MRI: Acquisition of a 600 MHz NMR Spectrometer

MRI：购买 600 MHz NMR 波谱仪

• 批准号: 2216220
• 负责人: Bruce Gibb
• 金额: $ 79.88万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216220&HistoricalAwards=false
• 关键词: MRI; Acquisition; 600; MHz; NMR

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Tulane University is acquiring a 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a helium-cooled probe to support the research of Professor Bruce Gibb and colleagues Nathalie Busschaert, Stassi DiMaggio, and Janarthanan Jayawickramarajah. This instrument facilitates research in the areas of structural biology, supramolecular chemistry, polymer chemistry, and organic chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of a diverse population of students at all levels. This instrument enables these activities for over 16 research groups from Tulane University and regional institutions in the New Orleans, southeast Louisiana, and southern Mississippi regions including Xavier University and Loyola University of New Orleans. The award of the 600 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic polymers, superconductors, membrane structures, inorganic complexes, and host guest interactions. This instrument enables research in a variety of projects including the synthesis of polymer architectures, supramolecular chemistry at membranes, characterization of nano-material platforms for drug-delivery, and the identification and characterization of inorganic complexes. It also assists in the study of abiotic and biotic aqueous supramolecular chemistry, polymer design for drug delivery, and the structure of functionalized synthetic DNA-based assemblies. Further investigations include designing agents for cancer cell imaging, studying polypeptiod interactions with lipid bilayers, conformational flexibility in CD4+ T-cell epitope processing, the synthesis of low-coordinate, low-valent metal complexes, and the NMR detection of small molecule binding to target proteins. Additionally, the instrument facilitates the understanding of the unusual structure and bonding in complex aromatic molecules, the development of novel organic superconductors, transition metal complex chromophores and light harvesting ensembles, catalysis with porous materials, and new rhodamine dyes as chiral sensors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目联合支持。杜兰大学正在购买一台配备氦冷却探针的600兆赫核磁共振（NMR）光谱仪，以支持Bruce Gibb教授及其同事Nathalie Busschaert， Stassi DiMaggio和Janarthanan Jayawickramarajah的研究。该仪器促进了结构生物学、超分子化学、聚合物化学和有机化学等领域的研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。低温探针相对于标准核磁共振探针提供了显著的灵敏度增加。这一工具加强了各级不同学生群体的教育、研究和教学努力。该仪器使来自杜兰大学和新奥尔良、路易斯安那州东南部和密西西比南部地区的区域机构（包括泽维尔大学和新奥尔良洛约拉大学）的16个研究小组能够进行这些活动。600兆赫核磁共振光谱仪的授予旨在加强各级的研究和教育，特别是在合成聚合物、超导体、膜结构、无机复合物和主客相互作用等领域。该仪器可用于多种项目的研究，包括聚合物结构的合成、膜上的超分子化学、纳米材料给药平台的表征以及无机复合物的鉴定和表征。它还协助研究非生物和生物水超分子化学，用于药物递送的聚合物设计以及基于dna的功能化合成组件的结构。进一步的研究包括设计用于癌细胞成像的药物，研究多肽与脂质双层的相互作用，CD4+ t细胞表位加工中的构象灵活性，低配位，低价金属配合物的合成，以及与靶蛋白结合的小分子的核磁共振检测。此外，该仪器有助于理解复杂芳香分子的异常结构和键合，新型有机超导体的发展，过渡金属复合发色团和光收集集合，多孔材料的催化作用，以及新的罗丹明染料作为手性传感器。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。