New nano-sculptured thin film structures for biosensing applications

用于生物传感应用的新型纳米雕刻薄膜结构

• 批准号: 202496977
• 负责人: Professor Dr. Bernd Rauschenbach
• 金额: --
• 依托单位: Leibniz-Institut für Oberflächenmodifizierung e.V. (IOM)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/202496977?language=en
• 关键词: New; nano; sculptured; thin; film

Nanotechnological solutions for environmental and medical sensing are addressed in this trilateral proposal by the lOM Leipzig Germany, BGU Israel and Al-Quds University Palestine. There is a need for rapid sensing of pollutants in water, toxins and pathogens in blood and in other body liquids. This problem Is and shall always remain an ongoing concern worldwide. In order to effectively address the problem, a class of nanomaterials will be used called sculptured thin films (STFs) and a sensing technique to exploit surface-enhanced optical phenomena. STFs have a columnar morphology comprising nano-columns of various shapes and made of 1-3 nm clusters. Their porosity allows infiltration by a liquid as well as functionalization to target specific analytes (toxins, etc.). STFs of different materials will be designed and fabricated at the lOM, using thermal evaporation and electronbeam evaporation methods, on glass slides and silicon wafers. The slides could be nanolithographically patterned to promote the lab-on-a-chip concept. The materials for STFs Include metals or dielectrics that are coated thinly with a metal. After evaluation at the lOM of their morphology and planewave reflection/transmission spectra, STFs will be evaluated at BGU and Al-Quds as platforms to exploit surface-enhanced Raman scattering, fluorescence, surface-plasmon resonance, and local surface-plasmon resonance. Sensors based on these phenomena will then be built which will require functionalization of their surfaces as well as bioreceptor conjugation for specific target detection.

德国莱比锡 IOM、以色列 BGU 和巴勒斯坦圣城大学在这项三方提案中讨论了环境和医学传感的纳米技术解决方案。需要快速感测水中的污染物、血液和其他体液中的毒素和病原体。这个问题现在并且将永远是全世界持续关注的问题。为了有效解决这个问题，将使用一类称为雕刻薄膜（STF）的纳米材料和利用表面增强光学现象的传感技术。 STF 具有柱状形态，由各种形状的纳米柱组成，由 1-3 nm 簇组成。它们的孔隙率允许液体渗透以及针对特定分析物（毒素等）的功能化。不同材料的STF将在lOM中使用热蒸发和电子束蒸发方法在载玻片和硅片上设计和制造。这些载玻片可以采用纳米光刻图案来推广芯片实验室的概念。 STF 的材料包括金属或薄薄地涂有金属的电介质。在对 STF 的形态和平面波反射/透射光谱进行 10M 评估后，将在 BGU 和 Al-Quds 平台上对 STF 进行评估，以利用表面增强拉曼散射、荧光、表面等离子体共振和局部表面等离子体共振。然后将构建基于这些现象的传感器，这需要对其表面进行功能化以及生物受体结合以进行特定目标检测。