EAGER: A Surface Acoustic Wave Device for High-Resolution Atherosclerotic Plaque Inspection

EAGER：用于高分辨率动脉粥样硬化斑块检查的表面声波装置

• 批准号: 1135419
• 负责人: Rasim Guldiken
• 金额: $ 19.99万
• 依托单位: University of South Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1135419&HistoricalAwards=false
• 关键词: EAGER; Surface; Acoustic; Wave; Device

1135419GuldikenIn this EArly-concept Grants for Exploratory Research (EAGER) proposal, we aim to investigate a low power, biocompatible surface acoustic wave (SAW) device for detailed interrogation of plaque composition to quantify its vulnerability to rupture. This information is vital in fundamental understanding of coronary heart disease, the leading cause of mortality in developed countries. In this interdisciplinary pilot study, an interdigital transducer and sensor array platform will be explored that will make contact with the arterial wall for inspection. As the micro-device is in contact with the arterial wall, any boundary condition change (such as existence of vulnerable plaque) will alter the phase and amplitude of the received wave. This response change will be used to quantify the ?health? of the arterial wall. The proposed research in nature is "high risk-high reward" with research outcome benefiting millions of people not only in U.S., but also worldwide including medically underserved geographical areas and people at high risk for developing coronary heart disease. Also, this work may have significant impact on patient care, potentially reducing the morbidity and mortality; and may affect the U.S. economy by decreasing healthcare costs.Intellectual Merit:This interdisciplinary research program will advance the fundamental knowledge on atherosclerotic plaque characterization by fundamentally investigating a low power, biocompatible surface acoustic wave (SAW) device for detailed interrogation of plaque composition to quantify its vulnerability to rupture. If successful, this work will lead to an integrated, compact, efficient and simple SAW device that is capable of accurately identifying vulnerable plaques as well as other significant applications. The significant novel items in the proposed work are 1) first time demonstration of surface acoustic wave based atherosclerotic plaque characterization; 2) a platform addressing limitations of the current state-of-the-art costly vulnerable plaque detection systems.Broader Impact:The concepts contained in this proposal are not only applicable for vulnerable plaque detection, but also for ultra-sensitive sensor technology for wide variety of applications and in mixing applications. The proposed SAW device platform may find use in new generation of high-density devices in various fields including targeted drug delivery; medical, chemical and environmental monitoring systems; medical diagnostics applications; cooling of microelectronic devices and micro-propulsion for space applications. The proposed interdisciplinary technique may also solve wide variety of important clinical problems, for instance via establishing a low powered, fully-integrated (with mixers, sensors, valves, pumps, separators, etc.) lab-on-a-chip device for disease detection in low-resource settings.An unrestricted access research website explaining fundamentals and broad impact of acoustic based medical devices and documenting our research progress will be established in a language suitable for broad non-technical audience. The successful graduate training grant programs in USF (NSF IGERT, NSF Bridge to the Doctorate I, II, III and Alfred P. Sloan Minority PhD) will be leveraged for bright student recruitment within minorities and females. Education will focus on a graduate/undergraduate level course "Fundamental acoustic concepts and acoustic transducers" that will be developed attracting students from several departments. Information sessions and separate PI's lab tours demonstrating basic acoustic experiments during the frequent visit from local high-schools to the state of the art Nanotechnology Research and Education Center (NREC) will enable further motivation of students to pursue higher education in STEM fields. K-12 students will also be given opportunity to gain hands-on experience in the PI's lab as a part of outreach efforts.

1135419 Guldiken在这个早期概念的探索性研究赠款（EAGER）提案中，我们的目标是研究一种低功率、生物相容性表面声波（SAW）设备，用于详细询问斑块成分，以量化其破裂的脆弱性。这些信息对于从根本上了解发达国家的主要死亡原因冠心病至关重要。在这项跨学科的试点研究中，将探索叉指换能器和传感器阵列平台，该平台将与动脉壁接触进行检查。当微型装置与动脉壁接触时，任何边界条件变化（例如易损斑块的存在）将改变接收到的波的相位和振幅。这种反应变化将被用来量化？健康吗？动脉壁。自然界提出的研究是“高风险-高回报”的，研究成果不仅使美国数百万人受益，而且还包括全世界范围内，包括医疗服务不足的地理区域和患冠心病的高风险人群。此外，这项工作可能会对病人护理产生重大影响，可能会降低发病率和死亡率，并可能会影响美国经济通过降低医疗成本。智力优点：这一跨学科的研究计划将推进动脉粥样硬化斑块表征的基础知识，从根本上研究低功率，生物相容性表面声波（SAW）设备的详细询问斑块组成，以量化其破裂的脆弱性。如果成功，这项工作将导致一个集成的，紧凑的，高效的和简单的SAW设备，能够准确地识别脆弱的斑块以及其他重要的应用。在拟议的工作中的重要的新项目是1）基于表面声波的动脉粥样硬化斑块表征的第一次演示; 2）一个平台，解决了目前最先进的昂贵的易损斑块检测系统的局限性。更广泛的影响：在这个建议中包含的概念不仅适用于易损斑块检测，而且还适用于各种应用和混合应用的超灵敏传感器技术。所提出的SAW器件平台可用于各种领域的新一代高密度器件，包括靶向药物输送;医疗、化学和环境监测系统;医疗诊断应用;微电子器件的冷却和空间应用的微推进。所提出的跨学科技术还可以解决各种重要的临床问题，例如通过建立低功率、完全集成的（具有混合器、传感器、阀、泵、分离器等）用于低资源环境下疾病检测的芯片实验室设备。一个不受限制访问的研究网站，解释基于声学的医疗设备的基本原理和广泛影响，并记录我们的研究进展，将以适合广泛的非技术受众的语言建立。在USF（NSF IGERT，NSF桥博士学位I，II，III和阿尔弗雷德·P·斯隆少数民族博士）成功的研究生培训补助金计划将用于少数民族和女性中的优秀学生招聘。教育将侧重于研究生/本科水平的课程“基本声学概念和声学换能器”，将吸引来自几个部门的学生。信息会议和单独的PI的实验室图尔斯参观展示了基本的声学实验期间，从当地高中到最先进的纳米技术研究和教育中心（NREC）的频繁访问将使学生进一步的动机追求在STEM领域的高等教育。K-12学生也将有机会在PI的实验室获得实践经验，作为推广工作的一部分。