High-field Dynamic Nuclear Polarization using Spin Probes and Intrinsic Defects at Local Interfaces of Polymers and Solids
使用自旋探针的高场动态核极化和聚合物和固体局部界面的固有缺陷
基本信息
- 批准号:1112572
- 负责人:
- 金额:$ 46.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-01 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With support from the Chemical Measurement and Imaging program in the Division of Chemistry, Prof. Song-I Han and her group at the University of California - Santa Barbara are developing new instrumentation and methodologies for high magnetic field nuclear magnetic resonance (NMR) to probe the detailed microstructure of complex and heterogeneous materials, e.g. of multiphase block copolymers or amorphous silicon. The sensitivity of conventional NMR spectroscopy is insufficient to probe the microstructural properties at the surface or interface at the necessary sub-nanometer length scale. Prof. Han addresses this challenge by developing novel dynamic nuclear polarization (DNP)-amplified NMR instrumentation and methods at 7 Tesla that enhance signals by up to five orders of magnitudes through cryogenic cooling and polarization transfer from polarized electron spins to nuclear spins. A unique and crucial aspect of the approach is utilization of strategic electron spin probes specifically located through chemical functionalization, or intrinsic paramagnetic defects that are critical to the function or malfunction of the materials. Prof. Han is adding concurrent continuous wave and pulsed electron paramagnetic resonance (EPR) detection capabilities to a home-built spectrometer to provide complete materials characterization through the nuclear and electron spin probes. The high field DNP approach may have high impact on the study of a wide range of functional and heterogeneous materials, e.g. a variety of multiphase polymer systems or amorphous and crystalline Si based photovoltaic materials, whose interfacial properties or intrinsic paramagnetic centers lie at the core of their function or malfunction. Educational impact is enhanced by provision of research opportunities for undergraduate students and by supporting professional development for women scientists pursuing high level science careers.
在加州大学圣巴巴拉分校化学系化学测量和成像项目的支持下,Song-I Han教授和她的团队正在开发新的仪器和方法,用于高磁场核磁共振(NMR),以探测复杂和非均相材料的详细微观结构,例如多相嵌段共聚物或非晶硅。常规核磁共振波谱的灵敏度不足以在必要的亚纳米尺度上探测表面或界面的微观结构性质。韩教授通过开发新的动态核极化(DNP)放大核磁共振仪器和7特斯拉的方法来解决这一挑战,通过低温冷却和从极化电子自旋到核自旋的极化转移,将信号增强多达五个数量级。该方法的一个独特而关键的方面是利用战略电子自旋探针,特别是通过化学功能化定位,或对材料的功能或故障至关重要的内在顺磁缺陷。韩教授正在为自制光谱仪增加并发连续波和脉冲电子顺磁共振(EPR)检测功能,以通过核和电子自旋探针提供完整的材料表征。高场DNP方法可能会对广泛的功能和非均相材料的研究产生重大影响,例如各种多相聚合物体系或非晶和晶体Si基光伏材料,其界面性质或本征顺磁中心是其功能或故障的核心。通过为本科生提供研究机会和支持追求高水平科学事业的女科学家的专业发展,加强了教育影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Song-I Han其他文献
Effect of PEG-based Biocompatible Polymers on the Response of Lipid Vesicles under External Stimuli
- DOI:
10.1016/j.bpj.2009.12.3428 - 发表时间:
2010-01-01 - 期刊:
- 影响因子:
- 作者:
Jia-Yu Wang;Ravinath Ravinath Kausik;Chi-Yuan Cheng;Jaemin Chin;Song-I Han;Jeremy Marks;Ka Yee C. Lee - 通讯作者:
Ka Yee C. Lee
Rapid filamentous fungi gene knockout identification through high-throughput droplet microfluidics
通过高通量液滴微流控技术快速鉴定丝状真菌基因敲除
- DOI:
10.1016/j.aca.2025.344094 - 发表时间:
2025-07-08 - 期刊:
- 影响因子:6.000
- 作者:
Yuwen Li;Jing Dai;Huan Zhang;Han Zhang;Adrian Guzman;Song-I Han;Won Bo Shim;Arum Han - 通讯作者:
Arum Han
Functional Consequences of Membrane Protein Oligomerization
- DOI:
10.1016/j.bpj.2017.11.1155 - 发表时间:
2018-02-02 - 期刊:
- 影响因子:
- 作者:
Song-I Han;Chungta Han;Matt Idso;Sunyia Hussain - 通讯作者:
Sunyia Hussain
Song-I Han的其他文献
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{{ truncateString('Song-I Han', 18)}}的其他基金
High-Field Solid-State Dynamic Nuclear Polarization with Paramagnetic Systems Beyond Simple Spin 1/2
超越简单自旋的顺磁系统高场固态动态核极化 1/2
- 批准号:
2411584 - 财政年份:2024
- 资助金额:
$ 46.5万 - 项目类别:
Standard Grant
High-Field Solid-State Dynamic Nuclear Polarization with Paramagnetic Systems Beyond Simple Spin 1/2
超越简单自旋的顺磁系统高场固态动态核极化 1/2
- 批准号:
2004217 - 财政年份:2020
- 资助金额:
$ 46.5万 - 项目类别:
Standard Grant
Probing support-solvent-solute interactions in heterogeneous catalysts by surface-sensitive magnetic resonance tools
通过表面敏感磁共振工具探测多相催化剂中载体-溶剂-溶质的相互作用
- 批准号:
1800596 - 财政年份:2018
- 资助金额:
$ 46.5万 - 项目类别:
Standard Grant
IRES: Training Next Generation Researchers in Advanced Magnetic Resonance at Chemistry Interfaces
IRES:在化学界面培训下一代高级磁共振研究人员
- 批准号:
1658652 - 财政年份:2017
- 资助金额:
$ 46.5万 - 项目类别:
Standard Grant
Dynamic nuclear polarization at 7 Tesla to enable and enhance the study of chemical structures and surfaces
7 特斯拉的动态核极化可促进和加强化学结构和表面的研究
- 批准号:
1505038 - 财政年份:2015
- 资助金额:
$ 46.5万 - 项目类别:
Continuing Grant
IDBR: Novel Electron-Nuclear Dual Resonance Instrument with Arbitrary Microwave Pulse Shaping to Advance the Structure and Dynamics Study of Biological Systems
IDBR:具有任意微波脉冲整形的新型电子核双共振仪器,可推进生物系统的结构和动力学研究
- 批准号:
1152244 - 财政年份:2012
- 资助金额:
$ 46.5万 - 项目类别:
Continuing Grant
MRI: Development of a 240 GHz Pulsed Electron Paramagnetic Resonance Spectrometer with Nanosecond Time Resolution
MRI:开发具有纳秒时间分辨率的 240 GHz 脉冲电子顺磁共振波谱仪
- 批准号:
0821589 - 财政年份:2008
- 资助金额:
$ 46.5万 - 项目类别:
Standard Grant
CAREER:Developing Novel Nuclear Magnetic Resonance Contrast and Sensitivity Enhancement Mechanisms for Materials and Reactions Studies
职业:开发用于材料和反应研究的新型核磁共振对比和灵敏度增强机制
- 批准号:
0645536 - 财政年份:2007
- 资助金额:
$ 46.5万 - 项目类别:
Continuing Grant
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High-Field Solid-State Dynamic Nuclear Polarization with Paramagnetic Systems Beyond Simple Spin 1/2
超越简单自旋的顺磁系统高场固态动态核极化 1/2
- 批准号:
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- 批准号:
2311042 - 财政年份:2023
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Dynamic Nuclear Polarization of Aerosols - A Novel Approach for Imaging Water Vapor and Enabling Lung Imaging
气溶胶的动态核极化——一种水蒸气成像和肺部成像的新方法
- 批准号:
10372747 - 财政年份:2022
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功能化硅纳米粒子的高场动态核极化 NMR - 体内成像之路
- 批准号:
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气溶胶的动态核极化——一种水蒸气成像和肺部成像的新方法
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High Field Dynamic Nuclear Polarization NMR on Functionalized Silicon Nanoparticles - A Path Toward in vivo Imaging
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548101-2020 - 财政年份:2021
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Alexander Graham Bell Canada Graduate Scholarships - Doctoral
High-Field Solid-State Dynamic Nuclear Polarization with Paramagnetic Systems Beyond Simple Spin 1/2
超越简单自旋的顺磁系统高场固态动态核极化 1/2
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2004217 - 财政年份:2020
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