MRI: Acquisition of a MALDI Tandem Mass Spectrometer (MALDI MS) as an analytical tool to support multidisciplinary research at University of South Carolina

MRI：购买 MALDI 串联质谱仪 (MALDI MS) 作为支持南卡罗来纳大学多学科研究的分析工具

• 批准号: 2216137
• 负责人: Qian Wang
• 金额: $ 47万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216137&HistoricalAwards=false
• 关键词: MRI; Acquisition; MALDI; Tandem; Mass

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Professor Qian Wang and colleagues Linda Shimizu, Johannes Stratmann, Michael Walla, Chang Liu from the University of South Carolina - Columbia, are acquiring a matrix-assisted laser desorption / ionization time-of-flight mass spectrometer (MALDI-TOF-MS) equipped with a photodiode array. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. MALDI TOF combines gentle ionization (ideal for producing intact ions of peptides, proteins, nucleic acids, carbohydrates, synthetic polymers, and other similarly sized species) with a detection mode that offers an excellent balance between sensitivity and accuracy across a wide range of samples. The acquisition strengthens the research infrastructure at the university and within the regional. The instrument broadens participation by giving hands-on access to a diverse student population. The instrument is also used in outreach activities. The award is aimed at enhancing research and education at all levels. It especially impacts studies correlating molecular structure, orientation and dynamics. Researchers use the MALDI-TOF-MS to study analysis of bioconjugation products of proteins and protein-based nanoparticles, supramolecular assemblies, nanoreactors and conjugated polymers, imaging of intracellular algal toxins, protein & DNA characterization, electronics and photophysics of metal-organic hybrids, organic ligand analysis , analysis of boronic acid modified peptides, molecular weight analysis of functional polymers, characterization of peptides and small proteins from microbes, study of plant-pathogen interactions, biosensors and biomarkers for clinical diagnosis, cell and tissue targeted drug delivery, study the protein interactions, imaging of vascular structures and tissue scaffolds, pharmacokinetics and pharmacodynamics studies, imaging of vascular structures, imaging of vascular structures, analysis biodegradable polymers, dendrimer based biomaterials for tissue engineering applications, analysis of ligands for organometallic synthesis, analysis of insoluble organic molecules.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要的研究工具和化学研究工具计划的支持。 Qian Wang及其同事Linda Shimizu，Johannes Stratmann，Michael Walla，Chang Liu，来自南卡罗来纳大学的Chang Liu - 哥伦比亚大学，正在收购配备光谱仪（MALDI-TOF-MS）的Matrix激光解吸 /电离时间，并配备了光电量ARRAY。通常，质谱法（MS）是用于识别和表征复杂样品中少量化学物种的关键分析方法之一。 Maldi Tof结合了温和的电离（非常适合生产肽，蛋白质，核酸，碳水化合物，合成聚合物和其他类似尺寸的物种的完整离子和检测模式，该模式在广泛的样品范围内提供了良好的平衡。此次收购加强了大学和区域内的研究基础设施。该乐器通过动手访问多样化的学生群体来扩大参与。该仪器还用于外展活动。该奖项旨在增强各级研究和教育。它特别影响了将分子结构，方向和动力学相关的研究。 Researchers use the MALDI-TOF-MS to study analysis of bioconjugation products of proteins and protein-based nanoparticles, supramolecular assemblies, nanoreactors and conjugated polymers, imaging of intracellular algal toxins, protein & DNA characterization, electronics and photophysics of metal-organic hybrids, organic ligand analysis , analysis of boronic acid modified peptides, molecular weight analysis of functional polymers, characterization of peptides and small proteins from microbes, study of plant-pathogen interactions, biosensors and biomarkers for clinical diagnosis, cell and tissue targeted drug delivery, study the protein interactions, imaging of vascular structures and tissue scaffolds, pharmacokinetics and pharmacodynamics studies, imaging of vascular structures, imaging of vascular结构，分析可生物降解聚合物，基于树枝状的生物材料用于组织工程应用，分析有机金属合成的配体，分析不溶性有机分子。这奖反映了NSF的法规任务，并认为通过基金会的知识优点进行评估，并值得通过评估来进行评估。