MRI: Acquisition of a 400 MHz NMR Spectrometer to Enhance Faculty and Undergraduate Research at Hendrix College

该奖项来自主要研究仪器（MRI）项目，Thomas Goodwin教授及其同事Christopher Marvin和hendrx学院的Andres Caro将获得一台400 MHz核磁共振（NMR）光谱仪。该建议的目的是加强各级的研究培训和教育，特别是在诸如吡罗基生物活性海洋生物碱类似物和同位素标记华法林代谢物的合成等研究领域；哺乳动物化学信号和代谢物的发现和表征，例如大象、狐猴和鬃狼；有机化学导论实验室绿色微尺度实验的开发非手性/中二甲苯的非对映选择性烯烃交叉复合脱对称催化光氧化还原法合成杂环分子的研究进展抗菌和细胞毒性黄酮的合成以及通过使用31P核磁共振测量生物能量和通过关联与凋亡发生相对应的脂肪酸亚甲基/甲基比（1H核磁共振）来研究肝细胞色素P450异构体2E1对线粒体氧化损伤的影响。核磁共振（NMR）波谱是化学家用来研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分。

With this award from the Major Research Instrumentation (MRI) program Professor Thomas Goodwin and colleague Christopher Marvin and Andres Caro from Hendrix College will acquire a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as synthesis of pyrrole-based, biologically active marine alkaloid analogues and isotopically-labeled warfarin metabolites; discovery and characterization of mammalian chemical signals and metabolites, e.g., in elephants, lemurs, and maned wolves; development of green microscale experiments for the introductory organic chemistry laboratory; desymmetrization of achiral/mesodienes via diastereoselective alkene cross metathesis; development of catalytic photoredox processes for the synthesis of heterocyclic molecules; synthesis of antibacterial and cytotoxic flavanones; and study of oxidative mitochondrial damage by cytochrome P450 isoform 2E1 in hepatocytes by measuring bioenergetics using 31P NMR and by correlating fatty acidmethylene/methyl ratios (1H NMR) corresponding to the onset of apoptosis.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.