MRI: Acquisition of a 600 MHz NMR console

该主要研究仪器奖为600 MHz核磁共振光谱仪的射频控制台提供资金，该仪器将在布法罗大学（UB）和纽约州立大学（SUNY）的高场核磁共振设施中运行。新的控制台将使研究人员能够以高灵敏度和准确性获得前所未有的质量核磁共振数据。同时探测不同类型原子核的核磁共振谱也将成为可能。安装在控制台上的新开发的操作软件将大大简化常规数据采集，并为实施非常复杂的核磁共振实验开辟了新的机会。因此，新的控制台将使以下领域的前沿研究成为可能：(1)基于核磁共振的方法学开发；(2)结构生物学；(3)诊断疾病的代谢谱分析；(4)纳米技术高度关注的有机结构研究；(5)酶促反应的活性中间体研究；(5)研究新型材料，如溶液衍生石墨烯和瓶刷共聚物。（vi）有机合成中间体的检测和与药物开发相关的复杂生物碱的表征，以及（vii）阐明体外和体内化学修饰蛋白质的新反应。布法罗大学核磁共振设施可供布法罗地区的其他学术机构使用，如罗斯威尔公园癌症研究所和纽约州立大学-弗里多尼亚大学等大学。因此，新的控制台将大大加强纽约西部的科学基础设施。此外，本科生和研究生以及博士后研究人员将接受应用现代核磁共振波谱技术解决21世纪具有挑战性的科学问题的优秀培训。本科研究通过美国国家科学基金会资助的本科生研究经验（REU）网站和UB的大学科学技术入门计划（CSTEP）积极促进，该计划由纽约州资助，为有才华的少数民族学生提供服务和资源。使用新控制台获得的研究结果将通过同行评审出版物、会议演示（如海报和演讲）以及基于互联网的门户网站(如NSF支持的NMR 2.0网站（http://www.nmr2.buffalo.edu）传播。

This Major Research Instrumentation award funds the acquisition of a radio-frequency console for a 600 MHz NMR spectrometer which will be operated at the high-field NMR facility of the University at Buffalo (UB), The State University of New York (SUNY). The new console will enable researchers to acquire NMR data of unprecedented quality with high sensitivity and accuracy. Moreover, it will become possible to detect NMR spectra of different types of atomic nuclei simultaneously. The newly developed operating software installed on the console will greatly simplify routine data acquisition and opens new opportunities to implement outstandingly complex NMR experiments. As a result, the new console will enable cutting-edge research in the areas of NMR-based (i) methodology development, (ii) structural biology, (iii) metabolic profiling to diagnose diseases, (iv) studies of organic structures of high interest for nanotechnology, (v) studies of reactive intermediates of enzymatic reactions, (v) investigation of novel types of materials such as solution-derived graphenes and bottle-brush copolymers, (vi) detection of intermediates in organic syntheses and characterization of complex alkaloids related to drug development, and (vii) elucidation of novel reactions to chemically modify proteins in vitro and in vivo. The UB NMR facility is accessible to other academic institutions in the greater Buffalo area, such as the Roswell Park Cancer Research Institute and colleges such as SUNY-Fredonia. Hence, the new console will greatly strengthen the scientific infrastructure of Western New York. Furthermore, undergraduate and graduate students as well as post-doctoral researchers will receive excellent training in applying modern NMR spectroscopy to solve challenging scientific problems of the 21st century. Undergraduate research is aggressively promoted through NSF funded Research Experience for Undergraduates (REU) sites and UB's Collegiate Science and Technology Entry Program (CSTEP) funded by the State of New York State to provide services and resources to talented underrepresented minority students. Research results obtained by using the new console will be disseminated through peer reviewed publications, conference presentations such as posters and talks, and internet based portals, such as the NSF supported NMR 2.0 site (http://www.nmr2.buffalo.edu).