CNIC: US-Australia Planning Visits for UNC-NCSU-Queensland Partnership on Novel Materials and Devices for Transdermal Sensors

在这个CNIC项目中，Tarl Prow博士(昆士兰大学皮肤病研究中心副主任)和PI提出了一种创新的机制，使用包含微针和微阵列的新型微型设备来原位微创检测黑色素瘤的进展，微阵列可以检测黑色素瘤特有的化学过程。三名研究生研究助理(美国公民或美国永久居民)将前往Prow博士的实验室，为期四个月，执行以下任务：(1)合成用于经皮检测黑色素瘤的微针设备，(2)微针皮肤特征和机械特征，以及(3)评估用于检测黑色素瘤的微针微阵列设备的功能。拟议工作的目标是促进PI和Prow博士之间的新的国际合作，他们是唯一有资格实现该计划目标的人。普罗博士的实验室开创了基于微针检测黑色素瘤的先河。皮？S实验室率先开展了涉及用于经皮给药和传感的微针快速原型的研究工作。该项目将通过使小样本能够随着时间的推移从单个病变中重复获得来改进黑色素瘤的治疗，从而使人们能够更好地了解黑色素瘤发生的分子机制。国际和平协会正在罗利为更广泛的社区的年轻人领导一系列讲座和科学演示；这些“科学星期六”活动在北卡罗来纳州自然科学博物馆举行。PI和学生将在这些活动中纳入项目的结果和演示材料。

In this CNIC program, Dr. Tarl Prow (Deputy Director, Dermatology Research Center, University of Queensland) and the PI propose an innovative mechanism for minimally invasive and in situ detection of melanoma progression using novel microscale devices that contain microneedles as well as microarrays, which detect chemical processes specific to melanoma. Three graduate research assistants (US citizens or US permanent residents) will travel to Dr. Prow's laboratory for four month periods to perform the following tasks: (1) synthesis of microneedle devices for transdermal detection of melanoma, (2) microneedle-skin characterization and mechanical characterization, and (3) studies to assess the functionality of microneedle-microarray devices for detection of melanoma. The goal of the proposed effort is to catalyze new international collaborations between the PI and Dr. Prow, who are uniquely qualified to achieve the program goals. Dr. Prow's lab has pioneered efforts involving microneedle-based detection of melanoma. The PI?s lab has pioneered research efforts involving rapid prototyping of microneedles for transdermal drug delivery and sensing. The project will contrbute to improved melanoma treatment by enabling small samples to be repeatedly obtained from single lesions over time, thus allowing molecular mechanisms involved in melanomagenesis to be better understood. The PI is leading a series of lectures and scientific demonstrations in Raleigh for young people in the broader community; these "Science Saturday" events take place at the North Carolina Museum of Natural Sciences. The PI and students will incorporate results and demonstration materials from the project in these events.