MRI: Acquisition of a 400 MHz NMR Spectrometer to Enhance Faculty and Undergraduate Research at Hendrix College

获得重大研究仪器(MRI)项目颁发的这一奖项后，亨德里克斯学院的Thomas Goodwin教授及其同事Christopher Marvin和Andres Caro将获得一台400 MHz核磁共振(核磁共振)光谱仪。该建议旨在加强各级的研究培训和教育，特别是在以下研究领域：合成基于吡咯的具有生物活性的海洋生物碱类似物和同位素标记的华法林代谢物；发现和表征哺乳动物的化学信号和代谢物，例如在大象、狐猴和螳螂身上；为介绍性有机化学实验室开发绿色微型实验；通过非对映选择性的烯烃交叉歧化来去对称化非手性/均二烯；开发用于合成杂环分子的催化光氧化还原工艺；抗菌和有毒细胞黄酮类的合成；并通过使用31P核磁共振测量生物能量学和通过相关脂肪酸亚甲基/甲基比率(1H核磁共振)来研究细胞色素P450异构体2E1对肝细胞线粒体的氧化损伤。核磁共振光谱是化学家可用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究不可或缺的一部分。

With this award from the Major Research Instrumentation (MRI) program Professor Thomas Goodwin and colleague Christopher Marvin and Andres Caro from Hendrix College will acquire a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as synthesis of pyrrole-based, biologically active marine alkaloid analogues and isotopically-labeled warfarin metabolites; discovery and characterization of mammalian chemical signals and metabolites, e.g., in elephants, lemurs, and maned wolves; development of green microscale experiments for the introductory organic chemistry laboratory; desymmetrization of achiral/mesodienes via diastereoselective alkene cross metathesis; development of catalytic photoredox processes for the synthesis of heterocyclic molecules; synthesis of antibacterial and cytotoxic flavanones; and study of oxidative mitochondrial damage by cytochrome P450 isoform 2E1 in hepatocytes by measuring bioenergetics using 31P NMR and by correlating fatty acidmethylene/methyl ratios (1H NMR) corresponding to the onset of apoptosis.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.