NSF/FDA SIR: In Vitro Biological Characterization of Nanoporous Diamond Membranes

NSF/FDA SIR：纳米多孔金刚石膜的体外生物学表征

• 批准号: 1136330
• 负责人: Roger Narayan
• 金额: $ 13万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-11-01 至 2014-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1136330&HistoricalAwards=false
• 关键词: NSF; FDA; SIR; Vitro; Biological

1136330NarayanThe research objective of the proposed Scholar-in-Residence program is to apply nanofabrication technologies (e.g., microwave plasma-enhanced chemical vapor deposition and atomic layer deposition) and nanostructured materials (e.g., ultrananocrystalline diamond) to solve problems associated with biofouling and size-selective transport of nanoscale biological molecules. As part of this program, graduate student participants will perform in vitro biological characterization of nanoporous diamond membranes at the FDA?s Center for Devices and Radiological Health (CDRH) laboratories.The information obtained in the biological characterization, materials characterization, and functional characterization studies will serve as the basis for a chemical property-physical property-performance database, which will guide the development of nanoporous diamond membranes and other nanoporous biomaterials. In this database, the relationship between in vitro cell-material interaction, protein adsorption, and several processing parameters, including diamond crystallinity, titanium nitride crystallinity, pore size, pore density, and surface morphology, will be considered. The planned research is well-suited to goals of the NSF/FDA Scholar-in-Residence program, because it combines an advanced processing method at the UNC/NCSU Joint Department of Biomedical Engineering with comprehensive biological characterization facilities at the Food and Drug Administration.

1136330纳拉扬拟议的奖学金驻校计划的研究目标是应用纳米纤维技术（例如，微波等离子体增强化学气相沉积和原子层沉积）和纳米结构材料（例如，超纳米晶金刚石）来解决与纳米级生物分子的生物污染和尺寸选择性输送相关的问题。作为该计划的一部分，研究生参与者将在FDA进行纳米多孔金刚石膜的体外生物表征？在生物表征、材料表征和功能表征研究中获得的信息将作为化学性质-物理性质-性能数据库的基础，该数据库将指导纳米多孔金刚石膜和其他纳米多孔生物材料的开发。在该数据库中，将考虑体外细胞-材料相互作用、蛋白质吸附和几个工艺参数（包括金刚石结晶度、氮化钛结晶度、孔径、孔密度和表面形态）之间的关系。计划中的研究非常适合NSF/FDA驻校奖学金计划的目标，因为它结合了生物医学工程部/NCSU联合部门的先进处理方法与食品和药物管理局的综合生物表征设施。