RUI: Use of Functionalized Dendrimers in Cascade Catalysis

RUI：功能化树枝状聚合物在级联催化中的应用

• 批准号: 1057690
• 负责人: Thomas Jones
• 金额: $ 12.75万
• 依托单位: College of Saint Benedict
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1057690&HistoricalAwards=false
• 关键词: RUI; Use; Functionalized; Dendrimers; Cascade

The Chemical Catalysis Program in the Chemistry Division at the National Science Foundation supports Professor Thomas Jones of the College of Saint Benedict, for the synthesis, characterization and evaluation of multifunctional dendritic cascade catalysts. The goal of this work is to attach both metal and organometallic catalysts to the perimeter of G4 poly(amido amine) dendrimers, and to make subsequent kinetic and mechanistic studies in regard to catalyst optimization. Cascade catalysts are important for the development of multi-step, one-pot reactions in organic chemistry.Broader impacts of the research are based on the general development of "atom economical" reactions, which are critical for the reduction of the waste stream in the chemical industry and can save time during labor intensive pharmaceutical multistep syntheses. The research by Professor Jones, in collaboration with Professor Cloninger at Montana State University, is geared to the training of undergraduate researchers in synthesis, characterization by a variety of analytical methods, and mechanistic and kinetic measurements.

美国国家科学基金会化学部的化学催化项目支持圣本笃学院的托马斯琼斯教授合成、表征和评估多功能树枝状级联催化剂。 这项工作的目标是将金属和有机金属催化剂连接到G4聚（酰胺胺）树枝状聚合物的周边，并进行后续的动力学和机理研究方面的催化剂优化。 级联催化剂对于有机化学中多步一锅法反应的发展是非常重要的。该研究的更广泛影响是基于“原子经济”反应的普遍发展，这对于减少化学工业中的废物流至关重要，并且可以在劳动密集型药物多步合成中节省时间。Jones教授与蒙大拿州立大学的Cloninger教授合作进行的研究旨在培训本科研究人员进行合成、各种分析方法表征以及机械和动力学测量。