MRI: Acquisition of a 400 MHz NMR Spectrometer to Enhance Faculty and Undergraduate Research at Hendrix College

有了这个奖项从主要研究仪器（MRI）计划教授托马斯古德温和同事克里斯托弗马文和安德烈斯卡罗从亨德里克斯学院将获得400兆赫核磁共振（NMR）光谱仪。该提案旨在加强各级的研究培训和教育，特别是在研究领域，如吡咯基生物活性海洋生物碱类似物和同位素标记华法林代谢物的合成;哺乳动物化学信号和代谢物的发现和表征，在大象，狐猴和鬃毛狼;绿色微型实验的介绍有机化学实验室的发展;通过非对映选择性烯烃交叉复分解的非手性/mesodienes的去对称化;为合成杂环分子的催化光氧化还原过程的发展;抗菌和细胞毒性黄烷酮的合成;以及通过使用31 P NMR测量生物能量学和通过关联脂肪酸亚甲基/甲基比率（1H NMR）研究肝细胞中细胞色素P450亚型2 E1对线粒体的氧化损伤核磁共振（NMR）光谱是化学家可用于阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分。

With this award from the Major Research Instrumentation (MRI) program Professor Thomas Goodwin and colleague Christopher Marvin and Andres Caro from Hendrix College will acquire a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as synthesis of pyrrole-based, biologically active marine alkaloid analogues and isotopically-labeled warfarin metabolites; discovery and characterization of mammalian chemical signals and metabolites, e.g., in elephants, lemurs, and maned wolves; development of green microscale experiments for the introductory organic chemistry laboratory; desymmetrization of achiral/mesodienes via diastereoselective alkene cross metathesis; development of catalytic photoredox processes for the synthesis of heterocyclic molecules; synthesis of antibacterial and cytotoxic flavanones; and study of oxidative mitochondrial damage by cytochrome P450 isoform 2E1 in hepatocytes by measuring bioenergetics using 31P NMR and by correlating fatty acidmethylene/methyl ratios (1H NMR) corresponding to the onset of apoptosis.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.