MRI: Acquisition of a 600 MHz NMR Spectrometer

该奖项由主要研究仪器项目和化学研究仪器项目共同支持。杜兰大学正在获取一台配备氦冷却探测器的600 MHz核磁共振(核磁共振)光谱仪，以支持布鲁斯·吉布教授及其同事Nathalie Busschaert、Stassi DiMaggio和Janarthan an Jayawickramarajah的研究。该仪器促进了结构生物学、超分子化学、聚合物化学和有机化学领域的研究。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。相对于标准的核磁共振探头，低温探头的灵敏度显著提高。这一工具加强了各级各类学生的教育、研究和教学工作。该仪器使来自杜兰大学和新奥尔良、路易斯安那州东南部和密西西比州南部地区的区域机构(包括新奥尔良的泽维尔大学和洛约拉大学)的16个以上研究小组能够开展这些活动。600 MHz核磁共振光谱仪的获奖旨在加强所有级别的研究和教育，特别是在合成聚合物、超导体、膜结构、无机络合物和主-客相互作用等领域。该仪器可用于各种项目的研究，包括聚合物结构的合成、膜的超分子化学、用于药物输送的纳米材料平台的表征以及无机络合物的鉴定和表征。它还帮助研究非生物和生物的水相超分子化学，药物输送的聚合物设计，以及基于DNA的功能化合成组件的结构。进一步的研究包括设计癌细胞显像剂，研究多肽与脂质双层的相互作用，CD4+T细胞表位处理中的构象灵活性，低配位、低价金属络合物的合成，以及与目标蛋白质结合的小分子的核磁共振检测。此外，该仪器还有助于了解复杂芳香族分子中的特殊结构和成键、新型有机超导体、过渡金属络合物发色团和集光材料的开发、多孔材料的催化作用以及作为手性传感器的新型罗丹明染料。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Tulane University is acquiring a 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a helium-cooled probe to support the research of Professor Bruce Gibb and colleagues Nathalie Busschaert, Stassi DiMaggio, and Janarthanan Jayawickramarajah. This instrument facilitates research in the areas of structural biology, supramolecular chemistry, polymer chemistry, and organic chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of a diverse population of students at all levels. This instrument enables these activities for over 16 research groups from Tulane University and regional institutions in the New Orleans, southeast Louisiana, and southern Mississippi regions including Xavier University and Loyola University of New Orleans. The award of the 600 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic polymers, superconductors, membrane structures, inorganic complexes, and host guest interactions. This instrument enables research in a variety of projects including the synthesis of polymer architectures, supramolecular chemistry at membranes, characterization of nano-material platforms for drug-delivery, and the identification and characterization of inorganic complexes. It also assists in the study of abiotic and biotic aqueous supramolecular chemistry, polymer design for drug delivery, and the structure of functionalized synthetic DNA-based assemblies. Further investigations include designing agents for cancer cell imaging, studying polypeptiod interactions with lipid bilayers, conformational flexibility in CD4+ T-cell epitope processing, the synthesis of low-coordinate, low-valent metal complexes, and the NMR detection of small molecule binding to target proteins. Additionally, the instrument facilitates the understanding of the unusual structure and bonding in complex aromatic molecules, the development of novel organic superconductors, transition metal complex chromophores and light harvesting ensembles, catalysis with porous materials, and new rhodamine dyes as chiral sensors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.