋白质结构和折叠的开发和应用
- 批准号:
0817857 - 财政年份:2008
- 资助金额:
$ 17.55万 - 项目类别:
Continuing Grant
Methodology for Rapid NMR Data Acquisition in Structural Genomics
结构基因组学中快速 NMR 数据采集的方法
- 批准号:
0416899 - 财政年份:2004
- 资助金额:
$ 17.55万 - 项目类别:
Continuing Grant
Reduced Dimensionality NMR Spectroscopy for Structural Genomics
结构基因组学的降维核磁共振波谱
- 批准号:
0075773 - 财政年份:2000
- 资助金额:
$ 17.55万 - 项目类别:
Continuing Grant
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