MRI: Acquisition of a 600 MHz NMR Spectrometer

MRI：购买 600 MHz NMR 波谱仪

• 批准号: 2216220
• 负责人: Bruce Gibb
• 金额: $ 79.88万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216220&HistoricalAwards=false
• 关键词: MRI; Acquisition; 600; MHz; NMR

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Tulane University is acquiring a 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a helium-cooled probe to support the research of Professor Bruce Gibb and colleagues Nathalie Busschaert, Stassi DiMaggio, and Janarthanan Jayawickramarajah. This instrument facilitates research in the areas of structural biology, supramolecular chemistry, polymer chemistry, and organic chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of a diverse population of students at all levels. This instrument enables these activities for over 16 research groups from Tulane University and regional institutions in the New Orleans, southeast Louisiana, and southern Mississippi regions including Xavier University and Loyola University of New Orleans. The award of the 600 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic polymers, superconductors, membrane structures, inorganic complexes, and host guest interactions. This instrument enables research in a variety of projects including the synthesis of polymer architectures, supramolecular chemistry at membranes, characterization of nano-material platforms for drug-delivery, and the identification and characterization of inorganic complexes. It also assists in the study of abiotic and biotic aqueous supramolecular chemistry, polymer design for drug delivery, and the structure of functionalized synthetic DNA-based assemblies. Further investigations include designing agents for cancer cell imaging, studying polypeptiod interactions with lipid bilayers, conformational flexibility in CD4+ T-cell epitope processing, the synthesis of low-coordinate, low-valent metal complexes, and the NMR detection of small molecule binding to target proteins. Additionally, the instrument facilitates the understanding of the unusual structure and bonding in complex aromatic molecules, the development of novel organic superconductors, transition metal complex chromophores and light harvesting ensembles, catalysis with porous materials, and new rhodamine dyes as chiral sensors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由重大研究仪器项目和化学研究仪器项目联合资助。杜兰大学正在购买一台配备氦冷探头的 600 MHz 核磁共振 (NMR) 波谱仪，以支持 Bruce Gibb 教授及其同事 Nathalie Busschaert、Stassi DiMaggio 和 Janarthanan Jayawickramarajah 的研究。该仪器促进了结构生物学、超分子化学、高分子化学和有机化学领域的研究。一般来说，核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。相对于标准 NMR 探头，低温探头的灵敏度显着提高。该工具增强了各级各类学生的教育、研究和教学工作。 该工具为来自杜兰大学以及新奥尔良、路易斯安那州东南部和密西西比州南部地区机构（包括泽维尔大学和新奥尔良洛约拉大学）的超过 16 个研究小组提供了这些活动。 600 MHz核磁共振波谱仪的获奖旨在加强各个层面的研究和教育，特别是在合成聚合物、超导体、膜结构、无机复合物和主客体相互作用等领域。该仪器可用于各种项目的研究，包括聚合物结构的合成、膜的超分子化学、药物输送纳米材料平台的表征以及无机复合物的识别和表征。 它还有助于研究非生物和生物水性超分子化学、药物输送聚合物设计以及功能化合成 DNA 组装体的结构。进一步的研究包括设计用于癌细胞成像的试剂、研究多肽与脂质双层的相互作用、CD4+T细胞表位加工中的构象灵活性、低配位、低价金属复合物的合成，以及小分子与靶蛋白结合的NMR检测。 此外，该仪器有助于理解复杂芳香分子中的异常结构和键合、新型有机超导体、过渡金属复杂发色团和光捕获整体的开发、多孔材料的催化以及作为手性传感器的新型罗丹明染料。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优势和更广泛的评估进行评估，认为值得支持。 影响审查标准。