NSF/FDA Scholar in Residence Program on In Vitro Biological Characterization of 3D Printed Small-Scale Medical Devices
NSF/FDA 3D 打印小型医疗器械体外生物学表征常驻学者项目
基本信息
- 批准号:1445727
- 负责人:
- 金额:$ 13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-11-01 至 2017-10-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PI: Narayan, Roger J.Proposal: 1445727Title: NSF/FDA Scholar in Residence Program on In Vitro Biological Characterization of 3D Printed Small-Scale Medical DevicesSignificanceThe data obtained in this project will serve as the basis for a material property-biological performance database, in which the relationship between in vitro cell-material interactions, protein adsorption, and material processing parameters will be considered. The regulatory science approach will provide a repertoire of methods and tools to understand the fundamental tissue-material interactions for complex and innovative device technologies.Technical DescriptionIn the proposed Scholar-in-Residence (SIR) program, a 3D printing technique known as multi-focus two photon polymerization will be used to create solid tissue barb adhesives with microscale features for tissue penetration and sub-microscale features for cell ingrowth out of a zirconium oxide hybrid material. Tissue barbs are innovative small-scale devices with potential use in wound closure and healing. They will examine use of biocompatible photoinitiators (e.g., riboflavin-triethanolamine mixtures and riboflavin-arginine mixtures) for two photon polymerization-based 3D printing. They will also evaluate incorporation of an electrochemical sensor for monitoring of creatinine within the tissue barb adhesive. In the proposed program, they will collaborate with FDA colleagues to evaluate the in vitro biocompatibility of tissue barb materials that contain sub-micrometer scale pores and creatinine sensor materials using appropriate cells (e.g., dermal fibroblasts and epidermal keratinocytes).
PI: Narayan, Roger j .提案:1445727标题:NSF/FDA驻校学者3D打印小型医疗器械体外生物学表征项目意义该项目获得的数据将作为材料特性-生物性能数据库的基础,其中将考虑体外细胞-材料相互作用,蛋白质吸附和材料加工参数之间的关系。调控科学方法将提供一系列方法和工具,以了解复杂和创新设备技术的基本组织-材料相互作用。技术描述在拟议的驻校学者(SIR)计划中,一种被称为多焦点双光子聚合的3D打印技术将用于制造固体组织钩状粘合剂,该粘合剂具有用于组织渗透的微尺度特征和用于氧化锆杂化材料向内生长的亚微尺度特征。组织倒钩是一种创新的小型装置,在伤口闭合和愈合方面具有潜在的用途。他们将研究生物相容性光引发剂(例如,核黄素-三乙醇胺混合物和核黄素-精氨酸混合物)用于基于双光子聚合的3D打印。他们还将评估用于监测组织倒钩粘合剂内肌酐的电化学传感器的结合。在拟议的项目中,他们将与FDA的同事合作,使用适当的细胞(如真皮成纤维细胞和表皮角质形成细胞)评估含有亚微米级孔和肌酐传感器材料的组织刺材料的体外生物相容性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Roger Narayan其他文献
Recent advances of boron-doped diamond electrochemical sensors toward environmental applications
- DOI:
10.1016/j.coelec.2021.100920 - 发表时间:
2022-04-01 - 期刊:
- 影响因子:6.900
- 作者:
Pratik Joshi;Parand Riley;K.Yugender Goud;Rupesh K. Mishra;Roger Narayan - 通讯作者:
Roger Narayan
Recent Developments in Electronic, Functional, and Biological Thin Films
- DOI:
10.1007/s11837-012-0303-7 - 发表时间:
2012-03-23 - 期刊:
- 影响因子:2.300
- 作者:
Roger Narayan - 通讯作者:
Roger Narayan
Laser-assisted formation of 3c-SiC and continuous diamond growth using Si–Q carbon on (100) silicon
激光辅助形成 3c-SiC 以及使用 (100) 硅上的 Si-Q 碳连续生长金刚石
- DOI:
10.1557/s43578-023-01264-7 - 发表时间:
2023 - 期刊:
- 影响因子:2.7
- 作者:
Nayna Khosla;Jagdish Narayan;Roger Narayan - 通讯作者:
Roger Narayan
Correction to: Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold
- DOI:
10.1007/s11665-021-05719-y - 发表时间:
2021-04-13 - 期刊:
- 影响因子:2.000
- 作者:
Chander Prakash;Gurminder Singh;Sunpreet Singh;Linda Yongling Wu;H. Y. Zheng;Seeram Ramakrishna;Roger Narayan - 通讯作者:
Roger Narayan
Molecular imprinted polymer based microneedle-strip electrochemical sensor for label-free dopamine monitoring: Advancing neurological disorder Diagnostics
基于分子印迹聚合物的微针条电化学传感器用于无标记多巴胺监测:推进神经障碍诊断
- DOI:
10.1016/j.cej.2025.163870 - 发表时间:
2025-07-15 - 期刊:
- 影响因子:13.200
- 作者:
Lakshmi R. Panicker;Anjalin Joy;P.R. Anusree;Sachin Kadian;Roger Narayan;A. Padmesh;Yugender Goud Kotagiri - 通讯作者:
Yugender Goud Kotagiri
Roger Narayan的其他文献
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{{ truncateString('Roger Narayan', 18)}}的其他基金
IRES Track I: US-South Korea Collaborative Training Program on Advances in Medical 3D Printing
IRES Track I:美韩医疗 3D 打印进展合作培训项目
- 批准号:
2106331 - 财政年份:2021
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
EAGER: Light Integrated novel multimodal microscale transdermal drug delivery biosystem
EAGER:光集成新型多模式微尺度透皮给药生物系统
- 批准号:
2029974 - 财政年份:2020
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
NSF/FDA Scholar in Residence Program on Physico-Chemical Characterization and In Vitro Biological Evaluation of 3D Printed Ceramics
NSF/FDA 3D 打印陶瓷物理化学表征和体外生物学评估常驻学者项目
- 批准号:
2037636 - 财政年份:2020
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
GOALI: Laser-based Layer-by-Layer Nanomanufacturing of Water Insoluble Drug-Loaded Thin Films
GOALI:基于激光的逐层纳米制造水不溶性载药薄膜
- 批准号:
1762202 - 财政年份:2018
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
Use of Diamond-Like Carbon Coatings to Reduce Leachables From Biomedical Metal Alloys and Polymeric Materials
使用类金刚石碳涂层减少生物医学金属合金和聚合物材料中的浸出物
- 批准号:
1836767 - 财政年份:2018
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
ICorps: Innovative Printing Approach for Transdermal Drug Delivery
ICorps:透皮给药的创新印刷方法
- 批准号:
1612937 - 财政年份:2016
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
EAGER: Minimally invasive biosensors for detecting flavivirus infection
EAGER:用于检测黄病毒感染的微创生物传感器
- 批准号:
1651359 - 财政年份:2016
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
CNIC: US-Australia Planning Visits for UNC-NCSU-Queensland Partnership on Novel Materials and Devices for Transdermal Sensors
CNIC:美国-澳大利亚计划访问北卡罗来纳大学-北卡罗来纳州立大学-昆士兰大学关于透皮传感器新型材料和设备的合作伙伴关系
- 批准号:
1401950 - 财政年份:2014
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
GOALI: Collaboration on Novel Materials and Methods for 3D Printing of Microscale Medical Devices
GOALI:微型医疗器械 3D 打印新材料和方法的合作
- 批准号:
1437461 - 财政年份:2014
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
NSF/FDA Scholar in Residence Program on Characterization of Micro- and Nanostructured Titanium Oxide and Zirconium Oxide Surfaces for Improved Medical Implants
NSF/FDA 常驻学者项目,研究用于改进医疗植入物的微米和纳米结构氧化钛和氧化锆表面的表征
- 批准号:
1343533 - 财政年份:2013
- 资助金额:
$ 13万 - 项目类别:
Standard Grant
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