CAREER: Toward Biocompatible, Bi-directional, and Multi-channel Magnetic Neural Implants

李文，美国密歇根州立大学研究方向：生物相容性、双向、多通道磁性神经植入物摘要本研究的目的是充分实现生物相容性磁性微系统，使其能够与神经系统无缝连接，用于神经损伤和/或疾病的研究和治疗。该方法是将微线圈阵列和控制微电子集成在一个双向和多站点电磁神经通信的单一平台上，利用柔性和生物相容性聚合物作为主要结构和包装材料，以最大限度地减少生物反应性和生物污染。智力优势：能够监测和操纵局部生物电磁场的新型生物医学植入物的发明将有助于揭示生物系统中电信号和磁信号之间未知的因果关系。所开发的基于聚合物的微加工和集成技术可以广泛应用于其他生物植入物。深入了解局部磁场下的神经反应将为神经生理学和临床神经学中新的神经-机器接口奠定基础，并最终为神经植入物提供双向电磁引导线索，使神经回路再生和失去的神经功能恢复。更广泛的影响：拟议的研究将创造有价值的工具来推进神经科学，并导致新的神经假体和治疗。对社会的直接效益包括降低国家医疗保健费用和改善神经损伤和疾病患者的生活质量。这项工作将为本科生和研究生提供多学科研究经验，促进大学课程发展，并通过早期接触科学和工程帮助支持和留住女性和少数民族学生。结合开放实验室参观、夏令营和教师培训的综合推广计划将有效地将最先进的科学转化为当地K-12学校和社区可获得的教育资源。

ECCS-1055269Wen Li, Michigan State UniversityCAREER: Toward Biocompatible, Bi-directional, and Multi-channel Magnetic Neural ImplantsABSTRACTThe objective of this research is to fully realize biocompatible magnetic microsystems that permit seamless interfacing with nervous systems for studying and treating neural injuries and/or diseases. The approach is to integrate microcoil arrays and control microelectronics on a single platform for bi-directional and multi-site electromagnetic neural communication, utilizing flexible and biocompatible polymers as main structural and packaging materials to minimize bioreactivity and biofouling.Intellectual Merit: Invention of new biomedical implants capable of monitoring and manipulating localized bio-electromagnetic fields will help reveal unknown cause-effect relationships between electrical and magnetic signals in biological systems. The developed polymer-based microfabrication and integration technologies can be broadly applicable to other bioimplants. In-depth understanding of neural responses to localized magnetic fields will lay the foundation for new neural-machine-interfaces in neurophysiology and clinical neurology, and ultimately neural implants that provide bi-directional electromagnetic guidance cues to enable neural circuit re-growth and lost neural function restoration.Broader Impacts: The proposed research will create valuable tools to advance neuroscience and lead to new neural prostheses and therapies. Direct benefits to the society include the reduction of national healthcare cost and life quality improvement for patients suffering neural injuries and diseases. This work will offer multidisciplinary research experiences for undergraduate and graduate students, promote university curriculum development, and assist in supporting and retaining female and minority students through early exposure to science and engineering. Integrated outreach programs combining open-lab tours, summer camps, and teacher training will effectively convert state-of-art science into educational resources accessible to local K-12 schools and communities.