MRI: Acquisition of a 600 MHz NMR console
MRI:购买 600 MHz NMR 控制台
基本信息
- 批准号:1229204
- 负责人:
- 金额:$ 17.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2013-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This Major Research Instrumentation award funds the acquisition of a radio-frequency console for a 600 MHz NMR spectrometer which will be operated at the high-field NMR facility of the University at Buffalo (UB), The State University of New York (SUNY). The new console will enable researchers to acquire NMR data of unprecedented quality with high sensitivity and accuracy. Moreover, it will become possible to detect NMR spectra of different types of atomic nuclei simultaneously. The newly developed operating software installed on the console will greatly simplify routine data acquisition and opens new opportunities to implement outstandingly complex NMR experiments. As a result, the new console will enable cutting-edge research in the areas of NMR-based (i) methodology development, (ii) structural biology, (iii) metabolic profiling to diagnose diseases, (iv) studies of organic structures of high interest for nanotechnology, (v) studies of reactive intermediates of enzymatic reactions, (v) investigation of novel types of materials such as solution-derived graphenes and bottle-brush copolymers, (vi) detection of intermediates in organic syntheses and characterization of complex alkaloids related to drug development, and (vii) elucidation of novel reactions to chemically modify proteins in vitro and in vivo. The UB NMR facility is accessible to other academic institutions in the greater Buffalo area, such as the Roswell Park Cancer Research Institute and colleges such as SUNY-Fredonia. Hence, the new console will greatly strengthen the scientific infrastructure of Western New York. Furthermore, undergraduate and graduate students as well as post-doctoral researchers will receive excellent training in applying modern NMR spectroscopy to solve challenging scientific problems of the 21st century. Undergraduate research is aggressively promoted through NSF funded Research Experience for Undergraduates (REU) sites and UB's Collegiate Science and Technology Entry Program (CSTEP) funded by the State of New York State to provide services and resources to talented underrepresented minority students. Research results obtained by using the new console will be disseminated through peer reviewed publications, conference presentations such as posters and talks, and internet based portals, such as the NSF supported NMR 2.0 site (http://www.nmr2.buffalo.edu).
这一重大研究仪器奖为购买600 MHz核磁共振光谱仪的射频控制台提供资金,该光谱仪将在纽约州立大学布法罗分校(UB)的高场核磁共振设施中运行。新的控制台将使研究人员能够以高灵敏度和准确性获得前所未有的高质量核磁共振数据。此外,还将有可能同时检测不同类型原子核的核磁共振谱。安装在控制台上的新开发的操作软件将极大地简化常规数据采集,并为实施极其复杂的核磁共振实验打开新的机会。因此,新的控制台将使以下领域的尖端研究成为可能:(I)方法学开发;(Ii)结构生物学;(Iii)诊断疾病的代谢图谱;(Iv)纳米技术感兴趣的有机结构研究;(V)酶反应的活性中间体研究;(V)溶液衍生石墨烯和瓶刷共聚物等新型材料的研究;(Vi)有机合成中间体的检测和与药物开发相关的复杂生物碱的表征;以及(Vii)阐明在体外和体内对蛋白质进行化学修饰的新反应。大布法罗地区的其他学术机构,如罗斯韦尔公园癌症研究所和纽约州立大学弗雷多尼亚分校等学院,都可以使用UB核磁共振设备。因此,新的游戏机将大大加强纽约西部的科学基础设施。此外,本科生和研究生以及博士后研究人员将接受应用现代核磁共振光谱学解决21世纪具有挑战性的科学问题的出色培训。通过NSF资助的本科生研究体验(REU)网站和纽约州资助的UB大学科学和技术进入计划(CSTEP),积极促进本科生研究,为有才华的未被充分代表的少数族裔学生提供服务和资源。通过使用新控制台获得的研究成果将通过同行评议的出版物、海报和演讲等会议演示文稿以及基于互联网的门户网站(如NSF支持的NMR2.0站点(http://www.nmr2.buffalo.edu).))进行传播
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas Szyperski其他文献
Evolutionary coupling saturation mutagenesis: Coevolution-guided identification of distant sites influencing Bacillus naganoensis pullulanase activity
进化耦合饱和诱变:共同进化引导识别影响长野芽孢杆菌支链淀粉酶活性的远距离位点
- DOI:
10.1002/1873-3468.13652 - 发表时间:
2020 - 期刊:
- 影响因子:3.5
- 作者:
Xinye Wang;Xiaoran Jing;Yi Deng;Yao Nie;Fei Xu;Yan Xu;Yi-Lei Zhao;John F. Hunt;Gaetano T. Montelione;Thomas Szyperski - 通讯作者:
Thomas Szyperski
13C-NMR, MS and metabolic flux balancing in biotechnology research
- DOI:
10.1017/s0033583598003412 - 发表时间:
1998-02 - 期刊:
- 影响因子:6.1
- 作者:
Thomas Szyperski - 通讯作者:
Thomas Szyperski
NMR with 13C, 15N-doubly-labeled DNA: The shape Antennapedia homeodomain complex with a 14-mer DNA duplex
- DOI:
10.1023/a:1008280117211 - 发表时间:
1998-07-01 - 期刊:
- 影响因子:1.900
- 作者:
César Fernández;Thomas Szyperski;Akira Ono;Hideo Iwai;Shin-ichi Tate;Masatsune Kainosho;Kurt Wüthrich - 通讯作者:
Kurt Wüthrich
Letter to the Editor: 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using Reduced Dimensionality NMR
- DOI:
10.1023/a:1014904502424 - 发表时间:
2002-03-01 - 期刊:
- 影响因子:1.900
- 作者:
Blair R. Szymczyna;Antonio Pineda-Lucena;Jeffrey L. Mills;Thomas Szyperski;Cheryl H. Arrowsmith - 通讯作者:
Cheryl H. Arrowsmith
1H, 13C, and 15N chemical shift assignments of neuronal calcium sensor-1, a multi-functional calcium-binding protein
- DOI:
10.1007/s10858-006-9020-2 - 发表时间:
2006-06-28 - 期刊:
- 影响因子:1.900
- 作者:
Sulakshana Mukherjee;Dasari Muralidhar;Hanudatta S. Atreya;Thomas Szyperski;Andreas Jeromin;Yogendra Sharma;Kandala V. R. Chary - 通讯作者:
Kandala V. R. Chary
Thomas Szyperski的其他文献
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{{ truncateString('Thomas Szyperski', 18)}}的其他基金
Collaborative Research: Energy Landscapes of Designed Cold Unfolding Proteins
合作研究:设计的冷展开蛋白质的能量景观
- 批准号:
2319818 - 财政年份:2023
- 资助金额:
$ 17.55万 - 项目类别:
Standard Grant
Engineering of cold denaturing proteins
冷变性蛋白质的工程
- 批准号:
1615570 - 财政年份:2016
- 资助金额:
$ 17.55万 - 项目类别:
Standard Grant
Methodology for Rapid and Precise Measurement of NMR Parameters: Development and Application to Study Protein Structure and Folding
快速、精确测量 NMR 参数的方法:研究蛋白质结构和折叠的开发和应用
- 批准号:
0817857 - 财政年份:2008
- 资助金额:
$ 17.55万 - 项目类别:
Continuing Grant
Methodology for Rapid NMR Data Acquisition in Structural Genomics
结构基因组学中快速 NMR 数据采集的方法
- 批准号:
0416899 - 财政年份:2004
- 资助金额:
$ 17.55万 - 项目类别:
Continuing Grant
Reduced Dimensionality NMR Spectroscopy for Structural Genomics
结构基因组学的降维核磁共振波谱
- 批准号:
0075773 - 财政年份:2000
- 资助金额:
$ 17.55万 - 项目类别:
Continuing Grant
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