RUI: Use of Functionalized Dendrimers in Cascade Catalysis

RUI：功能化树枝状聚合物在级联催化中的应用

• 批准号: 1057690
• 负责人: Thomas Jones
• 金额: $ 12.75万
• 依托单位: College of Saint Benedict
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1057690&HistoricalAwards=false
• 关键词: RUI; Use; Functionalized; Dendrimers; Cascade

The Chemical Catalysis Program in the Chemistry Division at the National Science Foundation supports Professor Thomas Jones of the College of Saint Benedict, for the synthesis, characterization and evaluation of multifunctional dendritic cascade catalysts. The goal of this work is to attach both metal and organometallic catalysts to the perimeter of G4 poly(amido amine) dendrimers, and to make subsequent kinetic and mechanistic studies in regard to catalyst optimization. Cascade catalysts are important for the development of multi-step, one-pot reactions in organic chemistry.Broader impacts of the research are based on the general development of "atom economical" reactions, which are critical for the reduction of the waste stream in the chemical industry and can save time during labor intensive pharmaceutical multistep syntheses. The research by Professor Jones, in collaboration with Professor Cloninger at Montana State University, is geared to the training of undergraduate researchers in synthesis, characterization by a variety of analytical methods, and mechanistic and kinetic measurements.

国家科学基金会化学部的化学催化计划支持圣本尼迪克特学院的Thomas Jones教授合成、表征和评价多功能树枝状级联催化剂。这项工作的目的是将金属和有机金属催化剂固定在G4聚氨基胺树枝状大分子的周长上，并进行后续的催化剂优化的动力学和机理研究。级联催化剂对于有机化学中多步一锅反应的发展具有重要意义，其广泛的影响是建立在“原子经济”反应的总体发展基础上的，这些反应对于减少化学工业中的废气是至关重要的，并且可以在劳动密集型药物多步骤合成中节省时间。琼斯教授与蒙大拿州立大学的Cloninger教授合作进行的这项研究，旨在培训本科生研究人员在合成、用各种分析方法表征以及机械和动力学测量方面的能力。