Development of functional polymer-protein core-shell nanoparticles

功能性聚合物-蛋白质核-壳纳米粒子的开发

• 批准号: 1307319
• 负责人: Qian Wang
• 金额: $ 39万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1307319&HistoricalAwards=false
• 关键词: Development; functional; polymer; protein; core

In this project funded by the Macromolecular, Supramolecular, and Nanochemistry (MSN) program in the Division of Chemistry, Qian Wang of the University of South Carolina will develop a new strategy to synthesize functional polymer-protein core-shell nanoparticles. Specifically, the project will focus on the design and synthesis of biocompatible and biodegradable polymers for the fabrication of polymer-protein core-shell nanoparticles. The assembly process will be characterized quantitatively using solution small angle neutron scattering, fluorescent microscopy, isothermal titration calorimetry and quartz crystal microbalance techniques. Finally, in order to validate the synthetic chemistry, a model core-shell nanoparticle system will be created for delivery and release of a molecular payload. The broader impacts of the project involve the interdisciplinary training of project participants, ranging from high school students to undergraduate and graduate students. The project will enable them to develop advanced research skills and provide international networks that will serve students well in their future careers under the ever-growing situation of economic globalization. This research project will uncover new ways to create small particles with nanometer dimensions that are hybrids of synthetic materials and proteins. Such knowledge is essential for the development of low-cost, structurally well-defined particles that could be used for applications ranging from drug delivery, to protein pharmaceuticals, and to the stabilization and support of enzyme catalysts.

在这个由化学系大分子、超分子和纳米化学（MSN）项目资助的项目中，南卡罗来纳州大学的王倩将开发一种新的策略来合成功能性聚合物-蛋白质核壳纳米颗粒。具体而言，该项目将专注于设计和合成生物相容性和可生物降解的聚合物，用于制造聚合物-蛋白质核壳纳米颗粒。组装过程将采用溶液小角中子散射，荧光显微镜，等温滴定量热法和石英晶体微天平技术进行定量表征。最后，为了验证合成化学，将创建用于分子有效载荷的递送和释放的模型核-壳纳米颗粒系统。该项目的更广泛影响涉及对项目参与者的跨学科培训，从高中生到本科生和研究生。该项目将使他们能够发展先进的研究技能，并提供国际网络，这将有助于学生在经济全球化日益增长的情况下，在未来的职业生涯。该研究项目将揭示创造纳米尺寸小颗粒的新方法，这些颗粒是合成材料和蛋白质的混合物。 这些知识对于开发低成本、结构明确的颗粒至关重要，这些颗粒可用于从药物递送到蛋白质药物以及酶催化剂的稳定和支持的应用。