GOALI: Collaboration on Novel Materials and Methods for 3D Printing of Microscale Medical Devices

GOALI：微型医疗器械 3D 打印新材料和方法的合作

• 批准号: 1437461
• 负责人: Roger Narayan
• 金额: $ 16.56万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1437461&HistoricalAwards=false
• 关键词: GOALI; Collaboration; Novel; Materials; Methods

Minimally invasive surveillance of locally recurrent rectal cancer remains a challenge for physicians and their patients. Results of this research will enable use of a multi-photon absorption process for 3D printing of microscale medical devices with appropriate chemical, biological, mechanical, and functional properties for use in the body, in particular for detecting locally recurrent rectal cancer. Research into 3D printing with naturally-occurring photosensitive materials will be conducted to determine if these materials possess better biocompatibility than existing 3D printed materials. Research into increasing the output of the multi-photon absorption-based 3D printing process will be performed to understand how modifications to the 3D printing process may enable more rapid manufacturing of microscale structures than conventional 3D printing processes. The research will make scientific contributions that will (a) enable innovation in 3D printing technologies for microscale medical device applications and (b) facilitate development of a new type of medical sensor for detecting a type of cancer that affects more than 40,000 Americans each year. This award also supports several events at a local science museum for the research team to disseminate results and examples from this research to young people and others in the community.The objective of this Grant Opportunity for Academic Liaison with Industry (GOALI) research is to use 3D printing of microscale medical devices as a case study to better understand (a) improvements to the 3D printing process and (b) use of naturally-occurring precursor materials for 3D printing. The plan for this research contains three overlapping eight month phases, which will be conducted over two years. Phase I will involve understanding the chemical and physical characteristics of materials that are processed with naturally-occurring photosensitive materials using 3D printing. Interactions between cells and the 3D printed materials will be examined to understand the biocompatibility of these materials. Phase II will involve mechanical characterization of the 3D printed materials and the 3D printed microscale sensors and will partially occur at the industrial partner's site. Phase III will involve in vitro studies with commercially-obtained tissue to examine the functionality of the 3D printed microscale sensors for rectal cancer detection and will occur at industrial partner's site. The industrial partner will provide guidance regarding 3D printing and sensor characterization. The intellectual significance of this research is that it will provide the scientific community with better understanding of (a) a novel 3D printing process for more rapid manufacturing of microscale structures and (b) novel 3D printing materials based on naturally-occurring photosensitive materials.

对医生和患者来说，局部复发直肠癌的微创监测仍然是一个挑战。这项研究的结果将使多光子吸收过程能够用于具有适当的化学、生物、机械和功能特性的微型医疗设备的3D打印，以用于人体，特别是用于检测局部复发的直肠癌。将对自然产生的光敏材料进行3D打印研究，以确定这些材料是否具有比现有3D打印材料更好的生物兼容性。将进行增加基于多光子吸收的3D打印方法的输出的研究，以了解对3D打印方法的修改如何能够比传统的3D打印方法更快地制造微型结构。这项研究将做出科学贡献，将(A)实现用于微型医疗设备应用的3D打印技术的创新，(B)促进一种新型医疗传感器的开发，以检测一种每年影响超过4万美国人的癌症。该奖项还支持在当地一家科学博物馆为研究团队举办的几项活动，向年轻人和社会其他人传播这项研究的结果和例子。这项研究的目的是将微型医疗设备的3D打印作为案例研究，以更好地了解(A)3D打印过程的改进和(B)使用自然生成的前体材料进行3D打印。这项研究的计划包括三个重叠的八个月阶段，将在两年内进行。第一阶段将涉及了解使用3D打印使用自然产生的光敏材料处理的材料的化学和物理特性。将研究细胞与3D打印材料之间的相互作用，以了解这些材料的生物兼容性。第二阶段将涉及3D打印材料和3D打印微型传感器的机械特性，部分将在工业合作伙伴的现场进行。第三阶段将涉及用商业获得的组织进行体外研究，以检验3D打印微型传感器检测直肠癌的功能，并将在工业合作伙伴的现场进行。工业合作伙伴将提供有关3D打印和传感器表征的指导。这项研究的学术意义在于，它将使科学界更好地了解(A)用于更快速地制造微尺度结构的新型3D打印工艺，以及(B)基于自然产生的光敏材料的新型3D打印材料。