CNIC: US-Australia Planning Visits for UNC-NCSU-Queensland Partnership on Novel Materials and Devices for Transdermal Sensors

在该CNIC项目中，Tarl Prow博士（昆士兰州大学皮肤病学研究中心副主任）和PI提出了一种创新机制，用于微创和原位检测黑色素瘤进展，使用含有微针和微阵列的新型微型设备，检测黑色素瘤特异性的化学过程。三名研究生研究助理（美国公民或美国永久居民）将前往Prow博士的实验室进行为期四个月的研究，以执行以下任务：（1）用于黑色素瘤透皮检测的微针装置的合成，（2）微针皮肤表征和机械表征，以及（3）评估微针微阵列装置检测黑色素瘤功能的研究。拟议努力的目标是促进PI和Prow博士之间新的国际合作，他们是唯一有资格实现计划目标的人。Prow博士的实验室开创了基于微针的黑色素瘤检测的先河。私家侦探？他的实验室率先开展了涉及用于透皮药物输送和传感的微针快速原型设计的研究工作。该项目将有助于改善黑色素瘤的治疗，使小样本重复从单一病变随着时间的推移，从而使参与黑色素瘤的分子机制得到更好的理解。PI正在罗利为更广泛社区的年轻人举办一系列讲座和科学演示;这些"科学星期六"活动在北卡罗来纳州自然科学博物馆举行。PI和学生将在这些活动中结合项目的结果和演示材料。

In this CNIC program, Dr. Tarl Prow (Deputy Director, Dermatology Research Center, University of Queensland) and the PI propose an innovative mechanism for minimally invasive and in situ detection of melanoma progression using novel microscale devices that contain microneedles as well as microarrays, which detect chemical processes specific to melanoma. Three graduate research assistants (US citizens or US permanent residents) will travel to Dr. Prow's laboratory for four month periods to perform the following tasks: (1) synthesis of microneedle devices for transdermal detection of melanoma, (2) microneedle-skin characterization and mechanical characterization, and (3) studies to assess the functionality of microneedle-microarray devices for detection of melanoma. The goal of the proposed effort is to catalyze new international collaborations between the PI and Dr. Prow, who are uniquely qualified to achieve the program goals. Dr. Prow's lab has pioneered efforts involving microneedle-based detection of melanoma. The PI?s lab has pioneered research efforts involving rapid prototyping of microneedles for transdermal drug delivery and sensing. The project will contrbute to improved melanoma treatment by enabling small samples to be repeatedly obtained from single lesions over time, thus allowing molecular mechanisms involved in melanomagenesis to be better understood. The PI is leading a series of lectures and scientific demonstrations in Raleigh for young people in the broader community; these "Science Saturday" events take place at the North Carolina Museum of Natural Sciences. The PI and students will incorporate results and demonstration materials from the project in these events.