MRI: Acquisition of a 600 MHz NMR Spectrometer

MRI：购买 600 MHz NMR 波谱仪

• 批准号: 2216220
• 负责人: Bruce Gibb
• 金额: $ 79.88万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216220&HistoricalAwards=false
• 关键词: MRI; Acquisition; 600; MHz; NMR

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Tulane University is acquiring a 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a helium-cooled probe to support the research of Professor Bruce Gibb and colleagues Nathalie Busschaert, Stassi DiMaggio, and Janarthanan Jayawickramarajah. This instrument facilitates research in the areas of structural biology, supramolecular chemistry, polymer chemistry, and organic chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of a diverse population of students at all levels. This instrument enables these activities for over 16 research groups from Tulane University and regional institutions in the New Orleans, southeast Louisiana, and southern Mississippi regions including Xavier University and Loyola University of New Orleans. The award of the 600 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic polymers, superconductors, membrane structures, inorganic complexes, and host guest interactions. This instrument enables research in a variety of projects including the synthesis of polymer architectures, supramolecular chemistry at membranes, characterization of nano-material platforms for drug-delivery, and the identification and characterization of inorganic complexes. It also assists in the study of abiotic and biotic aqueous supramolecular chemistry, polymer design for drug delivery, and the structure of functionalized synthetic DNA-based assemblies. Further investigations include designing agents for cancer cell imaging, studying polypeptiod interactions with lipid bilayers, conformational flexibility in CD4+ T-cell epitope processing, the synthesis of low-coordinate, low-valent metal complexes, and the NMR detection of small molecule binding to target proteins. Additionally, the instrument facilitates the understanding of the unusual structure and bonding in complex aromatic molecules, the development of novel organic superconductors, transition metal complex chromophores and light harvesting ensembles, catalysis with porous materials, and new rhodamine dyes as chiral sensors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具和化学研究工具计划共同支持。杜兰大学（Tulane University）正在购买配备氦冷探针的600 MHz核磁共振（NMR）光谱仪，以支持Bruce Gibb教授和同事Nathalie Busschaert，Stassi Dimaggio和Janarthanan Jayawickramarajah的研究。该仪器促进了在结构生物学，超分子化学，聚合物化学和有机化学领域的研究。通常，核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子或固态中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。相对于标准NMR探针，低温探针可显着提高灵敏度。该工具增强了各个级别的各种学生人群的教育，研究和教学工作。 该工具可以为来自杜兰大学的16多个研究小组以及新奥尔良，路易斯安那州东南部的区域机构以及包括Xavier大学和新奥尔良洛约拉大学在内的南部密西西比州地区提供这些活动。 600 MHz NMR光谱仪的奖励旨在增强各个级别的研究和教育，尤其是在合成聚合物，超导体，膜结构，无机络合物和宿主访客互动等领域。该仪器能够在各种项目中进行研究，包括聚合物架构的合成，膜上的超分子化学，用于药物传递的纳米材料平台的表征以及无机复合物的识别和表征。 它还有助于研究非生物和生物水性超分子化学，药物输送的聚合物设计以及基于合成DNA的组件的结构。进一步的研究包括设计用于癌细胞成像的剂，研究与脂质双层的多肽相互作用，CD4+ T细胞表位加工中的构象柔韧性，低坐标，低价值金属复合物的合成以及小分子与靶蛋白的NMR检测。 此外，该仪器促进了对复杂芳族分子中异常结构和键合的理解，新型有机超导体的发展，过渡金属金属复杂的发色团和光收集的光收集，用多孔材料进行催化以及新的若丹明染料作为手性传感器的新犀牛染料。影响审查标准。