CAREER: Toward Biocompatible, Bi-directional, and Multi-channel Magnetic Neural Implants

职业：生物相容性、双向和多通道磁性神经植入物

• 批准号: 1055269
• 负责人: Wen Li
• 金额: $ 40万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1055269&HistoricalAwards=false
• 关键词: CAREER; Toward; Biocompatible; Bi; directional

ECCS-1055269Wen Li, Michigan State UniversityCAREER: Toward Biocompatible, Bi-directional, and Multi-channel Magnetic Neural ImplantsABSTRACTThe objective of this research is to fully realize biocompatible magnetic microsystems that permit seamless interfacing with nervous systems for studying and treating neural injuries and/or diseases. The approach is to integrate microcoil arrays and control microelectronics on a single platform for bi-directional and multi-site electromagnetic neural communication, utilizing flexible and biocompatible polymers as main structural and packaging materials to minimize bioreactivity and biofouling.Intellectual Merit: Invention of new biomedical implants capable of monitoring and manipulating localized bio-electromagnetic fields will help reveal unknown cause-effect relationships between electrical and magnetic signals in biological systems. The developed polymer-based microfabrication and integration technologies can be broadly applicable to other bioimplants. In-depth understanding of neural responses to localized magnetic fields will lay the foundation for new neural-machine-interfaces in neurophysiology and clinical neurology, and ultimately neural implants that provide bi-directional electromagnetic guidance cues to enable neural circuit re-growth and lost neural function restoration.Broader Impacts: The proposed research will create valuable tools to advance neuroscience and lead to new neural prostheses and therapies. Direct benefits to the society include the reduction of national healthcare cost and life quality improvement for patients suffering neural injuries and diseases. This work will offer multidisciplinary research experiences for undergraduate and graduate students, promote university curriculum development, and assist in supporting and retaining female and minority students through early exposure to science and engineering. Integrated outreach programs combining open-lab tours, summer camps, and teacher training will effectively convert state-of-art science into educational resources accessible to local K-12 schools and communities.

ECCS-1055269李文，密歇根州立大学职业生涯：走向生物相容性，双向，多通道磁性神经植入物摘要本研究的目的是充分实现生物相容性的磁性微系统，允许无缝接口与神经系统的研究和治疗神经损伤和/或疾病。 该方法是将微线圈阵列和控制微电子设备集成在一个平台上，用于双向和多站点电磁神经通信，利用柔性和生物相容性聚合物作为主要结构和包装材料，以最大限度地减少生物活性和生物污染。发明能够监测和操纵局部生物电磁场的新生物医学植入物将有助于揭示未知原因-影响生物系统中电信号和磁信号之间的关系。 所开发的基于聚合物的微加工和集成技术可广泛应用于其他生物植入物。 深入了解局部磁场对神经系统的影响，将为神经生理学和临床神经病学领域的新型神经-机器接口奠定基础，并最终为神经植入物提供双向电磁引导线索，使神经回路重新生长和失去的神经功能恢复。更广泛的影响：拟议的研究将为推进神经科学创造有价值的工具，并导致新的神经假体和治疗方法。 对社会的直接好处包括降低国家医疗成本和改善神经损伤和疾病患者的生活质量。 这项工作将为本科生和研究生提供多学科的研究经验，促进大学课程的发展，并通过早期接触科学和工程，帮助支持和留住女性和少数民族学生。 结合开放实验室图尔斯之旅、夏令营和教师培训的综合推广计划将有效地将最先进的科学转化为当地K-12学校和社区可以使用的教育资源。