MRI: Acquisition of a 600 MHz NMR console

MRI：购买 600 MHz NMR 控制台

• 批准号: 1229204
• 负责人: Thomas Szyperski
• 金额: $ 17.55万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1229204&HistoricalAwards=false
• 关键词: MRI; Acquisition; 600; MHz; NMR

This Major Research Instrumentation award funds the acquisition of a radio-frequency console for a 600 MHz NMR spectrometer which will be operated at the high-field NMR facility of the University at Buffalo (UB), The State University of New York (SUNY). The new console will enable researchers to acquire NMR data of unprecedented quality with high sensitivity and accuracy. Moreover, it will become possible to detect NMR spectra of different types of atomic nuclei simultaneously. The newly developed operating software installed on the console will greatly simplify routine data acquisition and opens new opportunities to implement outstandingly complex NMR experiments. As a result, the new console will enable cutting-edge research in the areas of NMR-based (i) methodology development, (ii) structural biology, (iii) metabolic profiling to diagnose diseases, (iv) studies of organic structures of high interest for nanotechnology, (v) studies of reactive intermediates of enzymatic reactions, (v) investigation of novel types of materials such as solution-derived graphenes and bottle-brush copolymers, (vi) detection of intermediates in organic syntheses and characterization of complex alkaloids related to drug development, and (vii) elucidation of novel reactions to chemically modify proteins in vitro and in vivo. The UB NMR facility is accessible to other academic institutions in the greater Buffalo area, such as the Roswell Park Cancer Research Institute and colleges such as SUNY-Fredonia. Hence, the new console will greatly strengthen the scientific infrastructure of Western New York. Furthermore, undergraduate and graduate students as well as post-doctoral researchers will receive excellent training in applying modern NMR spectroscopy to solve challenging scientific problems of the 21st century. Undergraduate research is aggressively promoted through NSF funded Research Experience for Undergraduates (REU) sites and UB's Collegiate Science and Technology Entry Program (CSTEP) funded by the State of New York State to provide services and resources to talented underrepresented minority students. Research results obtained by using the new console will be disseminated through peer reviewed publications, conference presentations such as posters and talks, and internet based portals, such as the NSF supported NMR 2.0 site (http://www.nmr2.buffalo.edu).

该主要研究仪器奖资助了600 MHz NMR光谱仪的射频控制台的收购，该光谱仪将在布法罗大学（UB）的高场NMR设施中运行，纽约州立大学（SUNY）。新的控制台将使研究人员能够以高灵敏度和准确度获得前所未有的质量NMR数据。此外，同时检测不同类型原子核的NMR光谱将成为可能。安装在控制台上的新开发的操作软件将大大简化常规数据采集，并为实施非常复杂的NMR实验提供新的机会。因此，新的控制台将使基于NMR的前沿研究领域（i）方法学开发，（ii）结构生物学，（iii）诊断疾病的代谢分析，（iv）对纳米技术高度感兴趣的有机结构的研究，（v）酶反应活性中间体的研究，（v）研究新型材料，如溶液衍生的石墨烯和瓶刷共聚物，（vi）检测有机合成中的中间体和表征与药物开发相关的复杂生物碱，和（vii）阐明体外和体内化学修饰蛋白质的新反应。UB NMR设施可供大布法罗地区的其他学术机构使用，如罗斯韦尔公园癌症研究所和纽约州立大学弗雷多尼亚分校等学院。因此，新的控制台将大大加强西纽约的科学基础设施。此外，本科生和研究生以及博士后研究人员将在应用现代核磁共振光谱学解决21世纪世纪具有挑战性的科学问题方面接受出色的培训。通过NSF资助的本科生研究经验（REU）网站和由纽约州资助的UB大学科学和技术入学计划（CSTEP），为有才华的少数民族学生提供服务和资源。通过使用新控制台获得的研究结果将通过同行评审的出版物、会议演示（如海报和演讲）以及基于互联网的门户网站（如NSF支持的NMR 2.0网站（http：//www.example.com））进行传播。www.nmr2.buffalo.edu