Modeling, Identification, and Control towards Adaptive Personalized Glucose Management for Insulin-Deficient Diabetes

该奖项的研究目标是开发个性化适应性胰岛素治疗的建模和控制算法。这些算法可以用于1型糖尿病的人工胰腺，也可以用于胰岛素依赖型2型糖尿病的血糖管理。这项研究将通过带有时变参数的数据驱动模型来表征患者特定的血糖动态，这些参数可以根据自然生活条件下食物摄入量、体力活动和情绪基调的影响进行调整。这项研究还将开发自适应控制算法，使之能够更好地控制高血糖和预防低血糖。将解决关于碳水化合物含量估计的不确定性、进餐延迟的不确定性以及胰岛素和碳水化合物敏感性的变化的稳健性问题。成果包括易于实施的胰岛素-葡萄糖动力学实时参数估计算法，胰岛素输送的自适应控制算法，通过FDA批准的1型糖尿病模拟器进行评估和验证，研究结果文档，以及工程学学生教育。如果成功，这项研究的结果将通过提供一种控制算法来促进机械人造胰腺的开发，该控制算法用于关闭人工胰腺中葡萄糖传感和胰岛素输送之间的循环。1型或2型糖尿病患者将从这项研究的结果中受益，因为它降低了许多破坏性的长期并发症的风险。通过FDA批准的模拟平台进行测试和评估后，结果可以转换为用于临床测试的胰岛素泵。工科学生将通过高级设计项目以及本科生和研究生水平的控制课程项目参与到这项研究中，例如，设计用户友好的工具来帮助控制饮食和改进控制算法。

The research objective of this award is to develop modeling and control algorithms for personalized adaptive insulin therapy. The algorithms can be used in the artificial pancreas for type-1 diabetes, but also would be useful for glucose management for insulin-dependent type-2 diabetes. This research will characterize patient-specific glucose dynamics by data-driven models with time-varying parameters that can be adjusted for the effects of food intake, physical activity and emotional tone under natural living conditions. This research will also develop adaptive control algorithms that enable a better control of hyperglycemia and prevention of hypoglycemia. Robustness issues will be addressed with respect to uncertainties in estimation of carb content, uncertain time-delay of meal intake, and variations in insulin and carb sensitivities. Deliverables include easy-to-implement real-time parameter estimation algorithms for insulin-glucose kinetics, adaptive control algorithms for insulin delivery, evaluation and validation via a FDA-approved simulator for type-1 diabetes, documentation of research results, and engineering student education.If successful, the results of this research will facilitate the development of a mechanical artificial pancreas by means of providing a control algorithm used to close the loop between glucose sensing and insulin delivery in the artificial pancreas. Patients with type-1 or type-2 diabetes will benefit from the results of this research by lowering the risk of many of the devastating long-term complications. After testing and evaluation through FDA-approved simulation platforms, the results are transformable to be used in insulin pumps for clinical tests. Engineering students will get involved in this research through senior design projects as well as projects in undergraduate- and graduate-level control courses, e.g., design of user-friendly tools in aiding the control of diet and improvement of control algorithms.